Results 201 to 210 of about 2,513,925 (427)

Detection of Opioid Users from Reddit Posts via an Attention-based Bidirectional Recurrent Neural Network [PDF]

The opioid epidemic, referring to the growing hospitalizations and deaths because of overdose of opioid usage and addiction, has become a severe health problem in the United States. Many strategies have been developed by the federal and local governments and health communities to combat this crisis.
arxiv   +1 more source

In-vivo studies on kappa opioid receptors [PDF]

, 1986
Alan Cowan, Debra E. Gmerek
openalex   +1 more source

Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands

ChemMedChem, EarlyView.
This study highlights the tetrahydropyrrolo[3,4‐c]pyrazole scaffold as a promising platform for S1R ligands development. Key findings include compound 19’s high S1R affinity (Ki=75 nM), influenced by strategic nitrogen substitutions and reduced steric hindrance.
Giuseppe Cosentino, Maria Dichiara, Giuliana Costanzo, Alessandro Coco, Lorella Pasquinucci, Agostino Marrazzo, Antonio Rescifina, Emanuele Amata   +7 more
wiley   +1 more source

Anatomical relationship between opioid peptides and receptors in rhesus monkey brain [PDF]

, 1984
Michael E. Lewis, Henry Khachaturian, Huda Akil, Stanley J. Watson   +3 more
openalex   +1 more source

Further SAR of GIRK1/2 activators: Synthesis and Biological Characterization of In Vitro Tool Compounds

ChemMedChem, Accepted Article.
The work presented herein outlines the ongoing structure‐activity relationship (SAR) studies centered around a potent, efficacious, and selective activators of the GIRK1/2 channel. Optimization studies centered around the pyrazole privileged scaffold, the N‐1‐position of the pyrazole and the right‐hand ether.
Sumaiya Nahid, Fahad Imtiaz Rahman, Yu Du, Brittany Spitznagel, Sandeep K Singh, Yashpal Chhonker, Daryl J Murry, David Weaver, Corey R Hopkins   +8 more
wiley   +1 more source

Advancing access to Medicare‐funded mental health treatment during the opioid epidemic: A counselor advocacy analysis

Journal of Counseling &Development, Volume 101, Issue 1, Page 15-28, January 2023., 2023
Abstract Although advocacy is a priority for counseling professionals, little is known about counseling advocates’ participation in the legislative advocacy process. Recent legislation to address the opioid crisis allowed counseling advocates to provide public comments to advance counselor inclusion in the Medicare program.
Jordan B. Westcott, Matthew C. Fullen, Justin Jordan   +2 more
wiley   +1 more source

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. [PDF]

, 2018
The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects.
Livingston, Kathryn E, Mahoney, Jacob P, Manglik, Aashish, Sunahara, Roger K, Traynor, John R   +4 more
core  

Acute systemic administration of morphine selectively increases mu opioid receptor binding in the rat brain [PDF]

, 1984
James W. Lewis, Michael E. Lewis, Deborah J. Loomus, Huda Akil   +3 more
openalex   +1 more source

High‐Throughput Drug Derivatization and Bioassay by Desorption Electrospray Ionization Mass Spectrometry

ChemPlusChem, Accepted Article.
Adapting high‐throughput (HT) synthetic methods to the modification of drugs and to testing of their bioactivity should expedite drug discovery. Here, we demonstrate the applicability of HT desorption electrospray ionization mass spectrometry (DESI MS) to achieve late‐stage functionalization (LSF) and so to rapidly generate a modified opioid library ...
R Graham Cooks, Jyotirmoy Ghosh, Nicolás M. Morato, Yunfei Feng   +3 more
wiley   +1 more source

Treatment barriers and gender‐based perceptions: Establishing gender‐based treatment specialty facilities as a strategy to motivate South African young women to seek treatment for substance use disorders

Journal of Community Psychology, Volume 51, Issue 1, Page 182-200, January 2023., 2023
Abstract South Africa alongside other low‐middle‐income countries have been some of the hardest hit by the substance use scourge. The study sought to identify and measure treatment barriers among young adults (18–29 years) living with substance use disorders, and then examine the role of gender in the perception of treatment barriers, with a view to ...
Tichaenzana Nyashanu, Herbert Zirima
wiley   +1 more source