Results 141 to 150 of about 495,046 (363)
ChemMedChem, EarlyView.Docking and molecular dynamics simulations within CYP2E1 clarify the structural basis for the reduced hepatotoxicity of novel non‐opioid analgesics developed as safer alternatives to acetaminophen. The results reveal that hydrophobicity and substituent size critically influence binding conformations, thereby modulating toxicity.
Claire Coderch +5 more
wiley +1 more source
High molecular weight opioid-containing proteins in striatum.
, 1978 Randolph V. Lewis +4 more
openalex +1 more source
Differential ontogeny of multiple opioid receptors (mu, delta, and kappa) [PDF]
, 1985 J W Spain, BL Roth, CJ Coscia
openalex +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.CYP2D6 alleles with low frequency in Eurocentrically biased study populations are often excluded from pharmacogenetic investigation and consequently may have misassigned activity values. This health inequity may be contributing to imprecise dose predictions for CYP2D6‐metabolizing drugs.
Oyinlade Kehinde +6 more
wiley +1 more source
Provider Education & Requirements for Opioid Prescriptions [PDF]
, 2017 Nationally, there has been a surge in the opioid prescription crisis with associated overdose deaths. Vermont is no exception, with increasing opioid overdose related deaths within the last 10 years.
Leung, Lawrence J
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Oral medications encounter gut commensal microbes that participate directly and indirectly in drug effects through metabolism, interactions with drug metabolites, or production of substrates that compete with drugs for drug‐metabolizing enzymes, consequently influencing drug pharmacokinetics.
Naomi Gronich +11 more
wiley +1 more source
One Year Study of Chest X-Ray Changes in Opiate -poisoned Patients in Hamadan
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2010 Background and Objectives: Intoxication with opiates is one of the most common causes of referring to emergency departments in Iran. Because respiratory signs are one of the most common and important signs in these patients, this study was designed to ...
S Afzali, MR Jafari
doaj
Clinical Pharmacology &Therapeutics, EarlyView.Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan +6 more
wiley +1 more source
Comparison of opioid prescribing by dentists in the United States and England [PDF]
, 2019 Importance: The United States consumes most of the opioids worldwide despite representing a small portion of the world\u27s population. Dentists are one of the most frequent US prescribers of opioids despite data suggesting that nonopioid analgesics are ...
Calip, Gregory S +7 more
core +1 more source
Isolation and characterization of the opioid peptides from rat pituitary: beta-lipotropin.
, 1977 Menachem Rubinstein +3 more
openalex +1 more source