Results 91 to 100 of about 87,811 (348)

ATHENA: A Phase 3, Open-Label Study Of The Safety And Effectiveness Of Oliceridine (TRV130), A G-Protein Selective Agonist At The µ-Opioid Receptor, In Patients With Moderate To Severe Acute Pain Requiring Parenteral Opioid Therapy. [PDF]

, 2019
Background:Pain management with conventional opioids can be challenging due to dose-limiting adverse events (AEs), some of which may be related to the simultaneous activation of β-arrestin (a signaling pathway associated with opioid-related AEs) and G ...
Beard, Timothy L, Bergese, Sergio D, Berkowitz, Richard D, Brzezinski, Marek, Cochrane, Kristina, Habib, Ashraf S, Hammer, Gregory B, Mace, Sharon E, Minkowitz, Harold S, Pan, Peter H, Wase, Linda   +10 more
core  

Variations in Human Trigeminal and Facial Nerve Branches and Foramina Identified by Dissection and Microcomputed Tomography

Clinical Anatomy, EarlyView.
ABSTRACT The aim of this study was to identify branches of the trigeminal and facial nerves (FNs) relevant to surgical incisions and injections and the scalp block techniques in the frontotemporal region, and to determine their relationships with superficial vascular structures and bony landmarks.
Hannah L. Grimes, Valentina Pizzuti, Maria A. Wright, Kane P. J. Colston, Thomas Santarius, Susan Jones   +5 more
wiley   +1 more source

Treating Homeless Opioid Dependent Patients with Buprenorphine in an Office-Based Setting [PDF]

, 2007
CONTEXT Although office-based opioid treatment with buprenorphine (OBOT-B) has been successfully implemented in primary care settings in the US, its use has not been reported in homeless patients.
Alford, Daniel P., Cheng, Debbie M., Hohl, Carole A., LaBelle, Colleen T., O'Connell, James J., Richardson, Jessica M., Samet, Jeffrey H.   +6 more
core   +3 more sources

Antinociceptive and Anti‐inflammatory Effect of Nicandrin B Isolated From Datura ferox in Zebrafish

Chemistry &Biodiversity, EarlyView.
ABSTRACT Nicandrin B (Nic B), a withanolide isolated from Datura ferox leaves, was investigated for its antinociceptive and anti‐inflammatory effects in adult zebrafish (Danio rerio). Animals treated with Nic B (4, 20, and 40 mg/kg) showed no toxicity and maintained normal locomotor activity.
Jéssica Bezerra Maciel, Hortência Ribeiro Liberato, Antônio Wlisses da Silva, Maria Auxiliadora Solange Silva Gondim Pereira, Emanuela de Lima Rebouças, Francisco das Chagas L. Pinto, Matheus Nunes da Rocha, Maria Kueirislene Amâncio Ferreira, Janaina Serra Azul Monteiro Evangelista, Izabel Florindo Guedes, Marcia Machado Marinho, Emmanuel Silva Marinho, Andreia Ferreira de Castro Gomes, Otília Loiola Pessoa, Jane Eire Silva Alencar de Menezes, Hélcio Silva dos Santos   +15 more
wiley   +1 more source

Multimodal Pain Management in Older Elective Arthroplasty Patients

Geriatric Orthopaedic Surgery & Rehabilitation, 2017
Background: Pain management after elective arthroplasty in older adults is complicated due to the risk of undertreatment of postoperative pain and potential adverse effects from analgesics, notably opioids.
Elaine Brooks MN, Susan H. Freter MD, Susan K. Bowles PharmD, MSc, David Amirault MD   +3 more
doaj   +1 more source

Managing Prolonged Pain After Surgery: Examining the Role of Opioids. [PDF]

, 2018
A notable minority of patients experience persistent postsurgical pain and some of these patients consequently have prolonged exposure to opioids. Risk factors for prolonged opioid use after surgery include preoperative opioid use, anxiety, substance ...
Pozek, John-Paul J., Schwenk, Eric S., Viscusi, Eugene R.   +2 more
core   +1 more source

Update on medication-overuse headache and its treatment [PDF]

, 2015
OPINION STATEMENT: Medication-overuse headache-i.e., a too-frequent consumption of acute headache medications leading to increased headache frequency and reduced effectiveness of acute and preventive treatments-is a serious medical condition whose ...
Giamberardino MA, MARTELLETTI, Paolo, Mitsikostas DD   +2 more
core   +1 more source

Carum carvi and Ormenis multicaulis Extracts: Chemical Analysis and In Vivo Experiments to Evaluate the Synergistic Analgesic and Anti‐Inflammatory Effects

Chemistry &Biodiversity, EarlyView.
ABSTRACT The purpose of the present investigation was to determine the effects of combination of Ormenis multicaulis dry flower methanolic extracts and Carum carvi seed methanolic extracts on pain and inflammation, compared to their use separately. High‐performance liquid chromatography (HPLC) analysis of methanolic extracts showed the presence of ...
El Mahdi Wakrim, Karima Raoui, Hamid Kabdy, Jawad Laadraoui, Mehdi Ait Laaradia, Chafik Terrafe, Sami Mnif, Brahim Bouizgarne, Stefania Garzoli, Abderrahman Chait   +9 more
wiley   +1 more source

Novel Insights Into the Bioactive Profile and Therapeutic Potentials of Indonesian Annona muricata Leaves

Chemistry &Biodiversity, EarlyView.
Pharmacological investigation of the aqueous extract of Annona muricata L. leaves from Indonesia. ABSTRACT This study investigates, for the first time, the comprehensive pharmacological profile of the aqueous extract of Annona muricata L. (graviola) leaves from Indonesia, focusing on its antioxidant, antinociceptive, and anti‐inflammatory properties ...
Sara Oufquir, Fatimazahra Agouram, Hamid Kabdy, Mehdi Ait Laaradia, Khadija Oubella, Baslam Abdelmoniim, Aboufatima Rachida, Stefania Garzoli, Abderrahman Chait   +8 more
wiley   +1 more source

Classification of pain and its treatment at an intensive care rehabilitation clinic [PDF]

, 2016
Introduction Treatment in an Intensive Care Unit (ICU) often necessitates uncomfortable and painful procedures for patients throughout their admission.
Daniel, M., Devine, H., Kinsella, J., MacTavish, P., McPeake, J., Quasim, T.   +5 more
core   +1 more source