Results 201 to 210 of about 86,994 (313)

Modification of amphipathic non-opioid dynorphin A analogues for rat brain bradykinin receptors

, 2014
Yeon Sun Lee, Sara M. Hall, Cyf Ramos‐Colon, Michael Remesic, Lindsay LeBaron, Ann Nguyen, David Rankin, Frank Porreca, Josephine Lai, Victor J. Hruby   +9 more
openalex   +2 more sources

Slow Transit Constipation: Pathophysiological Perspectives and Management Updates

Journal of Digestive Diseases, EarlyView.
Slow transit constipation (STC) is a complex neuromuscular disorder driven by interstitial cells of Cajal (ICCs) loss and enteric neuropathy. Diagnosis relies on objective transit testing while excluding pelvic floor dysfunction. Management follows a stepwise, phenotype‐driven approach, progressing from conventional laxatives to emerging targeted ...
Athanasios Syllaios, Stavros P. Papadakos, Alexandros Ioannou, Maximos Frountzas, Dimosthenis Michelakis, Dimitrios Patsouras, Spyridon Dritsas, Manousos‐Georgios Pramateftakis, Dimitrios Schizas   +8 more
wiley   +1 more source

Single-molecule methods for characterizing receptor dimers reveal metastable opioid receptor homodimers that induce functional modulation. [PDF]

Nat Commun
Zhou P, Tsunoyama TA, Kasai RS, Hirosawa KM, Kalay Z, Aladag A, Fujiwara TK, Yokoyama T, Sakamoto M, Kise R, Yanagawa M, Inoue A, Pigolotti S, Kusumi A.   +13 more
europepmc   +1 more source

Biomarkers of morphine tolerance and dependence are prevented by morphine‐induced endocytosis of a mutant μ‐opioid receptor

, 2009
He Li, Joseph A. Kim, Jennifer L. Whistler   +2 more
openalex   +1 more source

Drug Use After Emergency Department‐Initiated Injectable Buprenorphine: A Secondary Analysis of the ED‐INNOVATION Ancillary Safety and Feasibility Trial

Academic Emergency Medicine, EarlyView.
ABSTRACT Study Objective To characterize opioid and nonopioid drug use in the week following emergency department (ED)‐initiated extended‐release buprenorphine (XR‐BUP) treatment using both self‐reported data and urine drug screens (UDS). Methods This study uses data collected during a nonrandomized clinical trial of patients with untreated opioid use ...
Ethan Cowan, Gail D'Onofrio, Jeanmarie Perrone, Erik Anderson, James Dziura, Kathryn Hawk, Andrew Herring, Ryan McCormack, Manali Phadke, Elizabeth A. Samuels, David A. Fiellin   +10 more
wiley   +1 more source

Single-molecule characterization of opioid receptor heterodimers reveals soluble µ-δ dimer blocker peptide alleviates morphine tolerance. [PDF]

Nat Commun
Zhou P, Kasai RS, Fujita W, Tsunoyama TA, Neyama H, Ueda H, Yokoyama T, Sakamoto M, Pigolotti S, Fujiwara TK, Kusumi A.   +10 more
europepmc   +1 more source

Effect of insulin on the antinociceptive effect of μ-and δ-opioid receptor agonists in mice

, 1998
Midori Sodeyama, Masahiro Ohsawa, Hiroshi Nagase, Junzo Kamei   +3 more
openalex   +1 more source

Trajectories of medication for opioid use disorder and their impact on HIV testing among people who inject drugs in India: A longitudinal assessment of clinic‐based data

Addiction, Volume 120, Issue 4, Page 745-755, April 2025.
Abstract Aims The aim of this study was to identify longitudinal trajectories of medication for opioid use disorder (MOUD) use throughout 1 year following MOUD initiation and to examine the association of trajectory membership with HIV testing among people who inject drugs in India.
Allison M. McFall, Lakshmi Ganapathi, Mihili P. Gunaratne, Aylur K. Srikrishnan, Conjeevaram K. Vasudevan, Santhanam Anand, Sunil S. Solomon, Shruti H. Mehta, Gregory M. Lucas   +8 more
wiley   +1 more source

Toward Predictive Models of Biased Agonists of the Mu Opioid Receptor. [PDF]

Biochemistry
Tun-Rosado FJ, Abreu-Martínez EE, Magdaleno-Rodriguez A, Martinez-Mayorga K.   +3 more
europepmc   +1 more source

Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review

Addiction, EarlyView.
Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper, Francesca Small, Sam Brown, Michael Kelleher, Luke Mitcheson, James Rucker, Allan H. Young, John Marsden   +7 more
wiley   +1 more source