Selective up‐regulation of functional mu‐opioid receptor splice variants by chronic opioids [PDF]
, 2015 Sumita Chakrabarti +2 more
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British Journal of Clinical Pharmacology, EarlyView.Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko +9 more
wiley +1 more source
Activation of the μ‐opioid receptor by alicyclic fentanyls: Changes from high potency full agonists to low potency partial agonists with increasing alicyclic substructure [PDF]
, 2020 Anna Åstrand +5 more
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Contemporary and Emerging Therapies in the Management of Refractory Angina: A Clinical Review
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Refractory angina (RA) represents a growing challenge in clinical cardiology, particularly in patients with obstructive coronary artery disease (CAD) who remain symptomatic despite optimal medical therapy and who are not candidates for revascularization.
Alex Angers‐Goulet +4 more
wiley +1 more source
Role of Mu-Opioid Receptor in Nociceptive Modulation in the Anterior Cingulate Cortex of Rats with Inflammatory Pain [PDF]
, 2019 Wang Ll, Hou KS, HB Wang, Fu FH, Yu Lc
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Effects of N-Substituents on the Functional Activities of Naltrindole Derivatives for the δ Opioid Receptor: Synthesis and Evaluation of Sulfonamide Derivatives [PDF]
, 2020 Chiharu Iwamatsu +7 more
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ChemistryEurope, EarlyView.This review highlights the powerful synergy between mechanochemistry and solid reagents to replace hazardous substances traditionally used in organic synthesis. Such an approach offers a safer and more sustainable pathway for conducting organic reactions, with potential benefits in both reactivity and selectivity. The use of solid bases, acids, and gas
Adrien Gallego +4 more
wiley +1 more source
Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview
Chemistry – A European Journal, EarlyView.The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati +4 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.MDMB‐5Br‐PINACA, a novel synthetic cannabinoid, was identified and structurally characterized in seized herbal products using GC‐MS, LC‐HRMS, and NMR. The discovery underscores ongoing diversification of SCs and the need for vigilant surveillance.
Alexandre Barcia de Godoi +6 more
wiley +1 more source
Clinical and echocardiographic phenotype of cardiac wasting in patients with advanced cancer
European Journal of Heart Failure, EarlyView.Cardiac wasting‐associated cardiomyopathy in cancer patients. E/e', early diastolic filling velocity (E) over mitral annulus early diastolic tissue velocity (e'); GLS, global longitudinal strain; LV, left ventricular; LVEF, left ventricular ejection fraction; TAPSE, tricuspid annular plane systolic excursion.
Markus S. Anker +27 more
wiley +1 more source