Results 231 to 240 of about 593,453 (414)

Waxy‐ or Putty‐Like Materials as a Novel Drug Preparation for Synthetic Cannabinoid Receptor Agonists: Detection in Prisons and In Vitro Cannabinoid Receptor Activity

open access: yesDrug Testing and Analysis, EarlyView.
Waxy‐ or putty‐like materials has emerged as a novel drug preparation for synthetic cannabinoids and other drugs in UK prisons. An in vitro CB1 bioassay was used to evaluate the CB1 activating potential of MDMB‐INACA and extracts from eight seized samples. MDMB‐INACA had moderate efficacy but low potency at CB1.
Axelle Timmerman   +9 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

open access: yes, 2022
Hepatology, EarlyView.
Robert J. Fontana   +6 more
wiley   +1 more source

Treatment barriers and gender‐based perceptions: Establishing gender‐based treatment specialty facilities as a strategy to motivate South African young women to seek treatment for substance use disorders

open access: yesJournal of Community Psychology, Volume 51, Issue 1, Page 182-200, January 2023., 2023
Abstract South Africa alongside other low‐middle‐income countries have been some of the hardest hit by the substance use scourge. The study sought to identify and measure treatment barriers among young adults (18–29 years) living with substance use disorders, and then examine the role of gender in the perception of treatment barriers, with a view to ...
Tichaenzana Nyashanu, Herbert Zirima
wiley   +1 more source

Associations between pain-management treatments and opioid use disorder risk among Medicaid patients [PDF]

open access: yesarXiv
Introduction: Chronic pain patients are at increased risk of opioid-misuse. Less is known about the unique risk conferred by each pain-management treatment, as treatments are typically implemented together, confounding their independent effects. We estimated the extent to which pain-management strategies were associated with risk of incident opioid use
arxiv  

Retrospective Evaluation of Novel Synthetic Opioids and Xylazine Chronic Intake by Post‐Mortem Hair Testing

open access: yesDrug Testing and Analysis, EarlyView.
The study presents a validated UPLC‐MS/MS method applied for the detection of fentanyl, NPFs, xylazine, nitazenes in hair samples from 250 post‐mortem cases collected at the Jefferson County Coroner/Medical Examiner's Office (Birmingham, AL, USA). In 52% of the analyzed hair samples, fentanyl, its main metabolites, and related analogs were detected ...
Marco Ballotari   +6 more
wiley   +1 more source

Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo‐Pyridyl Synthetic Cannabinoid Receptor Agonist CH‐FUBBMPDORA

open access: yesDrug Testing and Analysis, EarlyView.
Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer   +13 more
wiley   +1 more source

Opioid-mediated suppression of cultured peripheral blood mononuclear cell respiratory burst activity. [PDF]

open access: bronze, 1987
Phillip K. Peterson   +4 more
openalex   +1 more source

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