Results 11 to 20 of about 21,347 (246)
Influence of opioid peptides on human neutrophil apoptosis and activation in vitro [PDF]
Mediators of Inflammation, 2002 Background: It has been shown that cells of the immune system release opioid peptides and possess receptors for them. The concentrations of opioid peptides in the peripheral circulation rapidly increase during inflammation and acute stress response.
Zofia Sulowska +4 more
doaj +2 more sources
Endogenous Opioid Peptides and Alternatively Spliced Mu Opioid Receptor Seven Transmembrane Carboxyl-Terminal Variants. [PDF]
Int J Mol Sci, 2021 There exist three main types of endogenous opioid peptides, enkephalins, dynorphins and β-endorphin, all of which are derived from their precursors. These endogenous opioid peptides act through opioid receptors, including mu opioid receptor (MOR), delta ...
Abrimian A, Kraft T, Pan YX.
europepmc +2 more sources
Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions. [PDF]
Mol Pharmacol, 2020 In the mid-1970s, an intense race to identify endogenous substances that activated the same receptors as opiates resulted in the identification of the first endogenous opioid peptides.
Fricker LD +3 more
europepmc +3 more sources
Frontiers in Pharmacology, 2023 Kappa opioid receptors have exceptional potential as an analgesic target, seemingly devoid of many problematic Mu receptor side-effects. Kappa-selective, small molecule pharmaceutical agents have been developed, but centrally mediated side-effects limit ...
Rink-Jan Lohman +4 more
doaj +1 more source
Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals
Frontiers in Neuroscience, 2022 Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Yoshihisa Uenoyama +4 more
doaj +1 more source
Biomolecules, 2020 Opioid peptides and receptors are broadly expressed throughout peripheral and central nervous systems and have been the subject of intense long-term investigations.
Ewa Gibula-Tarlowska +1 more
doaj +1 more source
Dairy, 2022 The drug-likeness and pharmacokinetic properties of 23 dairy-protein-derived opioid peptides were studied using SwissADME and ADMETlab in silico tools. All the opioid peptides had poor drug-like properties based on violations of Lipinski’s rule-of-five ...
Dawei Ji +6 more
doaj +1 more source
Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils. [PDF]
PLoS Pathogens, 2009 In inflammation, pain is regulated by a balance of pro- and analgesic mediators. Analgesic mediators include opioid peptides which are secreted by neutrophils at the site of inflammation, leading to activation of opioid receptors on peripheral sensory ...
Heike L Rittner +9 more
doaj +1 more source
Involvement of the Opioid Peptide Family in Cancer Progression
Biomedicines, 2023 Peptides mediate cancer progression favoring the mitogenesis, migration, and invasion of tumor cells, promoting metastasis and anti-apoptotic mechanisms, and facilitating angiogenesis/lymphangiogenesis.
Manuel Lisardo Sánchez +2 more
doaj +1 more source
Peptidomimetics and Their Applications for Opioid Peptide Drug Discovery
Biomolecules, 2022 Despite various advantages, opioid peptides have been limited in their therapeutic uses due to the main drawbacks in metabolic stability, blood-brain barrier permeability, and bioavailability.
Yeon Sun Lee
doaj +1 more source