Results 201 to 210 of about 21,347 (246)
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Cyclization in Opioid Peptides
Current Drug Targets, 2013Endogenous opioid peptides have been studied extensively as potential therapeutics for the treatment of pain. The major problems of using natural opioid peptides as drug candidates are their poor receptor specificity, metabolic instability and inability to reach the brain after systemic administration.
Justyna, Piekielna +3 more
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The hemorphins: A new class of opioid peptides derived from the blood protein hemoglobin
Biopolymers, 1997 Hemorphins are endogenous peptides belonging to the family of ''nonclassical'' or ''atypical'' opioid peptides. They are generated by enzymatic hydrolysis of the beta-, kappa-, delta-, or epsilon-chain of the blood protein hemoglobin.
Fred Nyberg
exaly +1 more source
Alcohol health and research world, 2005
Opioid peptides produced in the body act as neuromodulators that modify the actions of other neurotransmitters in the central nervous system. By altering the electrical properties of their target neurons, thereby making these neurons more difficult to excite, opioid peptides can influence the release of various neurotransmitters.
Daniel Daniel Tomé +2 more
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Opioid peptides produced in the body act as neuromodulators that modify the actions of other neurotransmitters in the central nervous system. By altering the electrical properties of their target neurons, thereby making these neurons more difficult to excite, opioid peptides can influence the release of various neurotransmitters.
Daniel Daniel Tomé +2 more
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Opioid receptors and endogenous opioid peptides
Medicinal Research Reviews, 1991The field to be reviewed is now 16 years old and is based on knowledge dating back centuries. It is therefore evident that an exhaustive review is impossible. The author plans to discuss areas likely to be of interest to the readers of this journal.
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Biosynthesis of Opioid Peptides
1990The endogenous opioid peptides all contain the enkephalin sequence Tyr-Gly-Gly-Phe-Met and Tyr-Gly-Gly-Phe-Leu at their aminoterminus. Three distinct families of these peptides (endorphins, enkephalins and dynorphins) are present in different neuronal pathways within the central nervous system. Molecular genetics have shown that these three families of
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1988
The discovery of endogenous opioids has begun an intricate saga involving multiple ligands and multiple receptors that form an extensive neuronal network in both the central and peripheral nervous systems. This intricacy is reflected in the complex pharmacology and diverse physiological effects of opioids in mammals.
Christopher J. Evans +2 more
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The discovery of endogenous opioids has begun an intricate saga involving multiple ligands and multiple receptors that form an extensive neuronal network in both the central and peripheral nervous systems. This intricacy is reflected in the complex pharmacology and diverse physiological effects of opioids in mammals.
Christopher J. Evans +2 more
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Expression of Opioid Peptides in Tumors
New England Journal of Medicine, 1987We looked for opioid peptides and their precursors in 108 tumors of both neuroendocrine and nonneuroendocrine origin, using a monoclonal "pan-opioid" antibody, 3-E7, which recognizes the tetrapeptide Tyr-Gly-Gly-Phe (the sequence responsible for pharmacologic activity in all known opioid peptides), in conjunction with polyclonal antibodies directed ...
D G, Bostwick +5 more
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Biosynthesis and distribution of opioid peptides
Journal of Endocrinological Investigation, 1983Group III opioid peptides are derived from proenkephalin B. The processing of this precursor peptide is still only partly understood and we still do not know how many final products come from proenkephalin B and whether Leu-enkephalin is produced from Group III peptides.
H, Imura +10 more
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Palatal myoclonus and opioid peptides
Acta Neurologica Scandinavica, 2009We report a patient who presented palatal myoclonus (PM) after anoxic brain damage that was completely abolished by the administration of opioid agonists. This suggests the involvement of peptide systems in the development of PM.
E, Martínez-Vila +3 more
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Endogenous opioid peptides in pregnancy
BJOG: An International Journal of Obstetrics & Gynaecology, 1983Summary. Plasma levels of two endogenous opioid peptides, β‐endorphin and met‐enkephalin, as well as immunoreactive N‐terminal β‐lipotrophin (N‐LPH) were studied in normal pregnant women from 8 to 41 weeks gestation. A total of 116 samples were assayed for β‐endorphin‐like immunoreactivity (C‐LPH), 103 for N‐LPH and 75 for met‐enkephalin.
J P, Newnham +4 more
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