Results 161 to 170 of about 2,447,948 (384)

The Hippocampus Is the Place to Be: Opioid Receptors and LTP

open access: yesCell Reports, 2019
Nam et al. (2019) genetically modulate the expression of astrocytic μ-opioid receptors to reveal they are necessary for drug-induced conditioned place preference.
Thomas M. Sanderson   +3 more
doaj  

Dose Determinations at Drug Approval Reviews: FDA‐Approved Drugs in Past 5 Years

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Drug dose appropriateness is one of the most discussed issues in regulatory reviews. We analyzed dose determinations during Food and Drug Administration (FDA) drug reviews to determine whether there were changes between the proposed and approved doses of new molecular entities (NMEs), including cases where postmarketing dose‐finding studies were ...
Sachiko Mita, Shunsuke Ono
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

open access: yes, 2022
Hepatology, EarlyView.
Robert J. Fontana   +6 more
wiley   +1 more source

Treatment barriers and gender‐based perceptions: Establishing gender‐based treatment specialty facilities as a strategy to motivate South African young women to seek treatment for substance use disorders

open access: yesJournal of Community Psychology, Volume 51, Issue 1, Page 182-200, January 2023., 2023
Abstract South Africa alongside other low‐middle‐income countries have been some of the hardest hit by the substance use scourge. The study sought to identify and measure treatment barriers among young adults (18–29 years) living with substance use disorders, and then examine the role of gender in the perception of treatment barriers, with a view to ...
Tichaenzana Nyashanu, Herbert Zirima
wiley   +1 more source

Drug‐Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund   +5 more
wiley   +1 more source

Nitrous Oxide Acts Directly at the Mu Opioid Receptor [PDF]

open access: bronze, 1985
Mark A. Gillman, F J Lichtigfeld
openalex   +1 more source

Multianalyte Approach—Including Automated Preparation of Calibrators—for Validated Quantification of 82 Drugs in Whole Blood by Liquid Chromatography–Tandem Mass Spectrometry

open access: yesDrug Testing and Analysis, EarlyView.
In forensic bioanalysis, often multianalyte approaches are used given their increased effectiveness but can be difficult to develop and maintain in the laboratory, for example, in terms of calibrator solution preparation. A fast, simple, and robust liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the quantification of 82 classic ...
Andrea E. Steuer   +3 more
wiley   +1 more source

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