Results 51 to 60 of about 38,713 (298)

Codeine toxicity via breast Milk: Can this occur and implications for opiate therapy in children

British Journal of Clinical Pharmacology, EarlyView.
Codeine is commonly used in combination analgesic products. The use of codeine during breastfeeding can rarely be associated with serious adverse effects related to genetic polymorphisms affecting codeine's metabolism and disposition. Clinicians treating infants of breastfeeding mothers should be aware of this rare but potentially serious complication.
Michael Rieder
wiley   +1 more source

Effectiveness of direct patient outreach with a narrative naloxone and overdose prevention video to patients prescribed long-term opioid therapy in the USA: the Naloxone Navigator randomised clinical trial

BMJ Public Health
Introduction Public health efforts to reduce opioid overdose fatalities include educating people at risk and expanding access to naloxone, a medication that reverses opioid-induced respiratory depression.
Jason M Glanz, Ingrid A Binswanger, Shane R Mueller, Komal J Narwaney, Nicole M Wagner, Stanley Xu, Courtney R Kraus, Kris Wain, Sheila Botts   +8 more
doaj   +1 more source

Protocol for treatment of opioid overdose

, 2021
Purpose: The purpose of the project is to implement an evidence-base protocol for the management of an opioid overdose. Then, improve the staff’s confidence in recognizing patients with opioid overdose. Therefore, decreasing the opioid overdose mortality.

core   +1 more source

Rapid opioid overdose response system technologies [PDF]

, 2023
Purpose of review   Opioid overdose events are a time sensitive medical emergency, which is often reversible with naloxone administration if detected in time. Many countries are facing rising opioid overdose deaths and have been implementing rapid opioid
Alexander Baldacchino, Baldacchino, Alexander Mario, Joseph Tay Wee Teck, Tay Wee Teck, Joseph, Oteo Perez, Alberto, Alberto Oteo   +5 more
core   +1 more source

Segmental Hair Analysis of Diphenhydramine and Cyclizine Following a Single Dose

Drug Testing and Analysis, EarlyView.
A single oral dose of diphenhydramine and cyclizine can be quantified in human head hair for a minimum of 5 months and, in certain cases, for up to 1 year following intake. Among 12 study participants, the measured concentrations ranged from 0 to 610 pg/mg within 1 year post‐intake.
Jan Bílek, Marie Katrine Klose Nielsen, Robert Kronstrand, Sys Stybe Johansen   +3 more
wiley   +1 more source

3570 The Regulatory Landscape of Products to Treat Opioid Overdose

Journal of Clinical and Translational Science, 2019
OBJECTIVES/SPECIFIC AIMS: Since 1971, Naloxone has been the only FDA approved opioid antagonist indicated for use after opioid overdose. New formulations of Naloxone have been introduced into the market, including an injectable, auto-injector, and nasal ...
Pooja Singh, Kaylene Okada, Amelia Spinrad, Nancy Pire-Smerkanich, Eunjoo Pacifici   +4 more
doaj   +1 more source

The Rural Opioid Initiative Consortium description: providing evidence to Understand the Fourth Wave of the Opioid Crisis

, 2022
OBJECTIVE: To characterize and address the opioid crisis disproportionately impacting rural U.S. regions. METHODS: The Rural Opioid Initiative (ROI) is a two-phase project to collect and harmonize quantitative and qualitative data and develop tailored ...
Stopka, Thomas J., Friedmann, Peter D., Feinberg, Judith, Westergaard, Ryan P., Tsui, Judith I., Cooper, Hannah L. F., Fredericksen, Rob, Rudolph|, Abby E. Rudolph, Joseph A. C. Delaney, Pho, Mai T., Thomas J. Stopka, Allen, Todd M., P. Todd Korthuis, Todd M. Allen, Hannah L. F. Cooper, Vivian F. Go, Seal, David W., Young, April M., Smith, Gordon S., Wiley D. Jenkins, Gordon S. Smith, Korthuis, P. T., null null, David W. Seal, Crane, Heidi M., Jenkins, Richard A., Miller, William C., Ryan P. Westergaard, Delaney, Joseph A. C., Jenkins, Wiley D., William A. Zule, Judith I. Tsui, Mai T. Pho, Rob Fredericksen, Judith Feinberg, Heidi M. Crane, Rudolph, Abby E., Nance, Robin M., Richard A. Jenkins, Robin M. Nance, Whitney, Bridget M., William C. Miller, Go, Vivian F., Bridget M. Whitney, April M. Young, Peter D. Friedmann, Rudolph, Abby, Korthuis, P. Todd, Zule, William A.   +49 more
core   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

A conceptual model for understanding post-release opioid-related overdose risk

Addiction Science & Clinical Practice, 2019
Post-release opioid-related overdose mortality is the leading cause of death among people released from jails or prisons (PRJP). Informed by the proximate determinants framework, this paper presents the Post-Release Opioid-Related Overdose Risk Model. It
Paul J. Joudrey, Maria R. Khan, Emily A. Wang, Joy D. Scheidell, E. Jennifer Edelman, D. Keith McInnes, Aaron D. Fox   +6 more
doaj   +1 more source

“I don’t go to funerals anymore”: how people who use opioids grieve drug-related death in the US overdose epidemic

Harm Reduction Journal, 2022
Background Opioid-related overdose death is a public health epidemic in much of the USA, yet little is known about how people who use opioids (PWUO) experience overdose deaths in their social networks.
Allison V. Schlosser, Lee D. Hoffer
doaj   +1 more source