Endogenous Opioid Peptides and Alternatively Spliced Mu Opioid Receptor Seven Transmembrane Carboxyl-Terminal Variants. [PDF]
Int J Mol Sci, 2021 There exist three main types of endogenous opioid peptides, enkephalins, dynorphins and β-endorphin, all of which are derived from their precursors. These endogenous opioid peptides act through opioid receptors, including mu opioid receptor (MOR), delta ...
Abrimian A, Kraft T, Pan YX.
europepmc +2 more sources
Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals
Frontiers in Neuroscience, 2022 Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Yoshihisa Uenoyama +4 more
doaj +1 more source
Biomolecules, 2020 Opioid peptides and receptors are broadly expressed throughout peripheral and central nervous systems and have been the subject of intense long-term investigations.
Ewa Gibula-Tarlowska +1 more
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Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]
, 2013 Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Murányi Marianna +25 more
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Dairy, 2022 The drug-likeness and pharmacokinetic properties of 23 dairy-protein-derived opioid peptides were studied using SwissADME and ADMETlab in silico tools. All the opioid peptides had poor drug-like properties based on violations of Lipinski’s rule-of-five ...
Dawei Ji +6 more
doaj +1 more source
Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils. [PDF]
PLoS Pathogens, 2009 In inflammation, pain is regulated by a balance of pro- and analgesic mediators. Analgesic mediators include opioid peptides which are secreted by neutrophils at the site of inflammation, leading to activation of opioid receptors on peripheral sensory ...
Heike L Rittner +9 more
doaj +1 more source
Involvement of the Opioid Peptide Family in Cancer Progression
Biomedicines, 2023 Peptides mediate cancer progression favoring the mitogenesis, migration, and invasion of tumor cells, promoting metastasis and anti-apoptotic mechanisms, and facilitating angiogenesis/lymphangiogenesis.
Manuel Lisardo Sánchez +2 more
doaj +1 more source
Peptidomimetics and Their Applications for Opioid Peptide Drug Discovery
Biomolecules, 2022 Despite various advantages, opioid peptides have been limited in their therapeutic uses due to the main drawbacks in metabolic stability, blood-brain barrier permeability, and bioavailability.
Yeon Sun Lee
doaj +1 more source
Opioid mediated activity and expression of mu and delta opioid receptors in isolated human term non-laboring myometrium [PDF]
, 2013 The existence of opioid receptors in mammalian myometrial tissue is now widely accepted. Previously enkephalin degrading enzymes have been shown to be elevated in pregnant rat uterus and a met-enkephalin analogue has been shown to alter spontaneous ...
McMorrow, Jason P. +5 more
core +1 more source
Probing protein sequences as sources for encrypted antimicrobial peptides [PDF]
, 2012 Starting from the premise that a wealth of potentially biologically active peptides may lurk within proteins, we describe here a methodology to identify putative antimicrobial peptides encrypted in protein sequences.
Francisco J. L. Aragão (132479) +31 more
core +1 more source