Results 281 to 290 of about 2,594,817 (409)

Predicting Pharmacological Treatment Response in Migraine Using AI/ML: A Scoping Review of the Evidence and Future Directions

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
ABSTRACT The treatment of migraine is hampered by inter‐individual variability, leading to an inefficient “trial and error” approach. Artificial intelligence (AI) and machine learning (ML) offer a path towards precision medicine by predicting therapeutic outcomes.
Martina Giacon, Salvatore Terrazzino
wiley   +1 more source

Mu-opioid receptor activation potentiates excitatory transmission at the habenulo-peduncular synapse. [PDF]

Cell Rep
Singhal SM, Szlaga A, Chen YC, Conrad WS, Hnasko TS.   +4 more
europepmc   +1 more source

Frozen in Addiction: A New Wave of Drug‐Induced Movement Disorders?

Movement Disorders, EarlyView.
Christos Ganos, Roberto Erro, Mohammad Abdullah, Tanya S. Hauck, Daniel Ciccarone, Christy Sutherland, Parisa Saiyarsarai, Connie Marras, Susan H. Fox, Alfonso Fasano, Anthony E. Lang, Jonathan Squires, Kailash P. Bhatia   +12 more
wiley   +1 more source

Opioid consumption after lower limb amputation in Medicare beneficiaries

PM&R, EarlyView.
Abstract Background Despite targeted national quality improvement initiatives, opioid prescription and use patterns after lower limb amputation are not well studied. Objective To determine risk factors associated with extended opioid use and rates of high‐risk opioid prescribing after lower limb amputation. Design and setting A retrospective population‐
Alexander N. Khouri, Nishant Ganesh Kumar, Hsou‐Mei Hu, Maryam Yazdanfar, Jennifer F. Waljee, Theodore A. Kung   +5 more
wiley   +1 more source

Structure-guided design of partial agonists at an opioid receptor. [PDF]

Nat Commun
Varga BR, Bernhard SM, El Daibani A, Zaidi SA, Lam JH, Aguilar J, Appourchaux K, Nazarova AL, Kouvelis A, Shinouchi R, Hammond HR, Eans SO, Weinreb V, Margolis EB, Fay JF, Huang XP, Pradhan A, Katritch V, McLaughlin JP, Majumdar S, Che T.   +20 more
europepmc   +1 more source

Mu-opioid receptor single nucleotide polymorphisms in the third intracellular loop affect receptor signalling in a pathway specific manner

, 2018
Marina Santiago, Alisa Knapman, Mark Connor   +2 more
openalex   +2 more sources

Cebranopadol: A Novel Potent Analgesic Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist

Journal of Pharmacology and Experimental Therapeutics, 2014
K. Linz, T. Christoph, T. Tzschentke, T. Koch, K. Schiene, M. Gautrois, W. Schröder, B. Kögel, H. Beier, W. Englberger, S. Schunk, J. de Vry, U. Jahnel, S. Frosch   +13 more
semanticscholar   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Molecular and cellular basis of mu-opioid receptor signaling: mechanisms underlying tolerance and dependence development. [PDF]

Front Neurosci
Swingler M, Donadoni M, Unterwald EM, Maggirwar SB, Sariyer IK.   +4 more
europepmc   +1 more source

Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia.

Journal of Clinical Investigation, 2014
Ji-Tian Xu, Jian-Yuan Zhao, Xiuli Zhao, Davinna L. Ligons, V. Tiwari, Fidelis E. Atianjoh, Chun-Yi Lee, Lingli Liang, Weidong Zang, D. Njoku, S. Raja, M. Yaster, Y. Tao   +12 more
semanticscholar   +1 more source