Results 241 to 250 of about 2,576,885 (397)

Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abundantly expressed in MSNs, is a promising biomarker of striatal integrity, but region‐specific associations and its potential for early‐stage ...
Mena Farag, Michael J. Murphy, Nicola Z. Hobbs, Michela Leocadi, Kate Fayer, Olivia Thackeray, Johan Gobom, Marc Ciosi, Amanda Heslegrave, Henrik Zetterberg, Douglas R. Langbehn, Darren G. Monckton, Edward J. Wild, Sarah J. Tabrizi, Rachael I. Scahill   +14 more
wiley   +1 more source

Activation of the Carotid Body by Kappa Opioid Receptors Mitigates Fentanyl-Induced Respiratory Depression. [PDF]

Function (Oxf)
Peng YJ, Nanduri J, Wang N, Xie Z, Fox AP, Prabhakar NR.   +5 more
europepmc   +1 more source

Targeting Opioid Receptors in Addiction and Drug Withdrawal: Where Are We Going? [PDF]

Int J Mol Sci, 2023
Tabanelli R, Brogi S, Calderone V.
europepmc   +1 more source

Innovation in Rural Nonprofits: Which Organizational Capacities Matter Most?

Nonprofit Management and Leadership, EarlyView.
ABSTRACT This research note draws on theory and empirical research from the broader fields of management, organizational capacity, and innovation to examine how specific organizational capacities relate to innovation in a sample of 107 rural nonprofit organizations in a Southeastern U.S. state.
Kristina Jaskyte, Ashley Hunter, Lina Danusevičienė   +2 more
wiley   +1 more source

The dopaminergic effects of esketamine are mediated by a dual mechanism involving glutamate and opioid receptors. [PDF]

Mol Psychiatry
Rizzo A, Garçon-Poca MZ, Essmann A, Souza AJ, Michaelides M, Ciruela F, Bonaventura J.   +6 more
europepmc   +1 more source

Correction: Kappa opioid receptors as modulators of novelty processing. [PDF]

Neuropsychopharmacology, 2023
Braden K, Castro DC.
europepmc   +1 more source

Association of Glucagon‐Like Peptide‐1 Receptor Agonists With Cancer Risk in Older Adults With Type 2 Diabetes

Obesity, EarlyView.
ABSTRACT Objective The real‐world evidence on the association between glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and cancer risk remains limited and mixed. Methods In 2013–2020 national Medicare claims data, we included cancer‐naïve patients with type 2 diabetes (T2D). We identified those who initiated GLP‐1 RA, sodium‐glucose cotransporter 2
Ying Lu, Hao Dai, Huilin Tang, William T. Donahoo, Thomas J. George, Ramon C. Sun, Sizun Jiang, Aik Choon Tan, Yi Guo, Jonathan D. Licht, John M. Allen, Kelvin P. Lee, Jingchuan Guo, Jiang Bian   +13 more
wiley   +1 more source

Supraspinal kappa-opioid receptors: new therapeutic strategies for pain, pruritus, and negative emotions. [PDF]

Exp Brain Res
Zhang L, Zhou S, Yan L, Li X, Ju Y, Wu B, Wang H, Wang J, Sun Y.   +8 more
europepmc   +1 more source

Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis

ChemistryOpen, EarlyView.
The study demonstrated that thidiazine compounds potentiated the action of antibiotics. The compounds associated with norfloxacin against S. aureus showed greater significance in relation to the other medications. The indiscriminate use of antibiotics has led to the selection of resistant bacterial strains, significantly reducing the effectiveness of ...
João Arthur de Oliveira Borges, Priscilla Ramos Freitas, Isaac Moura Araújo, Ray Silva de Almeida, Igor José dos Santos Nascimento, João Xavier de Araújo‐Júnior, Edeildo Ferreira da Silva‐Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Radosław Kowalski, Grażyna Kowalska, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Ana Carolina Justino de Araújo   +15 more
wiley   +1 more source

Ketamine-induced static and dynamic functional connectivity changes are modulated by opioid receptors and biological sex in rats. [PDF]

Neuropsychopharmacology
Grasso V, Tennyson J, Airan RD, Di Ianni T.   +3 more
europepmc   +1 more source