The Potential of Methocinnamox as a Future Treatment for Opioid Use Disorder: A Narrative Review
Pharmacy, 2022 The opioid epidemic is an ongoing public health crisis, and the United States health system is overwhelmed with increasing numbers of opioid-related overdoses.
Colleen G. Jordan +5 more
doaj +1 more source
Binding mode analyses of NAP derivatives as mu opioid receptor selective ligands through docking studies and molecular dynamics simulation [PDF]
, 2017 Mu opioid receptor selective antagonists are highly desirable because of their utility as pharmacological probes for receptor characterization and functional studies.
Wang, Huiqun +2 more
core +2 more sources
Untangling the complexity of opioid receptor function
Neuropsychopharmacology, 2018 Mu opioid receptor agonists are among the most powerful analgesic medications but also among the most addictive. The current opioid crisis has energized a quest to develop opioid analgesics that are devoid of untoward effects.
R. Valentino, N. Volkow
semanticscholar +1 more source
Morphine activates neuroinflammation in a manner parallel to endotoxin [PDF]
, 2012 Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors.
A. A. Somogyi +42 more
core +2 more sources
Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice
Haematologica, 2015 Treatment of pain with morphine and its congeners in sickle cell anemia is suboptimal, warranting the need for analgesics devoid of side effects, addiction and tolerance liability. Small-molecule nociceptin opioid receptor ligands show analgesic efficacy
Derek Vang +7 more
doaj +1 more source
Specific down-regulation of spinal μ-opioid receptor and reduced analgesic effects of morphine in mice with postherpetic pain [PDF]
, 2006 The analgesic effects of opioid agonists and the expression of μ-and κ-opioid receptors were compared between mice with herpetic pain and those with postherpetic pain induced by herpetic virus inoculation.
Kuraishi Yasushi +3 more
core +2 more sources
Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists
Science Advances, 2019 Crystal structures provide first atomic-level insights into δ-opioid receptor activation by two structurally diverse agonists. Selective activation of the δ-opioid receptor (DOP) has great potential for the treatment of chronic pain, benefitting from ...
T. Claff +18 more
semanticscholar +1 more source
Modulation of Neurally Mediated Vasodepression and Bradycardia by Electroacupuncture through Opioids in Nucleus Tractus Solitarius. [PDF]
, 2018 Stimulation of vagal afferent endings with intravenous phenylbiguanide (PBG) causes both bradycardia and vasodepression, simulating neurally mediated syncope.
Fu, Liang-Wu +3 more
core +3 more sources
British Journal of Pharmacology, 2018 PZM21 is a novel μ‐opioid receptor ligand that has been reported to induce minimal arrestin recruitment and be devoid of the respiratory depressant effects characteristic of classical μ receptor ligands such as morphine.
R. Hill +8 more
semanticscholar +1 more source