Results 181 to 190 of about 1,142,563 (307)

Associations Between Fatty Acid Levels in Human Blood and Trigeminovascular Tissues

Lipids, Volume 61, Issue 1, Page 55-63, January 2026.
ABSTRACT Omega‐3 and omega‐6 polyunsaturated fatty acids (PUFAs) are precursors to oxylipins that modulate pain and inflammation. We previously demonstrated that (1) a dietary intervention increasing omega‐3 and reducing omega‐6 PUFAs alters the concentration of these oxylipin precursors in blood, and (2) these changes are associated with reduced ...
Daisy Zamora, Mark S. Horowitz, Sharon F. Majchrzak‐Hong, Katherine Ness Shipley, Nicholas M. Salem, Ann I. Scher, Matthew R. Sapio, Michael J. Iadarola, Christopher E. Ramsden   +8 more
wiley   +1 more source

Design, Synthesis, and Characterization of Novel, Subtype-Selective Fluorescent Antagonists Targeting the Nociceptin/Orphanin FQ Opioid Peptide Receptor. [PDF]

J Med Chem
Farmer GJ, Sanchez J, Millns A, Antony T, Canals M, Lane JR, Mistry SN.   +6 more
europepmc   +1 more source

Role of nociceptin/orphanin FQ and nociceptin opioid peptide receptor in depression and antidepressant effects of nociceptin opioid peptide receptor antagonists. [PDF]

Korean J Physiol Pharmacol, 2019
Park JY, Chae S, Kim CS, Kim YJ, Yi HJ, Han E, Joo Y, Hong S, Yun JW, Kim H, Shin KH.   +10 more
europepmc   +1 more source

Cebranopadol: A Novel Potent Analgesic Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist

Journal of Pharmacology and Experimental Therapeutics, 2014
K. Linz, T. Christoph, T. Tzschentke, T. Koch, K. Schiene, M. Gautrois, W. Schröder, B. Kögel, H. Beier, W. Englberger, S. Schunk, J. de Vry, U. Jahnel, S. Frosch   +13 more
semanticscholar   +1 more source

Conceptual Density Functional Theory Study of the Chemical Reactivity Properties and Bioactivity Scores of the Leu-Enkephalin Opioid Peptide Neurotransmitter

, 2019
Juan Frau, Norma Flores‐Holguín, Daniel Glossman‐Mitnik   +2 more
openalex   +2 more sources

The choroid plexus water density

Magnetic Resonance in Medicine, Volume 95, Issue 1, Page 545-554, January 2026.
Abstract Purpose To quantify normative ranges and circadian variability of the choroid plexus (ChP) water density in healthy adults. Methods Actigraphy assessments of circadian activity were performed for 5 days in healthy participants (n = 15; age = 28.5 ± 6.5 years) and subsequently participants underwent repeated, high spatial resolution proton ...
Abigail R. Dubois, Maeve Curtin, Kilian Hett, Melanie Leguizamon, Alexander K. Song, Maria Garza, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue   +8 more
wiley   +1 more source

Conformational Plasticity Enhances the Brain Penetration of a Metabolically Stable, Dual-Functional Opioid-Peptide CycloAnt. [PDF]

Int J Mol Sci
Li Y, Cotham WE, Eliasof A, Bland K, Walla M, Pellechia PJ, Chen C, Fan D, McLaughlin JP, Liu-Chen LY.   +9 more
europepmc   +1 more source

Delta opioid peptide [d-Ala2, d-Leu5] enkephalin confers neuroprotection by activating delta opioid receptor-AMPK-autophagy axis against global ischemia. [PDF]

Cell Biosci, 2020
Lai Z, Gu L, Yu L, Chen H, Yu Z, Zhang C, Xu X, Zhang M, Zhang M, Ma M, Zhao Z, Zhang J.   +11 more
europepmc   +1 more source

A Review of Nanoparticle‐Based Astrocyte Modulation in CNS Disorders: Evaluating the Underexplored Potential of Intranasal Delivery

Nano Select, Volume 7, Issue 1, January 2026.
Nanoparticle‐driven nose‐to‐brain drug delivery offers a noninvasive approach to bypass the blood–brain barrier (BBB) and directly modulate reactive astrocytes in CNS disorders. This review highlights biodegradable nanoparticles for astrocyte modulation, enhancing drug bioavailability, sustained release, and neuroinflammation control.
Senamile M. Dlamini, Gillian D. Mahumane, Pradeep Kumar, Yahya E. Choonara   +3 more
wiley   +1 more source

Elucidation on the In Vivo Activity of the Bivalent Opioid Peptide MACE2 against Several Types of Chronic Pain. [PDF]

ACS Omega
Stefanucci A, Marinaccio L, Pieretti S, Mancuso JA, Stine C, Streicher JM, Mollica A.   +6 more
europepmc   +1 more source