Results 31 to 40 of about 21,347 (246)

Endogenous opioids in wound-site neutrophils of sternotomy patients. [PDF]

PLoS ONE, 2012
Postoperative pain management is a critical aspect of patient care. The inflammatory state of the post-sternotomy surgical wound sensitizes nerve endings, causing pain. Unrelieved or improperly managed pain compromises wound healing.
Hamdy Awad, Motaz Abas, Haytham Elgharably, Ravi Tripathi, Tykie Theofilos, Sujatha Bhandary, Chittoor Sai-Sudhakar, Chandan K Sen, Sashwati Roy   +8 more
doaj   +1 more source

In Silico and In Vitro Analysis of Multifunctionality of Animal Food-Derived Peptides

Foods, 2020
Currently, the associations between oxidative stress, inflammation, hypertension, and metabolic disturbances and non-communicable diseases are very well known.
Lourdes Amigo, Daniel Martínez-Maqueda, Blanca Hernández-Ledesma   +2 more
doaj   +1 more source

Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles

Molecules, 2020
The macrocyclic tetrapeptide cyclo[Phe-d-Pro-Phe-Trp] (CJ-15,208) and its stereoisomer cyclo[Phe-d-Pro-Phe-d-Trp] exhibit different opioid activity profiles in vivo.
Ariana C. Brice-Tutt, Sanjeewa N. Senadheera, Michelle L. Ganno, Shainnel O. Eans, Tanvir Khaliq, Thomas F. Murray, Jay P. McLaughlin, Jane V. Aldrich   +7 more
doaj   +1 more source

Peripherally Acting Opioids in Orofacial Pain

Frontiers in Neuroscience, 2021
The activation of opioid receptors by exogenous or endogenous opioids can produce significant analgesic effects in peripheral tissues. Numerous researchers have demonstrated the expression of peripheral opioid receptors (PORs) and endogenous opioid ...
Qing Liu, Qing Liu, Hongwen He, Hongwen He, Lijia Mai, Lijia Mai, Shengyan Yang, Shengyan Yang, Wenguo Fan, Fang Huang, Fang Huang   +10 more
doaj   +1 more source

Opioid Peptides: Potential for Drug Development [PDF]

, 2012
Opioid receptors are important targets for the treatment of pain and potentially for other disease states (e.g. mood disorders and drug abuse) as well.
Jay P. McLaughlin, Aldrich, Jane V., McLaughlin, Jay P., Jane V. Aldrich   +3 more
core   +1 more source

Analgesic effects of deltorphin analogues EW1 and EW2 in tail-immersion test in mice

Current Issues in Pharmacy and Medical Sciences, 2013
The aim of the study was to evaluate whether EW1 and EW2, the newly synthesized analogues of deltorphin, a highly potent mu- (MOP) and delta-opioid receptors (DOP) ligand, induce antinociceptive effects in the tail-immersion test after ...
Ewa Gibuła-Bruzda, Marta Marszałek, Ewa Witkowska, Jolanta H. Kotlińska   +3 more
doaj   +1 more source

Degradation of food-derived opioid peptides by bifidobacteria

, 2018
Some food-derived opioid peptides have been reported to cause diseases, such as gastrointestinal inflammation, celiac disease, and mental disorders.
N. Hashikura, J.-Z. Xiao, A. Yamada, T. Sakurai, T. Odamaki   +4 more
core   +1 more source

Thymosin Beta 4 Is Involved in the Development of Electroacupuncture Tolerance

Frontiers in Cellular Neuroscience, 2019
Background: Electroacupuncture (EA) tolerance, a negative therapeutic effect, is a gradual decline in antinociception because of its repeated or prolonged use.
Juan Wan, Yi Ding, Sha Nan, Qiulin Zhang, Jinrui Sun, Chuanguang Suo, Mingxing Ding   +6 more
doaj   +1 more source

Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis. [PDF]

PLoS ONE, 2011
It is well known that the mu-opioid receptor (MOR) plays an important role in the rewarding properties of ethanol. However, it is less clear how chronic ethanol consumption affects MOR signaling.
Li He, Jennifer L Whistler
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source