Results 91 to 100 of about 2,542,870 (405)
The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking. [PDF]
, 2015 Distinct environmental and conditioned stimuli influencing ethanol-associated appetitive and consummatory behaviors may jointly contribute to alcohol addiction.
Belin, David +7 more
core +4 more sources
Opioids and opioid receptors orchestrate wound repair [PDF]
Translational Research, 2017 We have previously shown that topical opioids including morphine and its congeners promote healing of full thickness ischemic wounds in rats. We examined the contribution of mu opioid receptor (MOPr)-mediated healing of full thickness ischemic wounds using MOPr and delta or kappa opioid receptor knockout (KO) mice. Wound closure in the early (day 5) as
Kalpna Gupta +9 more
openaire +3 more sources
American Journal of Industrial Medicine, EarlyView.ABSTRACT Objective Substance use right before or during work (hereinafter, “substance use in the workplace”) poses significant health risks to users, colleagues, and the public in the workplace. However, less clear are figures on recent prevalence, characteristics of those engaging in such behaviors, and variations across occupations.
Sehun Oh +2 more
wiley +1 more source
µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice
Translational PsychiatryMood and anxiety disorders are leading causes of disability worldwide and are major contributors to the global burden of diseases. Neuropeptides, such as oxytocin and opioid peptides, are important for emotion regulation.
Khalin E. Nisbett +2 more
doaj +1 more source
Dopamine D3 Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats. [PDF]
, 2019 Prescription opioids, such as oxycodone, are highly effective analgesics for clinical pain management, but approximately 25% of patients who are prescribed opioids misuse them, and 5%-10% develop an opioid use disorder (OUD).
de Guglielmo, Giordano +4 more
core
Multiple opioid receptor-like genes are identified in diverse vertebrate phyla [PDF]
, 1996 Polymerase chain reaction was used to determine whether opioid receptor-like sequences are present in species from the protostome and deuterostome branches of the metazoan kingdom.
Evans, Christopher J. +2 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.Neuropathic pain management via repeated electroacupuncture. Abstract Background Existing remedial approaches for relieving neuropathic pain (NPP) are challenging and open the way for alternative therapeutic measures such as electroacupuncture (EA). The mechanism underlying the antinociceptive effects of repeated EA sessions, particularly concerning ...
Faisal Ayub Kiani +6 more
wiley +1 more source
The Journal of Poultry ScienceFreedom from thirst is an undeniable requirement of the poultry industry. However, the regulatory mechanisms underlying water intake in chicks are not yet fully understood.
Yuhui Zhang +4 more
doaj +1 more source
The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice. [PDF]
, 2015 RATIONALE Using the drinking-in-the-dark (DID) model, we compared the effects of a novel mu-opioid receptor antagonist, GSK1521498, with naltrexone, a licensed treatment of alcohol dependence, on ethanol consumption in mice.
C Giuliano +33 more
core +1 more source
Better agonist for the opioid receptors [PDF]
Chemistry Central Journal, 2018 This commentary highlights the recent work published in journal Nature on the structural based discovery of novel analgesic compounds for opioid receptors with minimal effects. Manglik et al. selectively targeted the Gi based μOR pathway instead of the β-arrestin pathway of the opioids. The computational screening of millions of compounds showed a list
Syed Lal Badshah +3 more
openaire +3 more sources