Results 61 to 70 of about 156,077 (286)

Differential expression of NPAS4 in the dorsolateral prefrontal cortex following opioid overdose

Drug and Alcohol Dependence Reports, 2022
Background: Although preclinical models reveal the neurobiological pathways altered through opioid abuse, comprehensive assessments of gene expression in human brain samples are needed.
David W. Sosnowski, Andrew E. Jaffe, Ran Tao, Amy Deep-Soboslay, Chang Shu, Sarven Sabunciyan, Joel E. Kleinman, Thomas M. Hyde, Brion S. Maher   +8 more
doaj   +1 more source

Law as Barrier and Facilitator to Opioid Overdose Prevention

, 2013
Prescription drug overdose is now the leading cause of accidental death. In his Critical Opportunities presentation, Corey Davis, JD, staff attorney at the Network for Public Health Law, suggests that easier access to opioid overdose reversal drugs like ...
Davis, Corey S.
core   +1 more source

Alcohol consumption in heroin users, methadone-substituted and codeine-substituted patients - Frequency and correlates of use [PDF]

, 2003
This retrospective study aims to determine whether there is a difference in the additional consumption of alcohol between addicts treated with methadone or dihydrocodeine (DHC) and untreated addicts injecting heroin.
Schütz, Christian G., Backmund, Markus, Soyka, Michael, Eichenlaub, Dieter, Meyer, Kirsten   +4 more
core   +1 more source

Advances in New Approach Methodologies at FDA's Division of Applied Regulatory Science

Clinical Pharmacology &Therapeutics, EarlyView.
New Approach Methodologies (NAMs) represent a paradigm shift in drug development and regulatory science, offering human‐relevant alternatives to traditional preclinical models. This mini‐review highlights recent advances in NAM development, validation, and regulatory application from FDA's Division of Applied Regulatory Science (DARS).
Ksenia Blinova, Kimberly Chiu, Anik Chaturbedi, Jahan Cooper, Tromondae K. Feaster, Paula L. Hyland, Lidiya Stavitskaya, Wendy W. Wu, Jeffry Florian, Rodney Rouse   +9 more
wiley   +1 more source

Opioid overdose and naloxone administration knowledge and perceived competency in a probability sample of Indiana urban communities with large Black populations.

PLoS ONE
BackgroundOpioid overdose deaths pose a serious public health concern in the United States, with disproportionately higher rates of increase among Black Americans despite expanded naloxone access.
Shin Hyung Lee, Jon Agley, Vatsla Sharma, Francesca Williamson, Pengyue Zhang, Dong-Chul Seo   +5 more
doaj   +1 more source

Unemployment and opioid overdose death patterns in the United States from 2017 to 2019

Interdisciplinary Journal of Epidemiology and Public Health
Introduction: Unemployment has been linked to increased opioid-related harms such as opioid overdose deaths. Identifying hotspots and coldspots across the United States (US) can be crucial to understanding health resources and leveraging strategies ...
Rana Khafagy, Saranya Naraentheraraja, Aranee Sathiyamoorthy   +2 more
doaj   +1 more source

A conceptual model for understanding post-release opioid-related overdose risk

Addiction Science & Clinical Practice, 2019
Post-release opioid-related overdose mortality is the leading cause of death among people released from jails or prisons (PRJP). Informed by the proximate determinants framework, this paper presents the Post-Release Opioid-Related Overdose Risk Model. It
Paul J. Joudrey, Maria R. Khan, Emily A. Wang, Joy D. Scheidell, E. Jennifer Edelman, D. Keith McInnes, Aaron D. Fox   +6 more
doaj   +1 more source

“I don’t go to funerals anymore”: how people who use opioids grieve drug-related death in the US overdose epidemic

Harm Reduction Journal, 2022
Background Opioid-related overdose death is a public health epidemic in much of the USA, yet little is known about how people who use opioids (PWUO) experience overdose deaths in their social networks.
Allison V. Schlosser, Lee D. Hoffer
doaj   +1 more source

Detection of Nitazenes in the Illicit Drug Supply Utilizing Precursor Ion Scan Methods With Paper Spray Mass Spectrometry

Drug Testing and Analysis, EarlyView.
Nitazenes are increasingly present in the illicit drug supply, complicating harm reduction efforts. We have developed a rapid, nontargeted precursor ion scan method to detect emerging nitazenes in real‐world opioid samples. The method identified multiple nitazenes, often replacing pharmaceutical opioids or mixed with fentanyl and benzodiazepines ...
Allie Miskulin, Irene Shkolnikov, Jindar Sboto, Collin Kielty, Bruce Wallace, Chris G. Gill, Dennis K. Hore   +6 more
wiley   +1 more source

Monitoring Injected Drug Use in Greece Through Syringe Residue Analysis: A Multicity Study Within the ESCAPE Network

Drug Testing and Analysis, EarlyView.
A total of 2121 used syringes were analyzed in Athens, Thessaloniki, and Patras between 2022 and 2024. Distinct drug‐use patterns were observed across the three cities. Benzodiazepines, pregabalin, methadone, and fentanyl were increasingly detected in 2024.
Christina Matiaki, Anastasios Trakakis, Athanasios Theocharis, Chara Parpala, Chara Kotsailidou, Alexandros Psarianos, Emmanouil Chatzichristofis, Eleni Zagelidu, Panagiota Roussou, Nikolaos Raikos, Orthodoxia Mastrogianni   +10 more
wiley   +1 more source