Results 171 to 180 of about 1,142,563 (307)

Nociceptin/orphanin FQ neurons in the Arcuate Nucleus and Ventral Tegmental Area Act via Nociceptin Opioid Peptide Receptor Signaling to Inhibit Proopiomelanocortin and A₁₀ Dopamine Neurons and Thereby Modulate Ingestion of Palatable Food. [PDF]

Physiol Behav, 2021
Hernandez J, Perez L, Soto R, Le N, Gastelum C, Wagner EJ.   +5 more
europepmc   +1 more source

Dynorphin-(1-13), an extraordinarily potent opioid peptide.

Proceedings of the National Academy of Sciences of the United States of America, 1979
A. Goldstein, S. Tachibana, L. I. Lowney, M. Hunkapiller, L. Hood   +4 more
semanticscholar   +1 more source

From Synaptic Plasticity and Critical Periods to Social Behavior and Stress: Getting to, and Staying in, CA2

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT Hippocampal Area CA2, with some exceptions, had long been neglected in in vivo studies, due largely to its small size, and in in vitro studies because of its general similarity to CA3 and CA1. Increasing evidence showing that CA2 was molecularly distinct led to the increased appreciation of CA2 as a separate region, and as such, that it likely
Serena M. Dudek
wiley   +1 more source

Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release

, 2023
Zhou X, Stine C, Prada PO, Fusca D, Assoumou K, Dernic J, Bhat MA, Achanta AS, Johnson JC, Pasqualini AL, Jadhav S, Bauder CA, Steuernagel L, Ravotto L, Benke D, Weber B, Suko A, Palmiter RD, Stoeber M, Kloppenburg P, Brüning JC, Bruchas MR, Patriarchi T.   +22 more
europepmc   +1 more source

Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists. [PDF]

, 1992
Peter W. Schiller, Tin Nguyen, Grazyna Weltrowska, Brian C. Wilkes, Brian J. Marsden, C. Lemieux, Nga N. Chung   +6 more
openalex   +1 more source

Spirocyclic Diamine Scaffolds for Medicinal Chemistry

Helvetica Chimica Acta, Volume 109, Issue 1, January 2026.
Here we enumerated 391 spirocyclic diamine drug scaffolds with ring sizes four to eight and found that most of them are unknown. We prepared four novel such spirocycles and discovered a micromolar inhibitor of the M4 muscarinic receptor. ABSTRACT Medicinal chemistry requires the exploration of structurally diverse compound families to expand the ...
Aline Carrel, Alejandro Flores, Maedeh Darsaraee, Jean‐Louis Reymond   +3 more
wiley   +1 more source

MoS₂-enabled dual-mode optoelectronic biosensor using a water soluble variant of μ-opioid receptor for opioid peptide detection. [PDF]

2d Mater, 2020
De-Eknamkul C, Zhang X, Zhao MQ, Huang W, Liu R, Johnson ATC, Cubukcu E.   +6 more
europepmc   +1 more source

G Protein‐Coupled Receptor Kinase 5 (GRK5) Modulates Nociceptin/Orphanin FQ Opioid (NOP) Receptor Desensitization in Rat Sympathetic Neurons

Journal of Neuroscience Research, Volume 104, Issue 1, January 2026.
ABSTRACT Stimulation of nociceptin/orphanin FQ peptide (NOP) opioid receptors by the endogenous ligand nociceptin (Noc) leads to voltage‐gated Ca2+ channel inhibition or G protein inwardly rectifying K+ channel activation. One mechanism of G protein‐coupled receptor (GPCR) desensitization occurs when G protein‐coupled receptor kinases (GRK ...
Mohamed Farrag, Marwa Soliman, Saifeldin Mahmoud, Lauren Miller, Paul B. Herold, Kristen Brandt, Victor Ruiz‐Velasco   +6 more
wiley   +1 more source

Hormone delivery: Regulation of receptor selectivity of opioid peptides based on distribution and orientation to lipid membrane.

, 1990
Yukio Imanishi, Shunsaku Kimura
openalex   +2 more sources

Lifestyle and Behavioural Intervention Therapy for Enhanced Hippocampal Neuroplasticity

Lifestyle Medicine, Volume 7, Issue 1, January 2026.
ABSTRACT Background The neurogenic and neuroplastic capability of the brain plays a crucial role in mitigating responses to internal and external environmental stimuli. However, this process is inhibited in obesity, neurodegenerative and psychological disorders, the prevalence of which has increased on a global scale.
Ebrahim Samodien, Sylvester Ifeanyi Omoruyi, Brendon Pearce, Melisse Erasmus, Nireshni Chellan   +4 more
wiley   +1 more source