Results 281 to 290 of about 2,513,925 (427)

Estimating the Cost and Carbon Output of Musculoskeletal Primary Care Management Decisions: A Retrospective Analysis of Electronic Health Records

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Background Healthcare accounts for up to 5% of worldwide carbon emissions and costs global economies an estimated $9 trillion annually. Primary care accounts for up to one‐fifth of all NHS carbon emissions, with musculoskeletal (MSK) pain accounting for 14%–30% of all primary care consultations.
Alex Braybrooke, Melissa Pegg, Rebecca Naylor, James Bailey, James Scott, Roanna Burgess, Dahai Yu, Simon Wathall, Kelvin P. Jordan, Robert Malcolm, Hayden Holmes, George Peat, Anirban Banerjee, Jonathan C. Hill   +13 more
wiley   +1 more source

Central monitoring of depression and anxiety symptoms reduces placebo responses in depression clinical trials: A post hoc exploratory analysis of data from the phase III CCT‐004 trial of vortioxetine

Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 468-477, December 2022., 2022
Abstract Aim Clinical trials of antidepressants often fail to demonstrate their efficacy versus placebo, suggesting that patient selection based on physician ratings of depression may contribute to a high placebo response. Methods In the CCT‐004 trial of vortioxetine, central monitoring was employed to compare physician and patient ratings of ...
Yoshinori Watanabe, Akira Nishimura, Toshiaki Kikuchi, Norifusa Sawada, Manami Imazaki, Isao Inada, Koichiro Watanabe   +6 more
wiley   +1 more source

Peripheral opioid receptor antagonism alleviates fentanyl-induced cardiorespiratory depression and is devoid of aversive behavior. [PDF]

Elife
Ruyle BC, Masud S, Kesaraju R, Tahirkheli M, Modh J, Roth CG, Angulo-Lopera S, Lintz T, Higginbotham JA, Massaly N, Morón JA.   +10 more
europepmc   +1 more source

Intrathecal Pertussis Toxin Treatment Attenuates Opioid Antinociception and Reduces High-affinity State of Opioid Receptors [PDF]

, 1992
Chih‐Shung Wong, Ying-Fu Su, Kwen‐Jen Chang, W. David Watkins   +3 more
openalex   +1 more source

Propagation of conformational changes during μ-opioid receptor activation

Nature, 2015
Rémy Sounier, Camille Mas, J. Steyaert, T. Laeremans, A. Manglik, Weijiao Huang, B. Kobilka, H. Déméné, S. Granier   +8 more
semanticscholar   +1 more source

The Utility of Cyclodextrin for Countering μ-Opioid Receptor Drug Overdoses. [PDF]

ACS Cent Sci
Ogawa N.
europepmc   +1 more source

Inhibitory Effects of NaCl and Guanyl-5'yl-imidodiphosphate (GppNHp) on (3H)Naloxone Binding to .KAPPA.-Opioid Receptors in Guinea Pig Cerebellum.

, 1993
Kumiko Ishige, M Makimura, Yukako Ιtο, Y. Murakoshi   +3 more
openalex   +2 more sources

Research progress on the mechanisms of pain empathy

Ibrain, EarlyView.
This article is related to the graphical research progress of pain empathy, starting with the description of the pain matrix and mirror neurons. Based on the pain matrix and mirror neurons, pain empathy results from the combined action of brain regions such as the anterior cingulate cortex, insula, prefrontal cortex, and amygdala and regulatory ...
Shuangshuang Liu, Siwei Wang, Yan Yan, Bangyong Qin, Qingxiang Mao, Jie Yuan   +5 more
wiley   +1 more source

Reversal of Diabetic Dry Eye by Topical Opioid Receptor Blockade Follows Dual Pathways. [PDF]

Invest Ophthalmol Vis Sci
Diaz D, Sassani JW, Zagon IS, McLaughlin PJ.   +3 more
europepmc   +1 more source

Cesarean section: One procedure, varied techniques. Detailed observations of 1013 first cesarean sections in a tertiary hospital in Ghana

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Cesarean sections (CS) are among the most performed surgical procedures in the world. Small variations in surgical techniques could have a significant impact on a global scale, for example, in postoperative complications. In the present study we aimed to observe and audit every single step used during first time CS.
Kwaku Asah‐Opoku, Tessa Heesterman, Mona Lu Zeevaert, Kofi Agyabeng, Joyce L. Browne, Nelson Damale, Rick Grobbee, Mercy A. Nuamah, Kitty W. M. Bloemenkamp, Marcus J. Rijken   +9 more
wiley   +1 more source