Results 61 to 70 of about 7,170,895 (193)
Background Continuous use of amphetamines, alcohol, benzodiazepines, cannabis, cocaine, or opioids contributes to health impairments, increased morbidity, and overdose deaths among patients with substance use disorders (SUDs).
Jørn Henrik Vold +5 more
doaj +1 more source
Codeine toxicity via breast Milk: Can this occur and implications for opiate therapy in children
Codeine is commonly used in combination analgesic products. The use of codeine during breastfeeding can rarely be associated with serious adverse effects related to genetic polymorphisms affecting codeine's metabolism and disposition. Clinicians treating infants of breastfeeding mothers should be aware of this rare but potentially serious complication.
Michael Rieder
wiley +1 more source
ABSTRACT First Nations in Canada are exercising inherent sovereignty through cannabis entrepreneurship, enacting community‐based regulatory frameworks and asserting jurisdictional authority over economic activities within their territories. Through analyzing 71 Canadian media articles, this study examines how First Nations governance innovation and ...
Tamara Donnelly, Iliana Loupessis
wiley +1 more source
Methods of Assessing Postoperative Pain in Infants (0–12 Months): A Scoping Review
ABSTRACT Infants undergoing surgery experience postoperative pain beyond acute short‐lasting procedural pain and have variable analgesic needs. Assessing pain in this nonverbal population presents challenges for clinicians and parents. Given the short‐ and long‐term effects of pain and its treatment, timely and accurate assessment of pain is vital. The
Jeewan Jyoti +5 more
wiley +1 more source
Background For people with opioid dependence in Norway, chronic hepatitis C virus (HCV) infections contribute to high mortality and high morbidity. Around 50% of patients in medically assisted rehabilitation (MAR) have been shown to have HCV, and the ...
Ole Jørgen Lygren +7 more
doaj +1 more source
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga +20 more
wiley +1 more source
The global rise in opioid-related harms has impacted the United States severely. Current efforts to manage the opioid crisis have prompted a re-evaluation of many of the existing roles in the healthcare system, in order to maximize their individual ...
Paxton Bach, Daniel Hartung
doaj +1 more source
ABSTRACT Drug hypersensitivity reactions (DHRs) are a global health concern and remain challenging to investigate owing to the heterogeneity of endotypes and phenotypes, as well as the lack of standardized biomarkers. Until recently, strict drug avoidance was the only management strategy for severe DHRs.
Ana Maria Copaescu +13 more
wiley +1 more source
A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation
The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix +4 more
wiley +1 more source
Patient and public involvement is widely thought to be important in the improvement of health care delivery and in health equity.Purpose: The article examines the role of experiential knowledge in service co-production in order to develop opiate ...
Hannele Palukka +3 more
doaj +1 more source

