Clinical Pharmacology &Therapeutics, EarlyView.Oral medications encounter gut commensal microbes that participate directly and indirectly in drug effects through metabolism, interactions with drug metabolites, or production of substrates that compete with drugs for drug‐metabolizing enzymes, consequently influencing drug pharmacokinetics.
Naomi Gronich +11 more
wiley +1 more source
Characterization of opioid receptors in the cat carotid body involved in chemosensory depression in vivo [PDF]
, 1986 Geoffrey C. Kirby, Daniel S. McQueen
openalex +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan +6 more
wiley +1 more source
Nitrous Oxide Acts Directly at the Mu Opioid Receptor [PDF]
, 1985 Mark A. Gillman, F J Lichtigfeld
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Post‐Mortem Identification and Toxicological Findings of Fluetonitazepyne and Isotonitazepyne
Drug Testing and Analysis, EarlyView.In early 2025, five death cases in Finland tested positive for fluetonitazepyne and one for isotonitazepyne in urine drug screening. A peak corresponding to O‐dealkylated fluetonitazepyne, the 4‐OH‐nitazepyne metabolite, was present in all fluetonitazepyne‐positive urine samples and was later used in the identification of isotonitazepynein one fatal ...
Pirkko Kriikku +3 more
wiley +1 more source
Evaluation of Therapeutic Opioids in Hair of Neonatal and Pediatric Patients
Drug Testing and Analysis, EarlyView.This study investigated the incorporation of novel and traditional medically used opioids into the hair of 118 pediatric and neonatal patients. Concentrations (median [range]) in hair were as follows: fentanyl: 4.03 pg/mg [0.10–343], sufentanil: 0.31 pg/mg [0.10–8.64], remifentanil: 0.14 pg/mg [0.10–0.43], and morphine: 27.4 pg/mg [1.0–1870].
Max Polke +4 more
wiley +1 more source
Paraventricular Nucleus Modulates Excitatory Cardiovascular Reflexes during Electroacupuncture. [PDF]
, 2016 The paraventricular nucleus (PVN) regulates sympathetic outflow and blood pressure. Somatic afferent stimulation activates neurons in the hypothalamic PVN.
Fu, Liang-Wu +3 more
core +1 more source
Clinical and echocardiographic phenotype of cardiac wasting in patients with advanced cancer
European Journal of Heart Failure, EarlyView.Cardiac wasting‐associated cardiomyopathy in cancer patients. E/e', early diastolic filling velocity (E) over mitral annulus early diastolic tissue velocity (e'); GLS, global longitudinal strain; LV, left ventricular; LVEF, left ventricular ejection fraction; TAPSE, tricuspid annular plane systolic excursion.
Markus S. Anker +27 more
wiley +1 more source
The influence of μ-opioid and noradrenaline reuptake inhibition in the modulation of pain responsive neurones in the central amygdala by tapentadol in rats with neuropathy [PDF]
, 2015 Treatments for neuropathic pain are either not fully effective or have problematic side effects. Combinations of drugs are often used. Tapentadol is a newer molecule that produces analgesia in various pain models through two inhibitory mechanisms, namely
Dickenson, AH, Friend, LV, Gonçalves, L
core
Intramolecular Heck Reactions of Cyclic Sulfonamides: Regiochemical Trends and Reductive Cleavage
European Journal of Organic Chemistry, EarlyView.The synthesis of a new class of cyclic sulfonamides and their subsequent conversion into substituted N‐heterocycles is reported. Methyl‐substituted tetrahydropyridine and tetrahydro‐azepine Heck precursors are prepared and cyclized to provide a variety of regioisomeric products.
Hanno Stanley +3 more
wiley +1 more source