Results 91 to 100 of about 52,343 (271)

Managing Drug–Drug Interactions Involving the Non‐Prescription Opioid Loperamide Through Physiologically Based Pharmacokinetic Modeling

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Loperamide is a widely used nonprescription peripherally acting opioid indicated for diarrhea. Loperamide undergoes extensive first‐pass metabolism, primarily by cytochrome (CYP) 3A and CYP2C8, with minor contributions from CYP2B6 and CYP2D6, and intestinal efflux by P‐glycoprotein (P‐gp).
Zhu Zhou   +6 more
wiley   +1 more source

Perspectives on addiction‐related problems in Vietnam

open access: yesAddiction, Volume 121, Issue 2, Page 448-457, February 2026.
Abstract The article provides an overview of key substance use and addictive behaviors in Vietnam, alongside the development of addiction science, drawing from a synthesis of literature and the authors' perspectives. Over the last two decades, the primary illicit drug of concern has shifted from heroin to methamphetamine and other psychoactive ...
Nguyen Thu Trang   +4 more
wiley   +1 more source

Dynamic Changes in the Distribution of Hydrocodone and Oxycodone in Florida from 2006 to 2021

open access: yesPharmacy
Background: Florida, which led the country in terms of its number of opioid-prescribing physicians, was unique during the height of the opioid epidemic because of its lax prescribing laws and high number of unregulated pain clinics.
Elena Lynn Stains   +5 more
doaj   +1 more source

Opioid Update, June 13, 2018 [PDF]

open access: yes, 2018
The Iowa Department of Public Health (IDPH) offers the Opioid Update to share information about opioid use and Iowa’s efforts to address the national opioid ...

core  

Opioid Update, July 12, 2017 [PDF]

open access: yes, 2017
The Iowa Department of Public Health (IDPH) offers the Opioid Update to share information about opioid use and Iowa’s efforts to address the national opioid ...

core  

Mandatory Minimum Sentencing Policies and Cocaine Use in the U.S., 1985–2013 [PDF]

open access: yes, 2018
Background: As of May 2017, the United States federal government renewed its prioritization for the enforcement of mandatory minimum sentences for illicit drug offenses.
Mezuk, Briana, Walker, Lauryn Saxe
core   +2 more sources

Troriluzole attenuates opioid intake, reinforcing efficacy, seeking behaviours, physical dependence and antinociceptive tolerance in rats

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 3, Page 505-519, February 2026.
Background and Purpose Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake.
Ewa Galaj   +7 more
wiley   +1 more source

Opioid Update, May 16, 2018 [PDF]

open access: yes, 2018
The Iowa Department of Public Health (IDPH) offers the Opioid Update to share information about opioid use and Iowa’s efforts to address the national opioid ...

core  

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