European Journal of Clinical Investigation, Volume 55, Issue 10, October 2025.This review outlines the potential role of anti‐GPCR autoantibodies in MASLD/MASH, given their involvement in a wide range of diseases and their possible contribution to MASLD/MASH pathophysiology. We also focused on anti‐ApoA1 autoantibodies, sharing functional features with anti‐GPCR autoantibodies and have been shown to promote liver steatosis in ...
Sabrina Pagano +3 more
wiley +1 more source
Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors. [PDF]
J Enzyme Inhib Med Chem, 2017 Mollica A +20 more
europepmc +1 more source
Tonic inhibitory control exerted by opioid peptides in the paraventricular nuclei of the hypothalamus on regional hemodynamic activity in rats [PDF]
, 2002 Andrée Lessard, Hélène Bachelard
openalex +1 more source
Pain Perception and Modulation: Fundamental Neurobiology and Recent Advances
European Journal of Neuroscience, Volume 62, Issue 8, October 2025.Chronic pain is a major burden with variable treatment responses reflecting complex biopsychosocial and neurobiological factors. This narrative review synthesizes evidence on neural structures, circuits, and mediators involved in pain perception and modulation.
Willem W. J. van Strien +1 more
wiley +1 more source
Association Between Migraine and Periodontitis: A Systematic Review and Meta‐Analysis
European Journal of Neurology, Volume 32, Issue 10, October 2025.People exposed to migraine are 1.8 times more likely to develop periodontitis. This fact highlights the role of oral diseases that have an inflammatory component in the patient's general health affecting quality of life. Preventing periodontitis in the initial stages could contribute to the reduction of local and systemic inflammation.
Gabriel Bernat Camps‐Plomer +3 more
wiley +1 more source
Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain [PDF]
, 2003 Victor J. Hruby +7 more
openalex +1 more source
Journal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.ABSTRACT While RTP4 is known to regulate odorant receptor trafficking, its role in colorectal cancer (CRC) remains unclear. This study investigates the clinical relevance and functional mechanisms of RTP4 in CRC. Comprehensive analyses revealed significant downregulation of RTP4 expression in CRC tissues, correlating with poor patient prognosis.
Chengpeng Yu +7 more
wiley +1 more source
Astrocytes as Active Participants in Memory
Journal of Neurochemistry, Volume 169, Issue 10, October 2025.This review explores how astrocytes support memory by modulating neurotransmitters, interacting with biomolecules, and taking part in synaptic plasticity. We discuss their role across various brain regions and spotlight cutting‐edge methods—such as Ca2+ imaging, optogenetics, chemogenetics, and engram analysis—that have revolutionized our ability to ...
Shay Meron Asher, Inbal Goshen
wiley +1 more source
Orphanin FQ/nociceptin: an endogenous peptide agonist for the orphan opioid receptor
, 1998 David G. Lambert, David K. Grandy
openalex +1 more source
Colloquium C10: Opioid Peptides: Normal & Pathologic Signaling Mechanisms in Neurons & Glia [PDF]
, 2003 openalex +1 more source