Role of Milk-Derived Opioid Peptides and Proline Dipeptidyl Peptidase-4 in Autism Spectrum Disorders. [PDF]
Nutrients, 2019 Opioid peptides released during digestion of dietary proteins such as casein, were suggested to contribute to autism development, leading to the announcement of opioid excess hypothesis of autism.
Jarmołowska B +7 more
europepmc +2 more sources
Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain [PDF]
Scientific Reports, 2016 Neuropathic pain often results from peripheral nerve damage, which can involve immune response. Local leukocyte-derived opioid peptides or exogenous opioid agonists inhibit neuropathy-induced mechanical hypersensitivity in animal models.
Celik, Melih O. +3 more
core +2 more sources
Effects of Central Administration of Opioid Peptides, Vasotocin, Mesotocin, and Corticotrophin-Releasing Factor on Water Intake in Chicks [PDF]
The Journal of Poultry ScienceFreedom from thirst is an undeniable requirement of the poultry industry. However, the regulatory mechanisms underlying water intake in chicks are not yet fully understood.
Yuhui Zhang +4 more
doaj +2 more sources
Regulation of Opioid Receptors by Their Endogenous Opioid Peptides. [PDF]
Cell Mol Neurobiol, 2021 Gupta A +8 more
europepmc +2 more sources
Structures of the entire human opioid receptor family.
Cell, 2023 Opioids are effective analgesics, but their use is beset by serious side effects, including addiction and respiratory depression, which contribute to the ongoing opioid crisis.
Yue Wang +11 more
semanticscholar +3 more sources
Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides. [PDF]
J Neuroinflammation, 2016 During the inflammation which occurs following nerve damage, macrophages are recruited to the site of injury. Phenotypic diversity is a hallmark of the macrophage lineage and includes pro-inflammatory M1 and anti-inflammatory M2 populations.
Pannell M +6 more
europepmc +2 more sources
Peptidomics and pharmacological profiling of Odontobuthus doriae (Buthidae) scorpion venom at the kappa opioid receptor [PDF]
Scientific ReportsScorpion venoms are rich in bioactive peptides, many of which act on ion channels and neurotransmitter systems, yet their capacity to interact with G protein-coupled receptors (GPCRs) has been largely unexplored.
Adel Abdollahnia +6 more
doaj +2 more sources
Frontiers in Pharmacology, 2023 Kappa opioid receptors have exceptional potential as an analgesic target, seemingly devoid of many problematic Mu receptor side-effects. Kappa-selective, small molecule pharmaceutical agents have been developed, but centrally mediated side-effects limit ...
Rink-Jan Lohman +4 more
doaj +1 more source
Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals
Frontiers in Neuroscience, 2022 Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Yoshihisa Uenoyama +4 more
doaj +1 more source
Biomolecules, 2020 Opioid peptides and receptors are broadly expressed throughout peripheral and central nervous systems and have been the subject of intense long-term investigations.
Ewa Gibula-Tarlowska +1 more
doaj +1 more source