Perioperative Opioid Use and Risk of Persistent Use After Common Otolaryngologic Procedures
Abstract Objective The objective of this study was to evaluate the incidence of perioperative opioid prescription and the development of new persistent opioid usage in patients prescribed perioperative opioids for common otolaryngological procedures. Study Design Retrospective cohort study. Setting TriNetX US Collaborative Research Network. Methods The
Michael Liu +3 more
wiley +1 more source
Rational design of a Kappa opioid receptor peptide agonist with attenuated β-arrestin signaling. [PDF]
Zhang H +20 more
europepmc +1 more source
Mental Health Risk Factors for Postoperative Pain in Head and Neck Free Flap Reconstruction Patients
Abstract Objective Head and neck cancer (HNC) surgery is associated with postoperative pain and comorbid mental health disorders (MHDs). This study assessed predictors of postoperative pain and inpatient pain service consultation following free flap reconstruction (FFR). Study Design Retrospective cohort. Setting Single‐institution database.
Daniel R. S. Habib +8 more
wiley +1 more source
Functional significance of opioid receptor homomers and heteromers. [PDF]
Ferré S, Ciruela F, Pardo L.
europepmc +1 more source
Association Between Postoperative NSAID Use and Bleeding Following Transoral Robotic Surgery
Abstract Objective To evaluate the safety and outcomes of NSAID use following transoral robotic surgery (TORS). Study Design Retrospective cohort study using propensity score matching. Setting Multi‐institutional database (TriNetX). Methods Patients undergoing TORS were identified using ICD‐10 codes.
Brayden Seliger +6 more
wiley +1 more source
Evidence that xylazine disrupts skin homeostasis by acting on epithelial cells through the kappa opioid receptor. [PDF]
Robertson TF +3 more
europepmc +1 more source
Nonpharmacologic Therapy for Pediatric Posttonsillectomy Pain: A Systematic Review
Abstract Objective To understand efficacies of nonpharmacologic therapy for pediatric posttonsillectomy pain. Data Sources CINAHL, Cochrane Library, PubMed, and Scopus. Review Methods Studies on nonpharmacologic interventions for pediatric posttonsillectomy pain were included in this systematic review.
Justina T. Sargios +5 more
wiley +1 more source
Structure-Guided Repurposing of Approved Drugs Identifies Aprepitant and Mavorixafor as Putative δ-Opioid Receptor Agonist Candidates. [PDF]
Buccheri R +5 more
europepmc +1 more source
Error Traps in Pediatric Neuromuscular Block
ABSTRACT Background Neuromuscular blocking agents are essential for safe pediatric anesthesia but remain a frequent source of preventable morbidity when misused, inadequately monitored, or incompletely reversed. Children, particularly neonates and infants, are especially vulnerable to residual neuromuscular block due to developmental pharmacological ...
Gabriel Soares de Sousa +5 more
wiley +1 more source

