Results 231 to 240 of about 1,391,378 (297)

Median Effective Volume of 0.2% Ropivacaine for Ultrasound‐Guided Axillary Brachial Plexus Block in Children Aged 6–10 Years: A Prospective Dose‐Finding Study Using Up‐and‐Down Sequential Allocation

Pediatric Discovery, EarlyView.
Purpose: This study aimed to determine the median effective volume (EV50) of 0.2% ropivacaine for ultrasound‐guided axillary brachial plexus block (ABPB) in children aged 6–10 years, using the Dixon up‐and‐down method. The EV50 was 0.350 mL/kg (95% CI: 0.197–0.362 mL/kg), calculated by isotonic regression and bootstrapping.
Tauseef Ahmad, Fei Yang, Yao Xu, Ying Yang, Huanjie Yun, Fei Xu, Yulin Xue, Yu Zhou, Zongke Shi, Yuan Shi, Shangyingying Li, Shengfen Tu   +11 more
wiley   +1 more source

Core stability in women with and without chronic pelvic pain

PM&R, EarlyView.
Abstract Background Physical activity (PA) and core stability levels are unknown for women with musculoskeletal chronic pelvic pain (CPP) compared to healthy women. At this time, there is no validated treatment method aimed specifically at CPP. Objective To elucidate the PA habits and core stability of women with and without CPP.
Hannah V. Chatwin, Abhilasha Kumar, Michael Wesolowski, Laura Glaser, Colleen M. Fitzgerald, Stacey Bennis   +5 more
wiley   +1 more source

Hypovitaminosis D in acute inpatient cancer rehabilitation: Prevalence, predictors, and practical implications

PM&R, EarlyView.
Abstract Background Hypovitaminosis D is associated with adverse health outcomes, including increased mortality in patients with cancer. Although vitamin D insufficiency (23%–72%) and deficiency (20%–71%) are common among patients admitted to inpatient rehabilitation, their prevalence and predictors in cancer‐specific inpatient rehabilitation ...
Jegy M. Tennison, Minxing Chen, Areeba Hafeez, Ananya Krishnan, Sefia Khan, Rony Dev, Sonal Admane, Eduardo Bruera   +7 more
wiley   +1 more source

Mapping partial agonism of mitragynine at the µ-opioid receptor through molecular dynamics and Markov state modelling analysis. [PDF]

Sci Rep
Bahari MNA, Azmi L, Fei LC, Syahir A, Perimal E, Manaf AA, Jamali MAM.   +6 more
europepmc   +1 more source

An engineered nanobody inhibitor for molecular-to-circuit control of opioid receptor function

Valbret Z, Lamothe-Molina PJ, Papadogkonaki S, Koehl A, Arafiles JVV, Shapiro Tuchman Z, Fisher NM, Radoux-Mergault A, Canziani A, Huang G, von Zastrow M, Kosloff M, Hackenberger CPR, Manglik A, Patriarchi T, Stoeber M.   +15 more
europepmc   +1 more source

Delta Opioid Receptors and Cardioprotection

, 2017
The opioid receptor family, with associated endogenous ligands, has numerous roles throughout the body. Moreover, the delta opioid receptor (DORs) has various integrated roles within the physiological systems, including the cardiovascular system.
Hoe, Louise See, Patel, Hemal H, Peart, Jason N   +2 more
openaire   +6 more sources

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Opioid Receptors

Annual Review of Biochemistry, 2004
▪ Abstract  Opioid receptors belong to the large superfamily of seven transmembrane-spanning (7TM) G protein-coupled receptors (GPCRs). As a class, GPCRs are of fundamental physiological importance mediating the actions of the majority of known neurotransmitters and hormones. Opioid receptors are particularly intriguing members of this receptor family.
Waldhoer, Maria, Bartlett, Selena E., Whistler, Jennifer L.   +2 more
openaire   +3 more sources

Opioid Receptors and their Ligands

Current Topics in Medicinal Chemistry, 2004
This review gives a historical perspective, summarizing approximately 25 years of research on opioids. The "typical" opioid peptides produced in the brain, "atypical" opioids encrypted in milk protein or hemoglobin sequences, and extremely potent and selective opioids of amphibian origin are described.
Anna, Janecka, Jakub, Fichna, Tomasz, Janecki   +2 more
openaire   +2 more sources

Opioid receptor polymorphismsand opioid abuse

Pharmacogenomics, 2002
The sequencing of the human genome is only the first step. The next step is to determine the function of these genes and in particular, how alterations in specific genes lead to major human disorders. Many laboratories are now focusing on identifying and characterizing single nucleotide polymorphisms (SNPs), to determine which correlate in frequency ...
Nancy M, Lee, Andrew P, Smith
openaire   +2 more sources