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Immunomodulatory effects of endogenous and synthetic peptides activating opioid receptors.
Mini-Reviews in Medical Chemistry, 2014The main role of endogenous opioid peptides is the modulation of pain. Opioid peptides exert their analgesic activity by binding to the opioid receptors distributed widely in the central nervous system (CNS).
D. Pomorska, K. Gach, A. Janecka
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Biosynthesis and distribution of opioid peptides [PDF]
Journal of Endocrinological Investigation, 1983 Group III opioid peptides are derived from proenkephalin B. The processing of this precursor peptide is still only partly understood and we still do not know how many final products come from proenkephalin B and whether Leu-enkephalin is produced from Group III peptides.
I. Tanaka +10 more
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Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity.
Science, 1984The cytotoxic activity of natural killer cells was investigated in rats subjected to one of two inescapable footshock stress paradigms, both of which induce analgesia, but only one via activation of opioid mechanisms. Splenic natural killer cell activity
Y. Shavit +4 more
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Science, 1979
The atypical excitation by opiates and opioid peptides of hippocampal pyramidal cells can be antagonized by iontophoresis of naloxone, the gamma-aminobutyric acid antagonists bicuculline, or magnesium ion.
W. Zieglgänsberger +4 more
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The atypical excitation by opiates and opioid peptides of hippocampal pyramidal cells can be antagonized by iontophoresis of naloxone, the gamma-aminobutyric acid antagonists bicuculline, or magnesium ion.
W. Zieglgänsberger +4 more
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Separation of opioid peptides utilizing high performance liquid chromatography.
International journal of peptide & protein research, 2009Chromatographic procedures have been developed for resolving all of the known enkephalins and endorphins on a single column. The effect of eluant pH on the retention times and separation of the enkephalins and beta-endorphin was determined.
R. Lewis, S. Stein, S. Udenfriend
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Expression of Opioid Peptides in Tumors
New England Journal of Medicine, 1987We looked for opioid peptides and their precursors in 108 tumors of both neuroendocrine and nonneuroendocrine origin, using a monoclonal "pan-opioid" antibody, 3-E7, which recognizes the tetrapeptide Tyr-Gly-Gly-Phe (the sequence responsible for pharmacologic activity in all known opioid peptides), in conjunction with polyclonal antibodies directed ...
Klaus G. Bensch +5 more
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Alcoholism: Clinical and Experimental Research, 2009
BACKGROUND Experimental evidence suggests that ethanol alters the activity of the endogenous opioid peptide systems in a dose and brain-region dependent manner. These alterations may influence the processes of ethanol reward and reinforcement.
Samuel Jarjour, Li Bai, C. Gianoulakis
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BACKGROUND Experimental evidence suggests that ethanol alters the activity of the endogenous opioid peptide systems in a dose and brain-region dependent manner. These alterations may influence the processes of ethanol reward and reinforcement.
Samuel Jarjour, Li Bai, C. Gianoulakis
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Biosynthesis of Opioid Peptides
1990The endogenous opioid peptides all contain the enkephalin sequence Tyr-Gly-Gly-Phe-Met and Tyr-Gly-Gly-Phe-Leu at their aminoterminus. Three distinct families of these peptides (endorphins, enkephalins and dynorphins) are present in different neuronal pathways within the central nervous system. Molecular genetics have shown that these three families of
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Chapter 18 Nicotine and opioid peptides
1989Publisher Summary This chapter discusses the relationship between nicotinic cholinergic receptors and opioid peptides. Nicotine appears to exert its stimulatory effect most likely at the level of the hypothalamus by causing a release of corticotropin releasing factor.
Gabriele Horn, V. Höllt
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