Extended-Release and Long-Acting Opioid Analgesics Risk Evaluation and Mitigation Strategy (REMS):
, 2017 In response to the proliferation and abuse of opioids in the United States, the U.S. Food and Drug Administration (FDA) recently required manufacturers of extended-release and long-acting (ER/LA) opioid analgesics to provide education for prescribers of ...
D. U. Rabin +3 more
semanticscholar +1 more source
Ultrasound-Guided Lateral Femoral Cutaneous Nerve Cryoneurolysis for Analgesia in Patients With Burns. [PDF]
, 2020 Autologous skin grafting from the thigh is frequently required for treatment of burns and is associated with intense pain at the donor site. Local anesthetic-based (LA) nerve blocks of the lateral femoral cutaneous nerve (LFCN) have been demonstrated to ...
Fiallo, Alfredo +6 more
core
Cohort Study of the Impact of High-Dose Opioid Analgesics on Overdose Mortality [PDF]
, 2016 OBJECTIVE: Previous studies examining opioid dose and overdose risk provide limited granularity by milligram strength and instead rely on thresholds. We quantify dose-dependent overdose mortality over a large spectrum of clinically common doses.
Dasgupta, Nabarun +5 more
core +2 more sources
Pain medicine (Malden, Mass.), 2017 Objective. Opioid abuse is a serious public health concern. In response, the Food and Drug Administration (FDA) determined that a risk evaluation and mitigation strategy (REMS) for extended-release and long-acting (ER/LA) opioids was necessary to ensure ...
M. Cepeda +5 more
semanticscholar +1 more source
Discovering heterogeneous subpopulations for fine-grained analysis of opioid use and opioid use disorders [PDF]
arXiv, 2018 The opioid epidemic in the United States claims over 40,000 lives per year, and it is estimated that well over two million Americans have an opioid use disorder. Over-prescription and misuse of prescription opioids play an important role in the epidemic.
arxiv
Multimodal Pain Management in Older Elective Arthroplasty Patients
Geriatric Orthopaedic Surgery & Rehabilitation, 2017 Background: Pain management after elective arthroplasty in older adults is complicated due to the risk of undertreatment of postoperative pain and potential adverse effects from analgesics, notably opioids.
Elaine Brooks MN +3 more
doaj +1 more source
A Knowledge Graph-based Approach for Exploring the U.S. Opioid Epidemic [PDF]
arXiv, 2019 The United States is in the midst of an opioid epidemic with recent estimates indicating that more than 130 people die every day due to drug overdose. The over-prescription and addiction to opioid painkillers, heroin, and synthetic opioids, has led to a public health crisis and created a huge social and economic burden.
arxiv
Identifying Spatiotemporal Patterns in Opioid Vulnerability: Investigating the Links Between Disability, Prescription Opioids and Opioid-Related Mortality [PDF]
BMC Public Health 25, 1759 (2025)The opioid crisis remains one of the most daunting and complex public health problems in the United States. This study investigates the national epidemic by analyzing vulnerability profiles of three key factors: opioid-related mortality rates, opioid prescription dispensing rates, and disability rank ordered rates. This study utilizes county level data,
arxiv +1 more source
Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics
Journal of Neuroscience, 2015 Treating pain is one of the most difficult challenges in medicine and a key facet of disease management. The isolation of morphine by Friedrich Sertürner in 1804 added an essential pharmacological tool in the treatment of pain and spawned the discovery ...
Tuan Trang +5 more
semanticscholar +1 more source
ATHENA: A Phase 3, Open-Label Study Of The Safety And Effectiveness Of Oliceridine (TRV130), A G-Protein Selective Agonist At The µ-Opioid Receptor, In Patients With Moderate To Severe Acute Pain Requiring Parenteral Opioid Therapy. [PDF]
, 2019 Background:Pain management with conventional opioids can be challenging due to dose-limiting adverse events (AEs), some of which may be related to the simultaneous activation of β-arrestin (a signaling pathway associated with opioid-related AEs) and G ...
Beard, Timothy L +10 more
core