Results 111 to 120 of about 2,513,925 (427)

Solid Tumor Opioid Receptor Expression and Oncologic Outcomes: Analysis of the Cancer Genome Atlas and Genotype Tissue Expression Project

Frontiers in Oncology, 2022
BackgroundOpioid receptors are expressed not only by neural cells in the central nervous system, but also by many solid tumor cancer cells. Whether perioperative opioids given for analgesia after tumor resection surgery might inadvertently activate tumor
Amparo Belltall, Amparo Belltall, Sheila Zúñiga-Trejos, Iris Garrido-Cano, Iris Garrido-Cano, Pilar Eroles, Pilar Eroles, Maria Pilar Argente-Navarro, Maria Pilar Argente-Navarro, Donal J. Buggy, Donal J. Buggy, Oscar Díaz-Cambronero, Oscar Díaz-Cambronero, Oscar Díaz-Cambronero, Guido Mazzinari, Guido Mazzinari, Guido Mazzinari   +16 more
doaj   +1 more source

Multiple opioid receptor-like genes are identified in diverse vertebrate phyla [PDF]

, 1996
Polymerase chain reaction was used to determine whether opioid receptor-like sequences are present in species from the protostome and deuterostome branches of the metazoan kingdom.
Evans, Christopher J., Keith, Duane E., Li, Xia   +2 more
core   +1 more source

Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems

Pharmacological Reviews, 2016
The NOP receptor (nociceptin/orphanin FQ opioid peptide receptor) is the most recently discovered member of the opioid receptor family and, together with its endogenous ligand, N/OFQ, make up the fourth members of the opioid receptor and opioid peptide ...
L. Toll, M. Bruchas, G. Calo’, B. Cox, N. Zaveri   +4 more
semanticscholar   +1 more source

The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model

Advanced Science, EarlyView.
Intratracheal neomycin alters pulmonary microbiota, activating the vagus nerve via lung brain‐derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) pathway, further projecting to nucleus of solitary tract (NTS), then dorsal raphe nucleus (DRN), where activated serotoninergic neurons increase brain serotonin, alleviating migraine.
Biying Liu, Chengya Huang, Xin Li, Haonan Yu, Yuefeng Xia, Kun Liu, Xingji You, Jingxiang Wu   +7 more
wiley   +1 more source

Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy

Nature Communications, 2021
Mitragynine (MG) is an indole alkaloid from kratom plant that binds opioid receptors and as such presents a scaffold for the development of atypical opioid receptor modulators.
Srijita Bhowmik, Juraj Galeta, Václav Havel, Melissa Nelson, Abdelfattah Faouzi, Benjamin Bechand, Mike Ansonoff, Tomas Fiala, Amanda Hunkele, Andrew C. Kruegel, John. E. Pintar, Susruta Majumdar, Jonathan A. Javitch, Dalibor Sames   +13 more
doaj   +1 more source

Structural basis for bifunctional peptide recognition at human δ-Opioid receptor

Nature Structural &Molecular Biology, 2015
Bifunctional μ- and δ-opioid receptor (OR) ligands are potential therapeutic alternatives, with diminished side effects, to alkaloid opiate analgesics.
G. Fenalti, N. Zatsepin, Cecilia Betti, P. Giguère, G. Han, A. Ishchenko, Wei Liu, Karel Guillemyn, Haitao Zhang, Daniel James, Dingjie Wang, U. Weierstall, J. Spence, S. Boutet, M. Messerschmidt, Garth J. Williams, C. Gati, O. Yefanov, T. White, D. Oberthuer, M. Metz, C. Yoon, A. Barty, H. Chapman, S. Basu, J. Coe, C. Conrad, R. Fromme, P. Fromme, D. Tourwé, P. Schiller, B. Roth, S. Ballet, V. Katritch, R. Stevens, V. Cherezov   +35 more
semanticscholar   +1 more source

S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2

Advanced Science, EarlyView.
S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang   +7 more
wiley   +1 more source

Molecular motion in cell membranes: analytic study of fence-hindered random walks [PDF]

, 2008
A theoretical calculation is presented to describe the confined motion of transmembrane molecules in cell membranes. The study is analytic, based on Master equations for the probability of the molecules moving as random walkers, and leads to explicit usable solutions including expressions for the molecular mean square displacement and effective ...
arxiv   +1 more source

US employment exposure to domestic and foreign tariff changes under NAFTA

Applied Economic Perspectives and Policy, EarlyView.
Abstract Literature examining the effects of changes in trade agreements and import competition on US employment and wages has focused primarily on non‐agricultural industries and changes in US import tariffs. We propose a method for measuring worker exposure to changes in agricultural tariffs using a newly developed county‐level dataset of employment ...
Diane E. Charlton, Amanda M. Countryman, Dale T. Manning, Sionegael Ikeme   +3 more
wiley   +1 more source

Effects of Central Administration of Opioid Peptides, Vasotocin, Mesotocin, and Corticotrophin-Releasing Factor on Water Intake in Chicks

The Journal of Poultry Science
Freedom from thirst is an undeniable requirement of the poultry industry. However, the regulatory mechanisms underlying water intake in chicks are not yet fully understood.
Yuhui Zhang, Kaoruko Murata, Junya Takegaki, Takaoki Saneyasu, Kazuhisa Honda   +4 more
doaj   +1 more source