Results 31 to 40 of about 2,542,870 (405)
Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]
, 2013 There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Ammer, Hermann +2 more
core +2 more sources
Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists
Science Advances, 2019 Crystal structures provide first atomic-level insights into δ-opioid receptor activation by two structurally diverse agonists. Selective activation of the δ-opioid receptor (DOP) has great potential for the treatment of chronic pain, benefitting from ...
T. Claff +18 more
semanticscholar +1 more source
Untangling the complexity of opioid receptor function
Neuropsychopharmacology, 2018 Mu opioid receptor agonists are among the most powerful analgesic medications but also among the most addictive. The current opioid crisis has energized a quest to develop opioid analgesics that are devoid of untoward effects.
R. Valentino, N. Volkow
semanticscholar +1 more source
BJA Open, 2023 Opioids are a mainstay in acute pain management and produce their effects and side effects (e.g., tolerance, opioid-use disorder and immune suppression) by interaction with opioid receptors.
David G. Lambert
doaj
Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice
Haematologica, 2015 Treatment of pain with morphine and its congeners in sickle cell anemia is suboptimal, warranting the need for analgesics devoid of side effects, addiction and tolerance liability. Small-molecule nociceptin opioid receptor ligands show analgesic efficacy
Derek Vang +7 more
doaj +1 more source
Pharmacology Research & Perspectives, 2022 Morphine is frequently applied in cancer patients for pain management. However, its effects on cancer are not well understood but observed to be specific to certain cancer types. We previously revealed the stimulatory properties of morphine in esophageal
Zhengwen Yu +3 more
doaj +1 more source
Life, 2021 Cross-talk between opioid and adrenergic receptors is well-characterized and involves second messenger systems, the formation of receptor heterodimers, and the presence of extracellular allosteric binding regions for the complementary ligand; however ...
Robert Root-Bernstein, Beth Churchill
doaj +1 more source
Specific down-regulation of spinal μ-opioid receptor and reduced analgesic effects of morphine in mice with postherpetic pain [PDF]
, 2006 The analgesic effects of opioid agonists and the expression of μ-and κ-opioid receptors were compared between mice with herpetic pain and those with postherpetic pain induced by herpetic virus inoculation.
Kuraishi Yasushi +3 more
core +2 more sources
British Journal of Pharmacology, 2018 PZM21 is a novel μ‐opioid receptor ligand that has been reported to induce minimal arrestin recruitment and be devoid of the respiratory depressant effects characteristic of classical μ receptor ligands such as morphine.
R. Hill +8 more
semanticscholar +1 more source
Morphine activates neuroinflammation in a manner parallel to endotoxin [PDF]
, 2012 Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors.
A. A. Somogyi +42 more
core +2 more sources