Results 211 to 220 of about 87,734 (315)

Autonomic nervous system modulation by G protein-biased mu-opioid receptor agonists: A translational scoping review protocol. [PDF]

PLoS One
Zhang Y, Chen Q, Zhou Y, Zeng Q, Cui H, Zhou Y.   +5 more
europepmc   +1 more source

Impact of Institutional Protocol on Urinary Catheter Outcome Measures in Orthopedic Children Treated With Epidural Analgesia

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Epidural analgesia is commonly used for pain control after major lower‐limb orthopedic surgery in children, but it is associated with a risk of postoperative urinary retention. Consequently, urinary catheters are often placed and left in situ for the full duration of epidural analgesia, despite the potential risks of prolonged ...
Idan Katz, Tomer Talmy, Dor Barami, Tal S. Beckmann, Barry Danino, Yotam Lior, Margaret Ekstein   +6 more
wiley   +1 more source

Mapping partial agonism of mitragynine at the µ-opioid receptor through molecular dynamics and Markov state modelling analysis. [PDF]

Sci Rep
Bahari MNA, Azmi L, Fei LC, Syahir A, Perimal E, Manaf AA, Jamali MAM.   +6 more
europepmc   +1 more source

Codeine and Metabolite Concentrations in the Breastfed Neonate

Pediatric Anesthesia, EarlyView.
ABSTRACT Analgesic effect from codeine is from its metabolite, morphine. Morphine is formed by the O‐demethylation of codeine and that enzyme is controlled by the cytochrome P450 2D6. More than 60 alleles in the CYP2D6 gene have been identified. This spectrum of polymorphism can be categorized into four groups: poor (PM), intermediate (IM), normal (NM),
Brian J. Anderson, Jacqueline A. Hannam
wiley   +1 more source

Kappa opioid receptor control of motivated behavior revisited. [PDF]

Neuropsychopharmacology
Farahbakhsh ZZ, Siciliano CA.
europepmc   +1 more source

Plasma Lidocaine Concentrations During Intravenous Lidocaine Infusion Therapy in the Pediatric Population—A Scoping Review

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Intravenous lidocaine therapy (IVLT) is often used in perioperative multimodal analgesia due to its analgesic, anti‐hyperalgesic, and anti‐inflammatory effects. In adults, IVLT doses of 1–2 mg/kg/h produce plasma concentrations of 1–2 μg/mL, within the presumed therapeutic range of 1–5 μg/mL.
McKenna Postles, Amanda Barton, Nicholas West, Gillian Lauder   +3 more
wiley   +1 more source

G protein regulatory network shapes magnitude and kinetics of behavioral responses in an engineered opioid receptor model. [PDF]

J Biol Chem
Coleman DL, Ren RJ, Opperman KJ, Kwan EX, Martemyanov KA, Grill B.   +5 more
europepmc   +1 more source

Peptidomics and pharmacological profiling of Odontobuthus doriae (Buthidae) scorpion venom at the kappa opioid receptor. [PDF]

Sci Rep
Abdollahnia A, Bata BB, Fraunhofer A, Hermes J, Atashi J, Ghassempour A, Gruber CW.   +6 more
europepmc   +1 more source

Processed EEG Monitoring During Pediatric Procedural Sedation: Correlation Between the Narcotrend Index and the Pediatric Sedation State Scale

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Objective assessment of sedation depth in children undergoing procedural sedation while maintaining spontaneous breathing and protective reflexes can be challenging. Processed electroencephalogram (pEEG) monitoring systems such as the Narcotrend monitor may provide continuous information regarding the depth of sedation.
Hendryk Schneider, Daniel Matheisl, Martin Kuntz, Hans Fuchs   +3 more
wiley   +1 more source

The molecular basis of μ-opioid receptor signaling plasticity. [PDF]

Cell Res
Zhang H, Wang X, Xi K, Shen Q, Xue J, Zhu Y, Zang SK, Yu T, Shen DD, Guo J, Chen LN, Ji SY, Qin J, Dong Y, Zhao M, Yang M, Wu H, Yang G, Zhang Y.   +18 more
europepmc   +1 more source