Results 51 to 60 of about 63,125 (287)

Association of Household Opioid Availability With Opioid Overdose

JAMA Network Open, 2023
ImportancePrevious studies that examined the role of household opioid prescriptions in opioid overdose risk were limited to commercial claims, did not include fatal overdoses, and had limited inclusion of household prescription characteristics. Broader research is needed to expand understanding of the risk of overdose.ObjectiveTo assess the role of ...
Hendricks, Michelle A., El Ibrahimi, Sanae, Ritter, Grant A., Flores, Diana, Fischer, Michael A., Weiss, Roger D., Wright, Dagan A., Weiner, Scott G.   +7 more
openaire   +2 more sources

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

British Journal of Clinical Pharmacology, EarlyView.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins, Alan Wells, Nimish Patel, Nicole Muttera, Mattia Trunfio, Alessandra Manca, Amedeo De Nicolò, Micol Ferrara, Stefano Bonora, Jessica Cusato, Alice Palermiti, Antonio D'Avolio, Marissa Borochoff, Patricia K. Riggs, Elizabeth Hastie, Rabia S. Atayee, Stephanie Solso, Cheryl Dullano, Vanessa Gomez‐Moreno, Tara Tenenbaum, Robert Deiss, Davey M. Smith, Antoine Chaillon, Sara Gianella   +23 more
wiley   +1 more source

Assessing knowledge, attitudes, and barriers to opioid overdose among college students

BMC Public Health
Background College students are a key population for opioid use, misuse, and subsequent exposure to overdose events. However, their knowledge and attitudes in response to opioid overdose warrant further study. To assess this gap, we surveyed graduate and
Abass Babatunde, Amanda N. Stover, Brian Witrick, Moonseong Heo, Lior Rennert   +4 more
doaj   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Effectiveness of direct patient outreach with a narrative naloxone and overdose prevention video to patients prescribed long-term opioid therapy in the USA: the Naloxone Navigator randomised clinical trial

BMJ Public Health
Introduction Public health efforts to reduce opioid overdose fatalities include educating people at risk and expanding access to naloxone, a medication that reverses opioid-induced respiratory depression.
Jason M Glanz, Ingrid A Binswanger, Shane R Mueller, Komal J Narwaney, Nicole M Wagner, Stanley Xu, Courtney R Kraus, Kris Wain, Sheila Botts   +8 more
doaj   +1 more source

R.I. State Police Unveil Innovative Opioid Outreach Initiative at RWU [PDF]

, 2018
With 323 overdose deaths in 2017, Rhode Island is at the epicenter of the opioid ...
Public Affairs, Roger Williams University
core   +1 more source

Opioid Overdose After Surgical Discharge [PDF]

JAMA, 2018
This pharmacoepidemiology study uses commercial claims database data to describe the rate of opioid overdose 1 to 3 months after surgical discharge by dose and procedure from 2004 to 2015.
Karim S, Ladha, Joshua J, Gagne, Elisabetta, Patorno, Krista F, Huybrechts, James P, Rathmell, Shirley V, Wang, Brian T, Bateman   +6 more
openaire   +2 more sources

Increasing the reporting of adverse drug reaction‐related hospitalizations using an ICD‐10‐based identification workflow: A multicentre study from Switzerland

British Journal of Clinical Pharmacology, EarlyView.
Background Reporting adverse drug reactions (ADRs) is essential for drug safety. In Switzerland, healthcare professionals are legally required to report serious and unlabelled ADRs, yet under‐reporting remains widespread. We tested a novel method to increase reporting of ADR‐related hospitalizations.
Georgia Anita Weber, Sophie‐Charlotte Bartel, Michael Boch, Christoph Rosen, Michael Bodmer, Balthasar Luzius Hug, Thomas Stammschulte, Patrick E. Beeler   +7 more
wiley   +1 more source

3570 The Regulatory Landscape of Products to Treat Opioid Overdose

Journal of Clinical and Translational Science, 2019
OBJECTIVES/SPECIFIC AIMS: Since 1971, Naloxone has been the only FDA approved opioid antagonist indicated for use after opioid overdose. New formulations of Naloxone have been introduced into the market, including an injectable, auto-injector, and nasal ...
Pooja Singh, Kaylene Okada, Amelia Spinrad, Nancy Pire-Smerkanich, Eunjoo Pacifici   +4 more
doaj   +1 more source

Differential expression of NPAS4 in the dorsolateral prefrontal cortex following opioid overdose

Drug and Alcohol Dependence Reports, 2022
Background: Although preclinical models reveal the neurobiological pathways altered through opioid abuse, comprehensive assessments of gene expression in human brain samples are needed.
David W. Sosnowski, Andrew E. Jaffe, Ran Tao, Amy Deep-Soboslay, Chang Shu, Sarven Sabunciyan, Joel E. Kleinman, Thomas M. Hyde, Brion S. Maher   +8 more
doaj   +1 more source