Results 141 to 150 of about 1,391,378 (297)

Naloxone antagonizes the local antihyperalgesic effect of fentanyl in burnt skin of healthy humans [PDF]

, 2007
The aim of this study was to investigate local opioid effects in the inflamed skin of healthy human volunteers. To induce inflammation, the circular tip of a 10-mm-diameter probe was heated to 48°C and applied for 120 seconds to a site on each forearm of
Hammond, G.R., Drummond, P.D., Robertson, L.   +2 more
core  

Advances in New Approach Methodologies at FDA's Division of Applied Regulatory Science

Clinical Pharmacology &Therapeutics, EarlyView.
New Approach Methodologies (NAMs) represent a paradigm shift in drug development and regulatory science, offering human‐relevant alternatives to traditional preclinical models. This mini‐review highlights recent advances in NAM development, validation, and regulatory application from FDA's Division of Applied Regulatory Science (DARS).
Ksenia Blinova, Kimberly Chiu, Anik Chaturbedi, Jahan Cooper, Tromondae K. Feaster, Paula L. Hyland, Lidiya Stavitskaya, Wendy W. Wu, Jeffry Florian, Rodney Rouse   +9 more
wiley   +1 more source

Micro‐QuEChERS Extraction for Broad‐Spectrum LC‐QQQ‐MS Quantification of Nitazene Analogs in Plasma: A Validated Method With Casework Application

Drug Testing and Analysis, EarlyView.
Micro‐QuEChERS sample preparation coupled to LC‐QQQ‐MS enabled sensitive quantification of nitazene analogs in 100 μL of plasma. The validated method provided low detection limits and was successfully applied to an authentic intoxication case involving N‐pyrrolidino protonitazene, supporting clinical and forensic toxicology workflows.
Karla A. O. Souza, Náthaly C. B. F. Santos, Rafael Lanaro, Sara E. Walton, Alex J. Krotulski, Barry K. Logan, Mauricio Yonamine, Jose Luiz Costa   +7 more
wiley   +1 more source

Comportamento de coçar e nocicepção evidenciados após a aplicação facial de endotelina-1: um novo teste, uma nova oportunidade farmacológica [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011O presente trabalho reproduziu o modelo experimental descrito por Shimada e Lamotte, (2008), e o
Gomes, Lenyta Oliveira
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Detection of Nitazenes in the Illicit Drug Supply Utilizing Precursor Ion Scan Methods With Paper Spray Mass Spectrometry

Drug Testing and Analysis, EarlyView.
Nitazenes are increasingly present in the illicit drug supply, complicating harm reduction efforts. We have developed a rapid, nontargeted precursor ion scan method to detect emerging nitazenes in real‐world opioid samples. The method identified multiple nitazenes, often replacing pharmaceutical opioids or mixed with fentanyl and benzodiazepines ...
Allie Miskulin, Irene Shkolnikov, Jindar Sboto, Collin Kielty, Bruce Wallace, Chris G. Gill, Dennis K. Hore   +6 more
wiley   +1 more source

Differential Involvement of μ1-Opioid Receptor on the Antinociception Induced by Dermorphin Tetrapeptide Analogues, Tyr-D-Arg-Phe-β-Ala and Tyr-D-Arg-Phe-β-Ala-NH_2 [PDF]

, 2003
Involvement of μ1-opioid receptor on the antinociception induced by dermorphin tetrapeptide analogues Try-D-Arg-Phe-β-Ala (TAPA) and Tyr-D-Arg-Phe-β-Ala-NH_2 (TAPA-NH_2) were determined in mice, using a tail-pressure test and formalin test. TAPA and TAPA-
ヨネザワ, アキヒコ, 渡邉, 廣行, 林, 貴史, サクラダ, ツカサ, Yuhki, Masayuki, ハヤシ, タカフミ, ユウキ, マサユキ, 溝口, 広一, 米澤, 章彦, Sakurada, Shinobu, Mizoguchi, Hirokazu, サクラダ, シノブ, Watanabe, Hiroyuki, Sakurada, Tsukasa, Yonezawa, Akihiko, ミゾグチ, ヒロカズ, 櫻田, 忍, 櫻田, 誓, Sakurada, Chikai, 結城, 正幸, ワタナベ, ヒロユキ, Hayashi, Takafumi, 櫻田, 司, サクラダ, チカイ   +23 more
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First Occurrence of Fatal Intoxication Involving Methiodone (IC‐26) in Finland; a Medicolegal Autopsy Case Report

Drug Testing and Analysis, EarlyView.
ABSTRACT Methiodone (IC‐26) is a non‐fentanyl novel synthetic opioid which has recently been detected in drug seizures in Europe. There is still limited data about the drug in published toxicological case work, both in non‐fatal and fatal cases. We present a medicolegal autopsy case report on a fatal intoxication in an individual undergoing opioid ...
Lasse Pakanen, Raimo A. Ketola, Pirkko Kriikku   +2 more
wiley   +1 more source

Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor

Nature Communications
The endogenous opioid system provides powerful control over emotions, nociception, and motivation among many other fundamental nervous system functions.
Xiaona Li, Nathan D. Winters, Shubhi Pandey, Colten Lankford, Hannah M. Stoveken, Emery Smith, Chu-Ting Chang, Stefano Zucca, Louis Scampavia, Timothy Spicer, Kirill A. Martemyanov   +10 more
doaj   +1 more source

National opioid pharmacotherapy statistics annual data collection 2012 [PDF]

, 2013
On a snapshot day in 2012, almost 47,000 clients received pharmacotherapy treatment for their opioid dependence at 2,226 dosing points around Australia, this report finds.SummaryAlmost 47,000 Australians received pharmacotherapy treatment for their ...

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GLP‐1 Receptor Agonism Exacerbates Activity‐Based Anorexia in Mice

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Glucagon‐like peptide‐1 receptor (GLP‐1R) agonists reduce food intake and body weight, suggesting they should be avoided in anorexia nervosa. However, preclinical evidence that these drugs reduce activity and reward‐seeking behavior raises the possibility that they might attenuate the compulsive‐like hyperactivity central to ABA ...
Amit Thakar, Travis E. Brown, Shane T. Hentges   +2 more
wiley   +1 more source