Results 121 to 130 of about 2,577,172 (407)

Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma. [PDF]

, 2020
Despite the large comorbidity between PTSD and opioid use disorders, as well as the common treatment of physical injuries resulting from trauma with opioids, the ability of opioid treatments to subsequently modify PTSD-related behavior has not been well ...
Evans, Christopher J, Fanselow, Michael S, Li, Kevin, Pennington, Zachary T, Rajbhandari, Abha K, Trott, Jeremy M, Walwyn, Wendy M   +6 more
core   +1 more source

Caenorhabditis elegans as a model system to identify therapeutics for alcohol use disorders [PDF]

, 2019
Alcohol use disorders (AUDs) cause serious problems in society and few effective treatments are available. Caenorhabditis elegans (C. elegans) is an excellent invertebrate model to study the neurobiological basis of human behavior with a conserved, fully
Bell, Richard L., Bredhold, Kristin E., Cheong, Mi C., Engleman, Eric A., Katner, Simon N., Neal-Beliveau, Bethany S., Steagall, Kevin B., III   +6 more
core   +1 more source

Trends in analgesia prescribing in primary care in Ireland and England between 2014 and 2022: A repeated cross‐sectional study

British Journal of Clinical Pharmacology, EarlyView.
Aims Analgesic medicines are an important component of pain management, with different medicines carrying different risks and benefits. The aim of this study was to examine trends in analgesic prescribing in Ireland and England between 2014 and 2022. Methods Monthly data on medicines prescribed and dispensed in primary care were used. For Ireland, data
Molly Mattsson, Michelle Flood, Brian MacKenna, Emma Wallace, Fiona Boland, Ciara Kirke, Mary E. Walsh, Tom Fahey, Frank Moriarty   +8 more
wiley   +1 more source

Molecular Aspects of Opioid Receptors and Opioid Receptor Painkillers

, 2012
The unpleasant sensation of pain is experienced by all human beings at a given point in life. When pain gets severe and/or chronic it requires medical treatment. For over a thousand years, opioid agonists have been employed therapeutically to treat pain, with the first reports of such use involving the alkaloid morphine dated to the second century B.C.(
Austin B. Yongye, Karina Martinez-Mayorga   +1 more
openaire   +4 more sources

Deletion of arrestin-3 does not reduce drug-seeking behavior in a longitudinal paradigm of oral morphine self-administration

Frontiers in Pharmacology
IntroductionOpioid drugs are potent analgesics that mimic the endogenous opioid peptides, endorphins and enkephalins, by activating the µ-opioid receptor.
Sarah Warren Gooding, Lindsey Felth, Randi Foxall, Zachary Rosa, Kyle Ireton, Izabella Sall, Joshua Gipoor, Anirudh Gaur, Madeline King, Noah Dirks, Cheryl Allyne Whistler, Jennifer Lynne Whistler, Jennifer Lynne Whistler   +12 more
doaj   +1 more source

Investigating the KNDy hypothesis in humans by co-administration of kisspeptin, neurokinin B and naltrexone in men [PDF]

, 2016
Context: A subpopulation of hypothalamic neurons co-localise three neuropeptides namely kisspeptin, neurokinin B (NKB) and dynorphin collectively termed KNDy neurons. Animal studies suggest they interact to affect pulsatile GnRH release (KNDy hypothesis);
Abbara, A, Bassett, P, Bloom, S, COMNINOS, A, Dhillo, WS, Jayasena, C, Mizamtsidi, M, Narayanaswamy, S, Papadopoulou, D, Prague, J, Shah, A, Veldhuis, J   +11 more
core   +1 more source

Trends in opioid prescribing in Scandinavian countries from 2010 to 2023: Insights from multi‐metric evaluation

British Journal of Clinical Pharmacology, EarlyView.
Aims Monitoring opioid prescribing across different healthcare systems is essential to understanding population‐level exposure and informing global health policies. This study examined opioid utilization in Scandinavian countries between 2010 and 2023 using multiple complementary metrics, addressing the limitations of single‐metric comparisons ...
Gabriela Rolová, Svetlana Skurtveit, Marte Handal, Geana Paula Kurita, Torgeir Gilje Lid, Ingvild Odsbu, Mikael Hoffmann   +6 more
wiley   +1 more source

A mu–delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks

Brain Structure and Function, 2014
Opioid receptors are G protein-coupled receptors (GPCRs) that modulate brain function at all levels of neural integration, including autonomic, sensory, emotional and cognitive processing.
E. Erbs, L. Faget, G. Scherrer, A. Matifas, D. Filliol, J. Vonesch, M. Koch, P. Kessler, D. Hentsch, M. Birling, M. Koutsourakis, Laurent Vasseur, P. Veinante, B. Kieffer, D. Massotte   +14 more
semanticscholar   +1 more source

Efficacy and safety of a selective partial agonist for nociception/orphanin‐FQ peptide (NOP) receptors in patients with insomnia disorder

British Journal of Clinical Pharmacology, EarlyView.
Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside, Ellie He, Manjunath S. Shet, Mingyan Zhou, Maha Ahmad, Stephen C. Harris   +5 more
wiley   +1 more source

Endogenous opioids regulate moment-to-moment neuronal communication and excitability

Nature Communications, 2017
The endogenous opioid system regulates fear and anxiety, but the underlying cellular mechanism is unclear. Winterset al. shows that in the intercalated cells (ITC) of the amygdala, endogenous opioids suppress glutamatergic inputs via the δ-opioid ...
Bryony L. Winters, Gabrielle C. Gregoriou, Sarah A. Kissiwaa, Oliver A. Wells, Danashi I. Medagoda, Sam M. Hermes, Neil T. Burford, Andrew Alt, Sue A. Aicher, Elena E. Bagley   +9 more
doaj   +1 more source