Results 31 to 40 of about 448,610 (243)

Endogenous opioids in wound-site neutrophils of sternotomy patients. [PDF]

PLoS ONE, 2012
Postoperative pain management is a critical aspect of patient care. The inflammatory state of the post-sternotomy surgical wound sensitizes nerve endings, causing pain. Unrelieved or improperly managed pain compromises wound healing.
Hamdy Awad, Motaz Abas, Haytham Elgharably, Ravi Tripathi, Tykie Theofilos, Sujatha Bhandary, Chittoor Sai-Sudhakar, Chandan K Sen, Sashwati Roy   +8 more
doaj   +1 more source

Toll like Receptor (TLR)-4 as a Regulator of Peripheral Endogenous Opioid-Mediated Analgesia in Inflammation

Molecular Pain, 2014
Background: Leukocytes containing opioid peptides locally control inflammatory pain. In the early phase of complete Freund's adjuvant (CFA)-induced hind paw inflammation, formyl peptides (derived e.g. from Mycobacterium butyricum ) trigger the release of
Reine-Solange Sauer, Dagmar Hackel, Laura Morschel, Henrike Sahlbach, Ying Wang, Shaaban A Mousa, Norbert Roewer, Alexander Brack, Heike L Rittner   +8 more
doaj   +1 more source

In Silico and In Vitro Analysis of Multifunctionality of Animal Food-Derived Peptides

Foods, 2020
Currently, the associations between oxidative stress, inflammation, hypertension, and metabolic disturbances and non-communicable diseases are very well known.
Lourdes Amigo, Daniel Martínez-Maqueda, Blanca Hernández-Ledesma   +2 more
doaj   +1 more source

Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles

Molecules, 2020
The macrocyclic tetrapeptide cyclo[Phe-d-Pro-Phe-Trp] (CJ-15,208) and its stereoisomer cyclo[Phe-d-Pro-Phe-d-Trp] exhibit different opioid activity profiles in vivo.
Ariana C. Brice-Tutt, Sanjeewa N. Senadheera, Michelle L. Ganno, Shainnel O. Eans, Tanvir Khaliq, Thomas F. Murray, Jay P. McLaughlin, Jane V. Aldrich   +7 more
doaj   +1 more source

Effects of chronic treatment with atypical neuroleptics on the biosynthesis and release of opioid peptides in guinea-pig ileum

, 1985
The guinea-pig ileum myenteric plexus is known to contain opioid peptides, which can be released by electric stimulation at high frequency. Haloperidol, a classic neuroleptic drug, increases the biosynthesis and release of endogenous opioid peptides from
Martínez, J. A., Brugger, A. J., Milanés, M. V., Vargas, M. L., Pérez, D.   +4 more
core   +1 more source

Analgesic effects of deltorphin analogues EW1 and EW2 in tail-immersion test in mice

Current Issues in Pharmacy and Medical Sciences, 2013
The aim of the study was to evaluate whether EW1 and EW2, the newly synthesized analogues of deltorphin, a highly potent mu- (MOP) and delta-opioid receptors (DOP) ligand, induce antinociceptive effects in the tail-immersion test after ...
Ewa Gibuła-Bruzda, Marta Marszałek, Ewa Witkowska, Jolanta H. Kotlińska   +3 more
doaj   +1 more source

Peripherally Acting Opioids in Orofacial Pain

Frontiers in Neuroscience, 2021
The activation of opioid receptors by exogenous or endogenous opioids can produce significant analgesic effects in peripheral tissues. Numerous researchers have demonstrated the expression of peripheral opioid receptors (PORs) and endogenous opioid ...
Qing Liu, Qing Liu, Hongwen He, Hongwen He, Lijia Mai, Lijia Mai, Shengyan Yang, Shengyan Yang, Wenguo Fan, Fang Huang, Fang Huang   +10 more
doaj   +1 more source

Thymosin Beta 4 Is Involved in the Development of Electroacupuncture Tolerance

Frontiers in Cellular Neuroscience, 2019
Background: Electroacupuncture (EA) tolerance, a negative therapeutic effect, is a gradual decline in antinociception because of its repeated or prolonged use.
Juan Wan, Yi Ding, Sha Nan, Qiulin Zhang, Jinrui Sun, Chuanguang Suo, Mingxing Ding   +6 more
doaj   +1 more source

Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis. [PDF]

PLoS ONE, 2011
It is well known that the mu-opioid receptor (MOR) plays an important role in the rewarding properties of ethanol. However, it is less clear how chronic ethanol consumption affects MOR signaling.
Li He, Jennifer L Whistler
doaj   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source