Results 111 to 120 of about 2,577,172 (407)
Genome Biology, 2001 Mouse μ-opioid receptor carboxy-terminal splice variants have been shown to differ in their responses to agonists.
openaire +2 more sources
Advanced Science, EarlyView.Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan +9 more
wiley +1 more source
Ibrain, EarlyView., 2023 This study compared the clinical effectiveness and treatment satisfaction of Pregabalin and Gabapentin triple therapy for neuropathic pain in a real‐world setting. The primary outcome measured the reduction in mean Self‐Administered Leeds Assessment of Neuropathic Symptoms and Signs pain score value from baseline to 12 weeks posttreatment.
Nithya Raju +7 more
wiley +1 more source
Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain [PDF]
, 2006 Cannabinoid-based medicines have therapeutic potential for the treatment of pain. Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states.
Barrett, David +4 more
core +2 more sources
The role of the dynorphin/κ opioid receptor system in anxiety
Acta Pharmacologica Sinica, 2015 Anxiety disorders are the most common and prevalent forms of psychiatric disease, although the biological basis of anxiety is not well understood. The dynorphin/κ opioid receptor system is widely distributed in the central nervous system and has been ...
Ai Y. Hang +3 more
semanticscholar +1 more source
American Journal of Community Psychology, EarlyView.Abstract Youth participatory action research (YPAR) has been effectively used for substance use prevention. Yet, YPAR has not been evaluated for opioids, which negatively impact individuals and communities across the United States. The current study evaluated an opioid‐focused YPAR project.
Elizabeth H. Weybright +7 more
wiley +1 more source
Alcohol addiction: a molecular biology perspective. [PDF]
, 2015 Alcohol misuse represents worldwide an important risk factor for death and disability. Excessive alcohol consumption is widely diffused in different ethnicities and alcohol use is part of the lifestyle of both young and old people.
Ferraguti, Giampiero +2 more
core +1 more source
The genomics of neonatal abstinence syndrome [PDF]
, 2017 Significant variability has been observed in the development and severity of neonatal abstinence syndrome (NAS) among neonates exposed to prenatal opioids.
Cole, F. Sessions +2 more
core +3 more sources
British Journal of Clinical Pharmacology, EarlyView.Aims At Koç University School of Medicine, a one‐week rational pharmacotherapy (RPHM) programme, modelled after WHO 6‐step, has been introduced in the fourth‐year curriculum to improve prescription skills. For efficient problem‐based learning (PBL) sessions on a prespecified topic, students need to brush up on basic pharmacology knowledge, so we ...
Sinem Ezgi Gülmez +2 more
wiley +1 more source
Nitrous Oxide: Mechanism of Its Antinociceptive Action [PDF]
, 1995 Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated.
Quock, Raymond M., Vaughn, Linda K.
core +1 more source