Results 161 to 170 of about 139,648 (209)
Some of the next articles are maybe not open access.
2015
The human μ-opioid receptor gene (OPRM1), due to its genetic and structural variation, has been a target of interest in several pharmacogenetic studies. The μ-opioid receptor (MOR), encoded by OPRM1, con- tributes to regulate the analgesic response to pain and also controls the rewarding effects of many drugs of abuse, including opioids, nicotine, and ...
openaire +2 more sources
The human μ-opioid receptor gene (OPRM1), due to its genetic and structural variation, has been a target of interest in several pharmacogenetic studies. The μ-opioid receptor (MOR), encoded by OPRM1, con- tributes to regulate the analgesic response to pain and also controls the rewarding effects of many drugs of abuse, including opioids, nicotine, and ...
openaire +2 more sources
OPIOID RECEPTOR SIGNALLING MECHANISMS
Clinical and Experimental Pharmacology and Physiology, 19991. Three pharmacological types of opioid receptors, μ, δ and κ, and their corresponding genes have been identified. Although other types of opioid receptors have been suggested, their existence has not been established unequivocally. A fourth opioid receptor, ORL1, which is genetically closely related to the others, has also been isolated.
M, Connor, M D, Christie
openaire +2 more sources
The Journal of Steroid Biochemistry and Molecular Biology, 1994
The genomic mode of action is believed to represent the predominant effect of a steroid hormone. Recently, however, rapidly manifesting, non-genomic effects have also been observed. These are mediated mostly by allosteric interaction of a steroid with heterologous target structures such as membrane receptors, a prototype example being the GABAA.
S, Schwarz, P, Pohl
openaire +2 more sources
The genomic mode of action is believed to represent the predominant effect of a steroid hormone. Recently, however, rapidly manifesting, non-genomic effects have also been observed. These are mediated mostly by allosteric interaction of a steroid with heterologous target structures such as membrane receptors, a prototype example being the GABAA.
S, Schwarz, P, Pohl
openaire +2 more sources
2007
AbstractThere are four members of the opioid receptor family mu, delta, kappa and ORL-1. G protein linked receptors. Acute response to ligand binding differs from chronic response. Acute response includes dimerisation, endocytosis and inhibition of adenylyl cyclase, cAMP systems and hyperpolarization of the neuron.
openaire +1 more source
AbstractThere are four members of the opioid receptor family mu, delta, kappa and ORL-1. G protein linked receptors. Acute response to ligand binding differs from chronic response. Acute response includes dimerisation, endocytosis and inhibition of adenylyl cyclase, cAMP systems and hyperpolarization of the neuron.
openaire +1 more source
2002
Abstract Opioid receptors are the targets of analgesic compounds, of which the alkaloid from opium, morphine, remains the most widely used for relieving severe pain. The existence of opioid receptors was first postulated in the 1950s, and established in 1973 by three groups independently (Pert and Snyder 1973; Simon et al .
François Cesselin, Michel Hamon
openaire +1 more source
Abstract Opioid receptors are the targets of analgesic compounds, of which the alkaloid from opium, morphine, remains the most widely used for relieving severe pain. The existence of opioid receptors was first postulated in the 1950s, and established in 1973 by three groups independently (Pert and Snyder 1973; Simon et al .
François Cesselin, Michel Hamon
openaire +1 more source
Historical review: Opioid receptors
Trends in Pharmacological Sciences, 2003A historical review of the early phases of molecular investigations of opioid receptors is presented. The 'modern' era of molecular studies of neurotransmitter and drug receptor research commenced in the 1970s with the identification of receptors using ligand binding techniques. These findings had several ramifications.
Solomon H, Snyder, Gavril W, Pasternak
openaire +2 more sources
Oligomerization of opioid receptors
Methods, 2002Opioid receptors belong to the family of G-protein-coupled receptors characterized by their seven transmembrane domains. The activation of these receptors by agonists such as morphine and endogenous opioid peptides leads to the activation of inhibitory G-proteins followed by a decrease in the levels of intracellular cAMP.
Ivone, Gomes +3 more
openaire +2 more sources
Opioids, Receptors, and Immunity
1993The results achieved by those seeking to determine whether opioids and other drugs of abuse can affect immunity are quite astonishing given the short period of time that research has focused on this area. Despite the fact that there is no longer any question that opioids produce a variety of effects on the immune system, the extent and significance of ...
M W, Adler +4 more
openaire +2 more sources