Results 11 to 20 of about 2,576,885 (397)
Molecular Pharmacology of δ-Opioid Receptors [PDF]
Pharmacological Reviews, 2016 Louis Gendron +4 more
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Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine [PDF]
Advanced Science, EarlyView.Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Xiao‐Fan Shen +6 more
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Biased ligands at opioid receptors: Current status and future directions
Science Signaling, 2021 Ongoing efforts to identify and characterize biased ligands for opioid receptors are discussed. The opioid crisis represents a major worldwide public health crisis that has accelerated the search for safer and more effective opioids.
Tao Che +3 more
semanticscholar +1 more source
Pharmaceuticals, 2022 This paper proposes the design of combination opioid–adrenergic tethered compounds to enhance efficacy and specificity, lower dosage, increase duration of activity, decrease side effects, and reduce risk of developing tolerance and/or addiction ...
Robert Root-Bernstein
doaj +1 more source
Molecular mechanisms of opioid tolerance: From opioid receptors to inflammatory mediators (Review)
Experimental and Therapeutic Medicine, 2021 Opioids are considered the most effective analgesics for the treatment of both acute and chronic pain. However, prolonged opioid use can induce a certain level of tolerance to its analgesic effects, leading to a reduction in its effectiveness, addiction ...
Jie Zhou +7 more
semanticscholar +1 more source
Structure-based discovery of opioid analgesics with reduced side effects
Nature, 2016 Aashish Manglik +2 more
exaly +2 more sources
Molecules, 2022 Opioid receptors are members of the group of G protein-couple receptors, which have been proven to be effective targets for treating severe pain. The interactions between the opioid receptors and corresponding ligands and the receptor’s activation by ...
Peng Xie +8 more
doaj +1 more source
Cocaine modulates the expression of opioid receptors and miR-let-7d in zebrafish embryos. [PDF]
PLoS ONE, 2012 Prenatal exposure to cocaine, in mammals, has been shown to interfere with the expression of opioid receptors, which can have repercussions in its activity.
Roger López-Bellido +3 more
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Bidirectional Regulation of Opioid and Chemokine Function
Frontiers in Immunology, 2020 The opioid family of GPCRs consists of the classical opioid receptors, designated μ-, κ-, and δ-opioid receptors, and the orphanin-FQ receptor, and these proteins are expressed on both neuronal and hematopoietic cells.
Thomas J. Rogers
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Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use
Addiction Neuroscience, 2023 Opioid use and opioid use disorder are characterized by sex and gender differences, and some of these differences may be mediated by differences in the hormonal milieu within and across individuals.
Sarah B. Ethridge, Mark A. Smith
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