Results 131 to 140 of about 1,142,563 (307)

Imaging Nociceptin Opioid Peptide Receptors in Alcohol Use Disorder With [11C]NOP-1A and Positron Emission Tomography: Findings From a Second Cohort. [PDF]

open access: yesBiol Psychiatry, 2023
Tollefson S   +6 more
europepmc   +1 more source

Use of liquid platelet‐rich fibrin (liquid PRF) in temporomandibular joint disorders: A narrative review with clinical recommendations

open access: yesPeriodontology 2000, EarlyView.
Abstract Aim This narrative review aimed to gather evidence from comparative and non‐comparative clinical studies to assess: (1) whether the administration of liquid platelet‐rich fibrin (liquid PRF) provides any clinical benefits for managing temporomandibular disorders (TMD), and if so, based on comparative clinical studies, (2) whether it offers ...
Nima Farshidfar   +6 more
wiley   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

open access: yesExperimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela   +4 more
wiley   +1 more source

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

open access: yesMedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu   +6 more
wiley   +1 more source

Insights into the interaction between hemorphins and δ-opioid receptor from molecular modeling

open access: yesFrontiers in Molecular Biosciences
Hemorphins are short atypical opioid peptide fragments embedded in the β-chain of hemoglobin. They have received considerable attention recently due to their interaction with opioid receptors.
Priya Antony   +4 more
doaj   +1 more source

Stabilization versus flexibility: Detergent‐dependent trade‐offs in neurotensin receptor 1 GPCR ensembles

open access: yesProtein Science, Volume 35, Issue 2, February 2026.
Abstract Detergents provide essential membrane‐mimetic environments for studying G protein‐coupled receptors (GPCRs), but their molecular impact on receptor energetics remains incompletely understood. We combined ligand binding, thermostability measurements, and atomistic molecular dynamics to dissect detergent‐ versus ligand‐driven stabilization in a ...
James B. Bower   +6 more
wiley   +1 more source

Troriluzole attenuates opioid intake, reinforcing efficacy, seeking behaviours, physical dependence and antinociceptive tolerance in rats

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 3, Page 505-519, February 2026.
Background and Purpose Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake.
Ewa Galaj   +7 more
wiley   +1 more source

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