Results 71 to 80 of about 156,077 (286)

Synthetic opioids have disrupted conventional wisdom for treating opioid overdose

Drug and Alcohol Dependence Reports
More than 90 % of opioid overdose deaths in North America are now caused by synthetic opioids, and while they are not as prevalent in the European illicit drug market, there are indications that they may become so in the near future.
Phil Skolnick, Jordan Paavola, Christian Heidbreder   +2 more
doaj   +1 more source

Preventing opioid overdoses in Europe:a critical assessment of known risk factors and preventative measures [PDF]

, 2012
This report is the outcome of a project into opioid overdoses. The remit was to focus on finding practical methods of overdose prevention. In order to fulfil this remit, a critical review of existing knowledge on overdose prevention was conducted.
Frisher, Martin, Crome, Ilana, Baldacchino, Alexander Mario, Bloor, Roger, Baldacchino, Alex   +4 more
core  

Psychiatry and the Opioid Overdose Crisis

Focus, 2019
For the third year in a row, the Centers for Disease Control and Prevention reported an unprecedented decline in life expectancy for the United States, a decline attributable mainly to drug overdose deaths and suicides. Drug overdoses have continued to rise and are now estimated to account for 70,237 deaths in 2017. The root causes of the modern opioid
Bertha K, Madras, Hilary, Connery
openaire   +3 more sources

The Link Between Opioid Misuse and Suicidal Ideation Is Strongest Among Sexual Minorities

Journal of Clinical Psychology, EarlyView.
ABSTRACT Opioid misuse and suicidal ideation (SI) are significant public health concerns in the United States, and incidence rates may be elevated among sexual minority people. We used data from the 2021 National Survey on Drug and Health (heterosexual, n = 39,647, lesbian/gay n = 1329, bisexual n = 3774) to investigate rates of opioid misuse and ...
Katherine Musacchio Schafer, Rachel M. Schott, Julia C. Dodd, Jameson K. Hirsch   +3 more
wiley   +1 more source

Addressing in‐hospital substance use: A bioethical evaluation of two possible approaches

Journal of Hospital Medicine, EarlyView.
Abstract Up to 40% of patients with substance use disorder report using non‐prescribed drugs when hospitalized. In‐hospital substance (IHSU) use is associated with poor outcomes and raises safety concerns for healthcare providers. Despite its prevalence, little guidance exists regarding best practices in responding to IHSU.
John C. Messinger, Taylor Baisey, Johanna Sluser, Benjamin A. Barsky, Marlene Martin, Leslie W. Suen   +5 more
wiley   +1 more source

Collateral Damage: Neurological Correlates of Non-Fatal Overdose in the Era of Fentanyl-Xylazine

Neuroscience Insights
Non-fatal opioid overdoses are associated with significant morbidity. Hypoxic brain injury caused by opioid-induced respiratory depression is a key mechanism of such morbidity. For example, reports describe an amnestic syndrome in opioid users associated
Dustin R Todaro, Nora D Volkow, Daniel D Langleben, Zhenhao Shi, Corinde E Wiers   +4 more
doaj   +1 more source

A Case of Opioid Overdose? Or Is It? [PDF]

The Journal of Applied Laboratory Medicine, 2018
A 28-year-old man was found unresponsive at home by a roommate. When emergency medical services (EMS) arrived, he was found to have miosis and was cyanotic with respiratory depression. He was unresponsive to intranasal naloxone (2 mg) that was administered via mucosal atomizer twice.
Deborah, French, Roy R, Gerona
openaire   +2 more sources

Spotlight commentary: Addressing the persistent problem of benzodiazepine overuse, time for clinical, educational and AI‐driven reform

British Journal of Clinical Pharmacology, EarlyView.
Jakša Vukojević, Luka Horvat, Vito Papić, Andrija Štajduhar   +3 more
wiley   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

The Dark Pyramid: Unpacking the Multidimensional Nature of the Dark Side of Leadership

British Journal of Management, EarlyView.
Abstract The dark side of leadership has been employed as an umbrella term to cover an array of concepts typically concerned with the dysfunctionality and/or toxicity of individual leaders. As the field of leadership studies moves towards ‘post‐heroic’ perspectives, we apply the same ontological positioning, adopting a ‘post‐villainous’ perspective in ...
Peter Stephenson, Richard Bolden, Morgen Witzel   +2 more
wiley   +1 more source