Results 201 to 210 of about 448,610 (243)

Opioid Peptides and their Receptors

1982
The three agonists, methionine-enkephalin, leucine-enkephalin and beta-endorphin have different pharmacological patterns. It may be of particular importance that they vary in their relative affinities to the enkephalin and naltrexone binding sites in the brain; the former are probably related to delta-receptors prevalent in the mouse vas deferens and ...
H.W. Kosterlitz, S.J. Paterson, L.E. Robson   +2 more
openaire   +2 more sources

Cyclization in Opioid Peptides

Current Drug Targets, 2013
Endogenous opioid peptides have been studied extensively as potential therapeutics for the treatment of pain. The major problems of using natural opioid peptides as drug candidates are their poor receptor specificity, metabolic instability and inability to reach the brain after systemic administration.
Justyna, Piekielna, Renata, Perlikowska, Katarzyna, Gach, Anna, Janecka   +3 more
openaire   +2 more sources

Opioid peptides.

Alcohol health and research world, 2005
Opioid peptides produced in the body act as neuromodulators that modify the actions of other neurotransmitters in the central nervous system. By altering the electrical properties of their target neurons, thereby making these neurons more difficult to excite, opioid peptides can influence the release of various neurotransmitters.
Daniel Daniel Tomé, Lisa Pichon, Benjamin Guesdon   +2 more
openaire   +3 more sources

Opioid receptors and endogenous opioid peptides

Medicinal Research Reviews, 1991
The field to be reviewed is now 16 years old and is based on knowledge dating back centuries. It is therefore evident that an exhaustive review is impossible. The author plans to discuss areas likely to be of interest to the readers of this journal.
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Biosynthesis of Opioid Peptides

1990
The endogenous opioid peptides all contain the enkephalin sequence Tyr-Gly-Gly-Phe-Met and Tyr-Gly-Gly-Phe-Leu at their aminoterminus. Three distinct families of these peptides (endorphins, enkephalins and dynorphins) are present in different neuronal pathways within the central nervous system. Molecular genetics have shown that these three families of
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The Opioid Peptides

1988
The discovery of endogenous opioids has begun an intricate saga involving multiple ligands and multiple receptors that form an extensive neuronal network in both the central and peripheral nervous systems. This intricacy is reflected in the complex pharmacology and diverse physiological effects of opioids in mammals.
Christopher J. Evans, Donna L. Hammond, Robert C. A. Frederickson   +2 more
openaire   +1 more source

Biosynthesis and distribution of opioid peptides

Journal of Endocrinological Investigation, 1983
Group III opioid peptides are derived from proenkephalin B. The processing of this precursor peptide is still only partly understood and we still do not know how many final products come from proenkephalin B and whether Leu-enkephalin is produced from Group III peptides.
H, Imura, Y, Nakai, K, Nakao, S, Oki, I, Tanaka, H, Jingami, T, Yoshimasa, T, Tsukada, Y, Ikeda, M, Suda, M, Sakamoto   +10 more
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Opioid Receptor Independent Effects of Opioid Peptides

Current Reviews in Clinical and Experimental Pharmacology
Abstract: Almost immediately after the discovery of opioid peptides and opioid receptors (ORs), reports were published that some effects of opioid peptides are independent of the activation of ORs. It was demonstrated that Des-Tyr1-fragments of opioid peptides did not interact with ORs but can exert different ...
Leonid N, Maslov, Alexander V, Mukhomedzyanov, Alisa S, Slidnevskaya, Alexander S, Gorbunov, Sergey V, Popov, Artur, Kan, Natalia V, Naryzhnaya, Feng, Fu, Philipp A, Ilinykh, Viacheslav N, Azev, Huijie, Ma   +10 more
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Opioid peptides

Life Sciences, 1980
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Opioid Peptides and Aging

Annals of the New York Academy of Sciences, 1990
J E, Morley, J F, Flood, A J, Silver
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