Results 241 to 250 of about 258,746 (296)

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

Strengths and Opportunities: Clinicians' Perspectives on Palliative Care for Amyotrophic Lateral Sclerosis (ALS) in the United States

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Little is known about the state of palliative care (PC) for people with ALS (pALS) in the U.S. We aimed to examine current practice regarding PC for pALS and how it can be improved. Methods ALS and PC clinicians completed surveys about: (1) strengths and limitations of PC for pALS provided by ALS and PC teams, (2) reasons for
Kara E. Bischoff, Gayle Kojimoto, David L. O'Riordan, Yaowaree L. Leavell, Samuel Maiser, Astrid Grouls, Alexander K. Smith, Steven Z. Pantilat, Benzi M. Kluger, Ambereen K. Mehta   +9 more
wiley   +1 more source

Quality indicators for opioid stewardship interventions in hospital inpatient and emergency departments: a systematic review. [PDF]

Pain Rep
Dutkiewicz C, Jauregui K, Liu S, Dabliz R, Patanwala AE, Penm J.   +5 more
europepmc   +1 more source

Pain Experiences and Prescription Pain Medications Among People With Selected Muscular Dystrophies in the Muscular Dystrophy Surveillance, Tracking, and Research Network

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Pain is a recognized symptom of muscular dystrophy (MD), but little is known about prescription pain medications in this population. We describe pain experiences and pain medications prescribed for individuals with selected MDs using population‐based surveillance data collected by the Muscular Dystrophy Surveillance, Tracking,
Jonathan Suhl, Kristin M. Conway, Shiny Thomas, Sonja A. Rasmussen, James F. Howard, Nicholas E. Johnson, Paul A. Romitti, Katherine D. Mathews, The Muscular Dystrophy Surveillance, Tracking and Research Network (MD STARnet)   +9 more
wiley   +1 more source

Steroids for Pediatric Adenotonsillectomy Pain—A Prospective Multicenter Randomized Trial

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To compare postoperative caregiver‐reported pain control of two steroid regimens following pediatric adenotonsillectomy. Secondary objectives assessed differences in analgesic use, return to normal diet, caregiver calls, adverse effects, and emergency room (ER) visits. Study Design Prospective randomized pragmatic trial.
Kevin D. Pereira, Wiktoria A. Gocal, Anna V. Borodianski, Mary E. Williamson, Hengameh K. Behzadpour, Sonal Saraiya, Diego A. Preciado, Amal Isaiah   +7 more
wiley   +1 more source

Presence and Location of CatSper 1-4, Opioid (μ, δ and κ) and CD44 Receptors in SPERMATOZOA from AOUDAD, IBERIAN IBEX and Mouflon. [PDF]

Vet Med Sci
Vicente-Carrillo A, Álvarez-Rodríguez M, Castaño C, Toledano-Díaz A, Martínez-Nevado E, Rodríguez-Martínez H, Santiago-Moreno J.   +6 more
europepmc   +1 more source

Who Gets Referred to School‐Based Trauma Treatment? A Descriptive Analysis of Bounce Back and Support for Students Exposed to Trauma

Psychology in the Schools, EarlyView.
ABSTRACT This study describes one district's experience having counselors deliver, for the first time, a school‐based treatment to address student trauma symptoms. After their initial training, school counselors rated Bounce Back (K‐5th grade) and Support for Students Exposed to Trauma (5th−12th grade) as highly acceptable and anticipated a positive ...
Yourdanos Bekele, Kristin Scardamalia, Sharon A. Hoover, Cindy M. Schaeffer   +3 more
wiley   +1 more source

Implementation interventions to promote healthcare professional uptake of evidence-based opioid deprescribing for adults with chronic non-cancer pain. [PDF]

Cochrane Database Syst Rev
Langford AV, Wallis JA, Reeve E, Buchbinder R, Cross AJ, Turner J, Docking S, Haas R, Johnston RV, Ackerman IN, Cyril S, Wale J, Gnjidic D, Gorelik A, O'Connor D.   +14 more
europepmc   +1 more source

Low‐value interventions to deimplement: A secondary analysis of a systematic review of low back pain clinical practice guidelines

PM&R, EarlyView.
Abstract Objective To perform a secondary review of low back pain (LBP) clinical practice guidelines (CPG) identified in a recently conducted systematic review and to synthesize and summarize low‐value recommendations as practices that may be candidates for deimplementation.
Daniel Tai, Eunyeop Kim, Prateek Grover, Alejandro Rodriguez, Timothy J. Olivier, Thiru M. Annaswamy   +5 more
wiley   +1 more source

Molecular and cellular basis of mu-opioid receptor signaling: mechanisms underlying tolerance and dependence development. [PDF]

Front Neurosci
Swingler M, Donadoni M, Unterwald EM, Maggirwar SB, Sariyer IK.   +4 more
europepmc   +1 more source