Results 31 to 40 of about 416,668 (254)

In Silico and In Vitro Analysis of Multifunctionality of Animal Food-Derived Peptides

Foods, 2020
Currently, the associations between oxidative stress, inflammation, hypertension, and metabolic disturbances and non-communicable diseases are very well known.
Lourdes Amigo, Daniel Martínez-Maqueda, Blanca Hernández-Ledesma   +2 more
doaj   +1 more source

Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles

Molecules, 2020
The macrocyclic tetrapeptide cyclo[Phe-d-Pro-Phe-Trp] (CJ-15,208) and its stereoisomer cyclo[Phe-d-Pro-Phe-d-Trp] exhibit different opioid activity profiles in vivo.
Ariana C. Brice-Tutt, Sanjeewa N. Senadheera, Michelle L. Ganno, Shainnel O. Eans, Tanvir Khaliq, Thomas F. Murray, Jay P. McLaughlin, Jane V. Aldrich   +7 more
doaj   +1 more source

The Rural Opioid Initiative Consortium description: providing evidence to Understand the Fourth Wave of the Opioid Crisis

, 2022
OBJECTIVE: To characterize and address the opioid crisis disproportionately impacting rural U.S. regions. METHODS: The Rural Opioid Initiative (ROI) is a two-phase project to collect and harmonize quantitative and qualitative data and develop tailored ...
Stopka, Thomas J., Friedmann, Peter D., Feinberg, Judith, Westergaard, Ryan P., Tsui, Judith I., Cooper, Hannah L. F., Fredericksen, Rob, Rudolph|, Abby E. Rudolph, Joseph A. C. Delaney, Pho, Mai T., Thomas J. Stopka, Allen, Todd M., P. Todd Korthuis, Todd M. Allen, Hannah L. F. Cooper, Vivian F. Go, Seal, David W., Young, April M., Smith, Gordon S., Wiley D. Jenkins, Gordon S. Smith, Korthuis, P. T., null null, David W. Seal, Crane, Heidi M., Jenkins, Richard A., Miller, William C., Ryan P. Westergaard, Delaney, Joseph A. C., Jenkins, Wiley D., William A. Zule, Judith I. Tsui, Mai T. Pho, Rob Fredericksen, Judith Feinberg, Heidi M. Crane, Rudolph, Abby E., Nance, Robin M., Richard A. Jenkins, Robin M. Nance, Whitney, Bridget M., William C. Miller, Go, Vivian F., Bridget M. Whitney, April M. Young, Peter D. Friedmann, Rudolph, Abby, Korthuis, P. Todd, Zule, William A.   +49 more
core   +1 more source

Peripherally Acting Opioids in Orofacial Pain

Frontiers in Neuroscience, 2021
The activation of opioid receptors by exogenous or endogenous opioids can produce significant analgesic effects in peripheral tissues. Numerous researchers have demonstrated the expression of peripheral opioid receptors (PORs) and endogenous opioid ...
Qing Liu, Qing Liu, Hongwen He, Hongwen He, Lijia Mai, Lijia Mai, Shengyan Yang, Shengyan Yang, Wenguo Fan, Fang Huang, Fang Huang   +10 more
doaj   +1 more source

Production of bioactive peptides through sequencial action of Yarrowia lipolytica proteases and chemical glycation [PDF]

, 2013
This PhD thesis is aimed at studying the suitability of proteases realised by Yarrowia lipolytica to hydrolyse proteins of different origins available as industrial food by-products. Several strains of Y.
Gottardi, Davide <1983>
core   +1 more source

Analgesic effects of deltorphin analogues EW1 and EW2 in tail-immersion test in mice

Current Issues in Pharmacy and Medical Sciences, 2013
The aim of the study was to evaluate whether EW1 and EW2, the newly synthesized analogues of deltorphin, a highly potent mu- (MOP) and delta-opioid receptors (DOP) ligand, induce antinociceptive effects in the tail-immersion test after ...
Ewa Gibuła-Bruzda, Marta Marszałek, Ewa Witkowska, Jolanta H. Kotlińska   +3 more
doaj   +1 more source

Thymosin Beta 4 Is Involved in the Development of Electroacupuncture Tolerance

Frontiers in Cellular Neuroscience, 2019
Background: Electroacupuncture (EA) tolerance, a negative therapeutic effect, is a gradual decline in antinociception because of its repeated or prolonged use.
Juan Wan, Yi Ding, Sha Nan, Qiulin Zhang, Jinrui Sun, Chuanguang Suo, Mingxing Ding   +6 more
doaj   +1 more source

Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis. [PDF]

PLoS ONE, 2011
It is well known that the mu-opioid receptor (MOR) plays an important role in the rewarding properties of ethanol. However, it is less clear how chronic ethanol consumption affects MOR signaling.
Li He, Jennifer L Whistler
doaj   +1 more source

Beyond Charge: Field‐Effect Transistors in Multimodal Biosensing Platforms for Biomolecular Interaction Studies

Advanced Electronic Materials, EarlyView.
This review summarizes the developments in field‐effect transistor (FET)‐based dual‐mode sensor platforms and what can be learned from them. It identifies charge as a crucial factor in biomolecular interactions at interfaces, outlines the challenges of hybrid systems, and highlights their benefits.
Roger Hasler, Ciril Reiner‐Rozman, Christoph Kleber, Jakub Dostalek, Wolfgang Knoll   +4 more
wiley   +1 more source

Neuroimmune Interaction in the Regulation of Peripheral Opioid-mediated Analgesia in Inflammation

Frontiers in Immunology, 2016
Peripheral immune-cell-mediated analgesia in inflammation is an important endogenous mechanism of pain control. Opioid receptors localized on peripheral sensory nerve terminals are activated by endogenous opioid peptides released from immune cells to ...
Susan Hua
doaj   +1 more source