Results 141 to 150 of about 1,112,203 (348)

Threonine 180 Is Required for G-protein-coupled Receptor Kinase 3- and β-Arrestin 2-mediated Desensitization of the µ-Opioid Receptor in Xenopus Oocytes [PDF]

open access: yes, 2001
To determine the sites in the µ-opioid receptor (MOR) critical for agonist-dependent desensitization, we constructed and coexpressed MORs lacking potential phosphorylation sites along with G-protein activated inwardly rectifying potassium channels ...
Celvert, Jeremy P.   +4 more
core  

Reduction of opioid and barbiturate use following initiation of rimegepant for migraine in the United States

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective The primary objective of this study was to evaluate opioid and barbiturate utilization before and after the first prescription of the calcitonin gene–related peptide receptor antagonist rimegepant in individuals with migraine. Background Although not recommended in migraine treatment guidelines, opioids and barbiturates are often ...
Noah Rosen   +6 more
wiley   +1 more source

Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? – a systematic review

open access: yesJournal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 516-546, April 2025.
Proliferation of the term “emotion dysregulation” in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired ...
Joseph C. Blader   +2 more
wiley   +1 more source

Evaluation of in silico approach for prediction of presence of opioid peptides in wheat

open access: yesJournal of Functional Foods, 2018
Opioid like morphine and codeine are used for the management of pain, but are associated with serious side-effects limiting their use. Wheat gluten proteins were assessed for the presence of opioid peptides on the basis of tyrosine and proline within ...
Swati Garg   +3 more
doaj  

Insights into the interaction between hemorphins and δ-opioid receptor from molecular modeling

open access: yesFrontiers in Molecular Biosciences
Hemorphins are short atypical opioid peptide fragments embedded in the β-chain of hemoglobin. They have received considerable attention recently due to their interaction with opioid receptors.
Priya Antony   +4 more
doaj   +1 more source

Neuroendocrine mechanisms responsible for elevated gonadotrophin‐releasing hormone and luteinising hormone pulses in polycystic ovary syndrome

open access: yesJournal of Neuroendocrinology, EarlyView.
Abstract Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility in premenopausal individuals with ovaries worldwide. Despite the diagnostic features of anovulation, ovarian cysts, and hyperandrogenemia, which indicate that ovary dysfunction is the cause of the syndrome, changes in central neuroendocrine circuits are a ...
Aleisha M. Moore
wiley   +1 more source

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