Results 101 to 110 of about 593,453 (414)

Chronic, Battery‐Free, Fully Implantable Multimodal Spinal Cord Stimulator for Pain Modulation in Small Animal Models

open access: yesAdvanced Science, EarlyView.
This work introduces wireless‐powered fully implantable spinal cord stimulation (SCS) in freely moving animal models, supporting diverse ethological paradigms. kHz stimulation with real‐time digital programming offers versatile, dynamically optimized therapy. Scalable fabrication ensures high N studies and seamless translation.
Allie J. Widman   +11 more
wiley   +1 more source

AAV gene therapy vectors in the TMJ

open access: yesClinical and Experimental Dental Research, Volume 8, Issue 6, Page 1561-1566, December 2022., 2022
Abstract Objectives The goal of this project was to evaluate the use of two adeno‐associated viral vector serotypes, adeno‐associated viral vectors (AAV)‐2 and AAV‐6, approved for and used for gene therapy in humans, for the delivery of therapeutic genes to the temporomandibular joint (TMJ) and the attendant sensory nerves.
Sabine M. Brouxhon   +2 more
wiley   +1 more source

Developing a comprehensive inventory to define harm reduction housing

open access: yesHarm Reduction Journal
Background The City of Boston has faced unprecedented challenges with substance use amidst changes to the illicit drug supply and increased visibility of homelessness.
Sofia Zaragoza   +9 more
doaj   +1 more source

Behavioral architecture of opioid reward and aversion in C57BL/6 substrains

open access: yesFrontiers in Behavioral Neuroscience, 2015
Drug liking versus drug disliking is a subjective motivational measure in humans that assesses the addiction liability of drugs. Variation in this trait is hypothesized to influence vulnerability versus resilience toward substance abuse disorders and ...
Stacey L Kirkpatrick, Camron D Bryant
doaj   +1 more source

Promoting Awareness of the Opioid Epidemic in Rural Vermont [PDF]

open access: yes, 2017
Vermont is in the middle of an opioid epidemic. Heroin use fatalities are on the rise and the number of people in treatment for opioid use disorder in Rutland County has tripled in recent years.
Olson, Kathleen
core   +1 more source

Opioid Abuse in Chronic Pain--Misconceptions and Mitigation Strategies.

open access: yesNew England Journal of Medicine, 2016
Chronic pain not caused by cancer is among the most prevalent and debilitating medical conditions but also among the most controversial and complex to manage.
Dan L. Longo, N. Volkow, A. Mclellan
semanticscholar   +1 more source

When Epidemics Collide: Coronavirus Disease 2019 (COVID-19) and the Opioid Crisis

open access: yesAnnals of Internal Medicine, 2020
COVID-19 could cause infection in persons with opioid use disorder, increase opioid overdose rates, reverse system-level gains in expanding access to medication for opioid use disorder, halt critical research, and prevent exacting legal reparations ...
W. Becker, D. Fiellin
semanticscholar   +1 more source

State-Level Economic Costs of Opioid Use Disorder and Fatal Opioid Overdose — United States, 2017

open access: yesMMWR. Morbidity and mortality weekly report, 2021
Approximately 47,000 persons in the United States died from an opioid-involved overdose in 2018 (1), and 2.0 million persons met the diagnostic criteria for an opioid use disorder in 2017 (2). The economic cost of the U.S.
Feijun Luo, Mengyao Li, C. Florence
semanticscholar   +1 more source

The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model

open access: yesAdvanced Science, EarlyView.
Intratracheal neomycin alters pulmonary microbiota, activating the vagus nerve via lung brain‐derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) pathway, further projecting to nucleus of solitary tract (NTS), then dorsal raphe nucleus (DRN), where activated serotoninergic neurons increase brain serotonin, alleviating migraine.
Biying Liu   +7 more
wiley   +1 more source

How the presentation of patient information and decision-support advisories influences opioid prescribing behavior: A simulation study [PDF]

open access: yes, 2020
ObjectiveThe United States faces an opioid crisis. Integrating prescription drug monitoring programs into electronic health records offers promise to improve opioid prescribing practices.
Hussain, Mustafa I   +4 more
core  

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