Results 11 to 20 of about 72,097 (314)

Opioids and opioid receptors; understanding pharmacological mechanisms as a key to therapeutic advances and mitigation of the misuse crisis [PDF]

BJA Open, 2023
Opioids are a mainstay in acute pain management and produce their effects and side effects (e.g., tolerance, opioid-use disorder and immune suppression) by interaction with opioid receptors.
David G. Lambert
doaj   +2 more sources

Selective targeting of mu opioid receptors to primary cilia [PDF]

Cell Reports
Summary: Opioid receptors are therapeutically important G protein-coupled receptors (GPCRs) with diverse neuromodulatory effects. The functional consequences of opioid receptor activation are known to depend on receptor location in the plasma membrane ...
Rita R. Fagan, David F. Lee, Matan Geron, Grégory Scherrer, Mark von Zastrow, Aliza T. Ehrlich   +5 more
doaj   +2 more sources

Biased, Bitopic, Opioid–Adrenergic Tethered Compounds May Improve Specificity, Lower Dosage and Enhance Agonist or Antagonist Function with Reduced Risk of Tolerance and Addiction

Pharmaceuticals, 2022
This paper proposes the design of combination opioid–adrenergic tethered compounds to enhance efficacy and specificity, lower dosage, increase duration of activity, decrease side effects, and reduce risk of developing tolerance and/or addiction ...
Robert Root-Bernstein
doaj   +1 more source

Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain

Frontiers in Molecular Neuroscience, 2022
Opioids mediate their effects via opioid receptors: mu, delta, and kappa. At the neuronal level, opioid receptors are generally inhibitory, presynaptically reducing neurotransmitter release and postsynaptically hyperpolarizing neurons.
Kaitlin C. Reeves, Kaitlin C. Reeves, Nikhil Shah, Nikhil Shah, Braulio Muñoz, Brady K. Atwood, Brady K. Atwood   +6 more
doaj   +1 more source

Opioid receptors [PDF]

BJA Education, 2005
84670
McDonald, J, Lambert, DG
openaire   +4 more sources

Computational Methods for Understanding the Selectivity and Signal Transduction Mechanism of Aminomethyl Tetrahydronaphthalene to Opioid Receptors

Molecules, 2022
Opioid receptors are members of the group of G protein-couple receptors, which have been proven to be effective targets for treating severe pain. The interactions between the opioid receptors and corresponding ligands and the receptor’s activation by ...
Peng Xie, Junjie Zhang, Baiyu Chen, Xinwei Li, Wenbo Zhang, Mengdan Zhu, Wei Li, Jianqi Li, Wei Fu   +8 more
doaj   +1 more source

Bidirectional Regulation of Opioid and Chemokine Function

Frontiers in Immunology, 2020
The opioid family of GPCRs consists of the classical opioid receptors, designated μ-, κ-, and δ-opioid receptors, and the orphanin-FQ receptor, and these proteins are expressed on both neuronal and hematopoietic cells.
Thomas J. Rogers
doaj   +1 more source

Cocaine modulates the expression of opioid receptors and miR-let-7d in zebrafish embryos. [PDF]

PLoS ONE, 2012
Prenatal exposure to cocaine, in mammals, has been shown to interfere with the expression of opioid receptors, which can have repercussions in its activity.
Roger López-Bellido, Katherine Barreto-Valer, Fátima Macho Sánchez-Simón, Raquel E Rodríguez   +3 more
doaj   +1 more source

Nucleus Tractus Solitarius Neurons Activated by Hypercapnia and Hypoxia Lack Mu Opioid Receptor Expression

Frontiers in Molecular Neuroscience, 2022
Impaired chemoreflex responses are a central feature of opioid-induced respiratory depression, however, the mechanism through which mu opioid receptor agonists lead to diminished chemoreflexes is not fully understood.
Sebastian N. Maletz, Brandon T. Reid, Adrienn G. Varga, Adrienn G. Varga, Erica S. Levitt, Erica S. Levitt   +5 more
doaj   +1 more source

Opioid Receptors in Immune and Glial Cells—Implications for Pain Control

Frontiers in Immunology, 2020
Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Halina Machelska, Melih Ö. Celik
doaj   +1 more source