Results 141 to 150 of about 2,513,925 (427)

Different mechanisms of homologous and heterologous μ‐opioid receptor phosphorylation

British Journal of Pharmacology, 2015
The efficiency of μ‐opioid receptor signalling is tightly regulated and ultimately limited by the coordinated phosphorylation of intracellular serine and threonine residues. Here, we review and discuss recent progress in the generation and application of
Anika Mann, Susann Illing, E. Miess, S. Schulz   +3 more
semanticscholar   +1 more source

Impact of different anesthetic protocols during anesthesia for the establishment of a porcine model of acute kidney injury

Animal Models and Experimental Medicine, EarlyView.
This study details the adaptations required to establish a long‐term anesthetic protocol in pigs. Three protocols were evaluated, with some causing malignant hyperthermia, hypoglycemia, or hemoynamic instability. The final protocol proved effective for developing a porcine AKI model requiring adequate arterial pressure maintenance.
Axel Guilpin, Mathieu Magnin, Axel Aigle, Timothée Schuhler, Jean‐Yves Ayoub, Romain Lac, Charlotte Slek, Thomas Brichart, Abdessalem Hammed, Vanessa Louzier   +9 more
wiley   +1 more source

Rapid isolation and quantification of extracellular vesicles from suspension‐adapted human embryonic kidney cells using capillary‐channeled polymer fiber spin‐down tips

ELECTROPHORESIS, Volume 44, Issue 1-2, Page 190-202, January 2023., 2023
Abstract Exosomes, a subset of extracellular vesicles (EVs, 30–200‐nm diameter), serve as biomolecular snapshots of their cell of origin and vehicles for intercellular communication, playing roles in biological processes, including homeostasis maintenance and immune modulation.
Kaylan K. Jackson, R. Kenneth Marcus
wiley   +1 more source

Molecular Aspects of Opioid Receptors and Opioid Receptor Painkillers

, 2012
The unpleasant sensation of pain is experienced by all human beings at a given point in life. When pain gets severe and/or chronic it requires medical treatment. For over a thousand years, opioid agonists have been employed therapeutically to treat pain, with the first reports of such use involving the alkaloid morphine dated to the second century B.C.(
Austin B. Yongye, Karina Martinez-Mayorga   +1 more
openaire   +4 more sources

Novel GPCR paradigms at the μ‐opioid receptor

British Journal of Pharmacology, 2015
Opioids, such as morphine, are the most clinically useful class of analgesic drugs for the treatment of acute and chronic pain. However, the use of opioids is greatly limited by the development of severe adverse side effects. Consequently, drug discovery
Georgina L. Thompson, E. Kelly, A. Christopoulos, Meritxell Canals   +3 more
semanticscholar   +1 more source

Distinct Alterations of Inflammatory Biomarkers in Cluster Headache: A Case Control Study

Annals of Neurology, EarlyView.
Objective Investigate the immune system's role in cluster headache by analyzing cytokines in people with cluster headache and headache‐free controls, and explore if certain cytokines could predict a specific phenotype. Methods We measured 45 cytokines in adult participants from the Danish Cluster Headache Biobank in a prospective case–control setup ...
Nunu Laura Timotheussen Lund, Connar Stanley James Westgate, Marie‐Louise Kulas Søborg, Agneta Henriette Snoer, Rigmor Højland Jensen, Thomas Folkman Hansen, Anja Sofie Petersen   +6 more
wiley   +1 more source

Effects of kappa-opioid agonist U-50488 and p38 MAPK inhibitor SB203580 on the spike activity of pyramidal neurons in the basolateral amygdala [PDF]

Research Results in Pharmacology 10(1): 1-6 (2024)
Introduction: Kappa-opioid receptor (KOR) signaling in the basolateral amygdala (BLA) underlies KOR agonist-induced aversion. In this study, we aimed to understand the individual and combined effects of KOR agonist U-50488 and p38 MAPK inhibitor SB203580 on the spiking activity of pyramidal neurons in the BLA to shed light on the complex interplay ...
arxiv   +1 more source

CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer [PDF]

, 2008
Opioid agonists have a broad range of effects on cells of the immune system, including modulation of the inflammatory response, and opioid and chemokine receptors are co-expressed by many white cells.
Abbadie, Ayoub, Bahia, Bertini, Bidlack, Bouvier, Brauner-Osborne, Canals, Carrillo, Carrillo, Chen, DeHaven-Hudkins, Dorr, Ellis, Fotiadis, Gao, Geraldine Parenty, Gomes, Graeme Milligan, Grimm, Gupta, Hildebrandt, Hopkins, Horuk, Jacoby, Janecka, Jordan, Jutkiewicz, Lane, Langmead, Levoye, Lopez-Gimenez, May, McVey, Milasta, Milligan, Milligan, Milligan, Milligan, Milligan, Milligan, Milligan, Milligan, Mullaney, Nagano, Neubig, Pascal, Pello, Pol, Ramsay, Rittner, Rogers, Rogers, Salahpour, Shirley Appelbe, Springael, Springael, Suga, Suzuki, Szabo, Trettel, Waldhoer, White, White, Wilson, Wise   +65 more
core   +4 more sources

μ opioid receptor activation hyperpolarizes respiratory‐controlling Kölliker–Fuse neurons and suppresses post‐inspiratory drive

Journal of Physiology, 2015
In addition to reductions in respiratory rate, opioids also cause aspiration and difficulty swallowing, indicating impairment of the upper airways. The Kölliker–Fuse (KF) maintains upper airway patency and a normal respiratory pattern.
E. Levitt, A. Abdala, J. Paton, J. Bissonnette, John T. Williams   +4 more
semanticscholar   +1 more source

Towards Better Opioid Antagonists Using Deep Reinforcement Learning [PDF]

arXiv, 2020
Naloxone, an opioid antagonist, has been widely used to save lives from opioid overdose, a leading cause for death in the opioid epidemic. However, naloxone has short brain retention ability, which limits its therapeutic efficacy. Developing better opioid antagonists is critical in combating the opioid epidemic.Instead of exhaustively searching in a ...
arxiv