ABSTRACT In the 1980s, researchers discovered the remarkable ability of electrospray plumes to effectively ionize gas‐phase molecules via secondary ionization. Around 20 years later—coinciding with the ambient mass spectrometry revolution—secondary electrospray ionization (SESI) and extractive electrospray ionization (EESI) coupled to mass spectrometry
Xin Luo +5 more
wiley +1 more source
Structure-guided design of partial agonists at an opioid receptor. [PDF]
Varga BR +20 more
europepmc +1 more source
Different mechanisms of homologous and heterologous μ‐opioid receptor phosphorylation
Anika Mann +3 more
semanticscholar +1 more source
Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.
Hyesik Kong +5 more
openalex +1 more source
Intratumoral Nerve Phased Development: A Promising Therapeutic Target
ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che +3 more
wiley +1 more source
Molecular and cellular basis of mu-opioid receptor signaling: mechanisms underlying tolerance and dependence development. [PDF]
Swingler M +4 more
europepmc +1 more source
Novel GPCR paradigms at the μ‐opioid receptor
Georgina L. Thompson +3 more
semanticscholar +1 more source
Distinction and mutual Influences between Parkinson's Disease‐related and unrelated Chronic Pain
Abstract Background Chronic pain (i.e. > 3 months) is a common nonmotor symptom in patients with Parkinson's disease (PD), but the attribution to PD is critical for further treatment. Objectives We explored the PD Pain Classification System (PD‐PCS) criteria for the diagnosis of PD‐related pain and mutual influences between PD‐related and PD‐unrelated ...
Jonathan Hunger +11 more
wiley +1 more source
Evidencing the role of a conserved polar signaling channel in the activation mechanism of the μ-opioid receptor. [PDF]
Sarkar A +6 more
europepmc +1 more source
The Effects of NMDA Receptor Antagonists and Nitric Oxide Synthase Inhibitors on Opioid Tolerance and Withdrawal Medication Development Issues for Opiate Addiction [PDF]
Barry K. Herman
openalex +1 more source

