Results 21 to 30 of about 448,610 (243)

Probing protein sequences as sources for encrypted antimicrobial peptides [PDF]

, 2012
Starting from the premise that a wealth of potentially biologically active peptides may lurk within proteins, we describe here a methodology to identify putative antimicrobial peptides encrypted in protein sequences.
Francisco J. L. Aragão (132479), Jacques Nicoli (132482), Guilherme D Brand, Tinoco Maria L. P., Guilherme D. Brand (132470), Sharon M Kelly, Maria L P Tinoco, Brand, G.D., Jacques Nicoli, Mariana T. Q. Magalhães (132473), Francisco J L Aragão, Tinoco, M.L.P., Alan Cooper (9827), Cooper Alan, Nicoli, J., Carlos Bloch, Kelly Sharon M., Magalhães, M.T.Q., Sharon M. Kelly (132485), Kelly, S., Aragão, F.J.L., Bloch Jr, C., Brand Guilherme D., Aragão Francisco J. L., Maria L. P. Tinoco (132476), Magalhães Mariana T. Q., Alan Cooper, Bloch Carlos, Cooper, A., Mariana T Q Magalhães, Nicoli Jacques, Carlos Bloch Jr (132488)   +31 more
core   +1 more source

Opioid Receptors in Immune and Glial Cells—Implications for Pain Control

Frontiers in Immunology, 2020
Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Halina Machelska, Melih Ö. Celik
doaj   +1 more source

The role of respiratory failure caused by congenital central nervous system abnormalities and the effect of β-casomorphins in sudden infant death syndrome pathogenesis

Archives of Forensic Medicine and Criminology, 2015
The aim of the paper is to discuss the role of respiratory failure caused by endogenous (both structural and functional) abnormalities in the central nervous system and exogenous food-derived opioid-like peptides in the pathogenesis of sudden infant ...
Barbara Sumińska-Ziemann, Tomasz Gos, Zbigniew Jankowski   +2 more
doaj   +1 more source

Bioactive peptides in storage proteins

Grasas y Aceites, 2000
A review on the bioactive peptides described so far in storage proteins, mainly milk proteins, has been carried out. Bioactive peptides are small amino acid sequences inactives in the native protein, but that can be liberated after hydrolysis of these ...
J. Vioque, R. Sánchez-Vioque, A. Clemente, J. Pedroche, M. M. Yust, F. Millán   +5 more
doaj   +1 more source

The immune-opioid axis in prediabetes: predicting prediabetes with insulin resistance by plasma interleukin-10 and endomorphin-2 to kappa-opioid receptors ratio

Diabetology & Metabolic Syndrome, 2021
Background Prediabetes is characterized by a hemoglobin A1c of 5.7–6.4% and fasting blood glucose of 100–125 mg/dl. A high percentage of prediabetes subjects develop type 2 diabetes mellitus in the next years.
Shatha Rouf Moustafa
doaj   +1 more source

Opioid Peptides: Pharmaceutical Significance and Formulation Approaches

, 2023
Opioids have been used in pain management for thousands of years due to the pain relief effects that they show by binding to their own receptors. Nowadays, their use continues in a more controlled manner because they have various side effects and a ...
Selin Seda TİMUR, Muçaj, Stela, Engin, Demet, GÜRSOY, REYHAN NESLİHAN, Demet ENGİN, R. Neslihan GÜRSOY, TİMUR, SELİN SEDA, Stela MUÇAJ   +7 more
core   +1 more source

Opioid Peptides: Potential for Drug Development [PDF]

, 2012
Opioid receptors are important targets for the treatment of pain and potentially for other disease states (e.g. mood disorders and drug abuse) as well.
Jay P. McLaughlin, Aldrich, Jane V., McLaughlin, Jay P., Jane V. Aldrich   +3 more
core   +1 more source

Endogenous peripheral pain regulatory systems in orofacial pain patients

Saudi Dental Journal, 2019
Introduction: Initiation of pulpal pain begins with the release of bacterial toxins and inflammatory mediators that either activate or sensitize nociceptors thereby activating the trigeminal pain pathway.
Abdulmajeed M. Al Shujaa, Claudia O. Espitia, Qun Li, Mayor Patil, Nikita B. Ruparel   +4 more
doaj   +1 more source

Compartment-specific opioid receptor signaling is selectively modulated by different dynorphin peptides

eLife, 2021
Many signal transduction systems have an apparent redundancy built into them, where multiple physiological agonists activate the same receptors. Whether this is true redundancy, or whether this provides an as-yet unrecognized specificity in downstream ...
Jennifer M Kunselman, Achla Gupta, Ivone Gomes, Lakshmi A Devi, Manojkumar A Puthenveedu   +4 more
doaj   +1 more source

Targeting peripheral opioid receptors to promote analgesic and anti-inflammatory actions

Frontiers in Pharmacology, 2013
Mechanisms of endogenous pain control are significant. Increasing studies have clearly produced evidence for the clinical usefulness of opioids in peripheral analgesia.
Katerina eIwaszkiewicz, Jennifer eSchneider, Susan eHua   +2 more
doaj   +1 more source