Results 21 to 30 of about 156,077 (286)
Exploring the role of mu opioid receptor (OPRM1) and CYP2B6 gene variations for methadone pharmacogenomics. Can these variations be used to advance toxicological interpretation post-mortem?. [PDF]
Methadone is increasingly involved in drug overdose cases and the molecular actions of the drug in vivo are largely unknown requiring elucidation. This study set out to examine the relationship between methadone toxicity and CYP2B6 and mu (μ) opioid ...
Bunten, Hannah
core +9 more sources
Opioid overdose decedent characteristics during COVID-19
Annals of Medicine, 2022 Introduction Alongside the emergence of COVID-19 in the United States, several reports highlighted increasing rates of opioid overdose from preliminary data.
Gian-Gabriel P. Garcia +6 more
doaj +1 more source
Management of Opioid Analgesic Overdose [PDF]
New England Journal of Medicine, 2012 The rate of opioid analgesic overdose is proportional to the number of opioid prescriptions and the dose prescribed. This review considers the epidemiology, mechanisms, and management of opioid analgesic overdose.
Edoardo, Picetti +2 more
openaire +7 more sources
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Harm Reduction Journal, 2023 Introduction Lives lost in North America due to the unregulated drug poisoning emergency are preventable and those who survive an opioid overdose may suffer long-term disability. Rates of opioid overdose more than doubled following the onset of the COVID-
Max Ferguson +8 more
doaj +1 more source
BMJ Open, 2022 Objectives To describe the association between population size, population growth and opioid overdose deaths—overall and by type of opioid—in US commuting zones (CZs) in three periods between 2005 and 2017.Settings 741 CZs covering the entirety of the US
Ana V Diez Roux +5 more
doaj +1 more source
Addictive Behaviors Reports, 2020 Background: Opioid-overdose deaths and opioid prescriptions have increased substantially within the past decade, leading to examinations of urban-rural differences for these opioid-related outcomes, and whether annual trends differ by urban-rural status.
Jamey J. Lister +2 more
doaj +1 more source
Opioid Overdose With Parkinsonian Features [PDF]
Clinical Practice and Cases in Emergency Medicine, 2019 A 54-year-old man presented to the emergency department with confusion and Parkinsonian features after suspected heroin snorting. He had magnetic resonance imaging of the brain demonstrating isolated symmetric bilateral globus pallidus (GP) restricted diffusion and edema consistent with hypoxic ischemic encephalopathy.
Cohen, Paul, Hack, Jason B.
openaire +5 more sources
PLoS ONE, 2022 Chronic pain increases risk for opioid overdose among individuals with opioid use disorder. The purpose of this study is to evaluate the relationship between recent overdose and whether or not chronic pain is active.
Sarah M. Hartz +8 more
doaj +2 more sources
New England Journal of Medicine, 2019 Prevention of Opioid Overdose This review explains harm-reduction strategies for three groups of patients: those who have not received previous opioid therapy, those receiving long-term opioid ther...
Kavita M. Babu +2 more
openaire +4 more sources