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Structure-based discovery of opioid analgesics with reduced side effects
Nature, 2016 Aashish Manglik +2 more
exaly +2 more sources
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Refractory dependence on opioid analgesics
Pain, 2019In the present article, we argue that individuals with chronic pain on chronic opioids can develop a complex refractory dependence syndrome which we define here as Opioid Dependence. We further argue that Opioid Dependence is equivalent to the withdrawal/
Jane C. Ballantyne +2 more
openaire +4 more sources
BMJ, The, 2015 Objective To study the association between benzodiazepine prescribing patterns including dose, type, and dosing schedule and the risk of death from drug overdose among US veterans receiving opioid analgesics. Design Case-cohort study.
Tae Woo Park +2 more
exaly +2 more sources
Geographic Variation in the Prescription of Schedule II Opioid Analgesics among Outpatients in the United States [PDF]
Health Services Research, 2006 Lesley H Curtis, Raymond L Woosley
exaly +2 more sources
Opioid and non-opioid analgesics
Best Practice & Research Clinical Anaesthesiology, 2003Opioids are the most potent analgesics. Toxicity results either from effects mediated by variation in affinity and intrinsic efficacy at specific opioid receptors or, rarely, from a direct toxic effect of the drugs. For some adverse effects, opioids exhibit a 'dual pharmacology' whereby these effects are usually observed only in pain-free individuals ...
Gail Gillespie +2 more
openaire +3 more sources
Veterinary Clinics of North America: Small Animal Practice, 2000
Opioids are useful and potent drugs for the management of pain in small animal patients. They have a wide therapeutic index and can be given by a number of different routes. Some of these techniques (e.g., epidural and intraarticular) allow for the production of profound analgesia in a localized area of the body while limiting the dose and the side ...
openaire +2 more sources
Opioids are useful and potent drugs for the management of pain in small animal patients. They have a wide therapeutic index and can be given by a number of different routes. Some of these techniques (e.g., epidural and intraarticular) allow for the production of profound analgesia in a localized area of the body while limiting the dose and the side ...
openaire +2 more sources
Anaesthesia & Intensive Care Medicine, 2011
Abstract When it was first discovered in the 1500s, opium was heralded as the most potent analgesic. The Latin name for morphine tincture, laudanum (to praise), illustrates the high regard in which it was held. The many adverse effects associated with its use (now attributed to non-specific opioid receptor cross-activation between subtypes ...
David G. Lambert +3 more
openaire +2 more sources
Abstract When it was first discovered in the 1500s, opium was heralded as the most potent analgesic. The Latin name for morphine tincture, laudanum (to praise), illustrates the high regard in which it was held. The many adverse effects associated with its use (now attributed to non-specific opioid receptor cross-activation between subtypes ...
David G. Lambert +3 more
openaire +2 more sources
Perspectives on cannabis as a substitute for opioid analgesics.
Pain Management, 2019With the opioid epidemic reaching new heights in the USA, it has become critical to find suitable alternatives to opioids. Cannabis, an antinociceptive, is a strong contender to help patients reduce their opioid usage.
Sara P Khan +2 more
semanticscholar +1 more source