Results 271 to 280 of about 135,910 (355)

Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: Achieving selectivity against the μ opioid and nociceptin/orphanin FQ peptide (NOP) receptors

, 2006
Daniela Alberati, Simona Ceccarelli, Synèse Jolidon, Eva A. Krafft, Anke Kurt, Axel Maier, Emmanuel Pinard, Henri Stalder, Deborah Studer, Andrew W. Thomas, Daniel Zimmerli   +10 more
openalex   +1 more source

Contingency management interventions for substance use and addictive behaviours: Review of the United Kingdom evidence base

Addiction, EarlyView.
Abstract Background and aims Substance use and other addictive behaviours including gambling remain major public health concerns in the UK. Despite the effectiveness of substance use treatment approaches, treatment adherence and success rates remain low.
Carol‐Ann Getty, Tricia McQuarrie, Eileen Brobbin   +2 more
wiley   +1 more source

Drug use among people in prison: A global review of epidemiology, harms and interventions

Addiction, EarlyView.
Abstract Background and aims People who use drugs are overrepresented in the criminal justice system. We aimed to provide a broad synthesis of the epidemiology, harms and interventions related to drug use and drug use disorders among incarcerated adults worldwide, and highlight gaps in evidence and practice.
Louis Favril, John Strang, Seena Fazel
wiley   +1 more source

Opioid drug seeking after early-life adversity: a role for delta opioid receptors. [PDF]

Addict Neurosci
Levis SC, Birnie MT, Xie Y, Kamei N, Kulkarni PV, Montesinos JS, Perrone CR, Cahill CM, Baram TZ, Mahler SV.   +9 more
europepmc   +1 more source

Substance Use and Sex Index version 2 (SUSI‐2): Validation of a brief questionnaire for the measurement of behaviours associated with transmission of blood borne viruses and sexually transmitted infections

Addiction, EarlyView.
Abstract Aims This study sought to validate a community‐acceptable Substance Use & Sex Index (SUSI) for use in substance use intervention research. SUSI aims to measure behaviours associated with the transmission of blood‐borne viruses (BBV) and sexually transmitted infections (STI) among people who use substances and incorporate contemporary sexual ...
Brendan Clifford, Raimondo Bruno, Liam Acheson, Michael E. Cecilio, Krista J. Siefried, Jack Freestone, Vincent J. Cornelisse, Brendan Crozier, Nicky Bath, Nadine Ezard   +9 more
wiley   +1 more source

Retraction: By up-regulating μ- and δ-opioid receptors, neuron-restrictive silencer factor knockdown promotes neurological recovery after ischemia. [PDF]

Oncotarget
Liang HM, Geng LJ, Shi XY, Zhang CG, Wang SY, Zhang GM.   +5 more
europepmc   +1 more source

Exploring the genetic overlap between substance use disorder and educational attainment

Addiction, EarlyView.
Abstract Background and aims Substance use disorder (SUD) is a polygenic psychiatric condition characterized by persistent drug use despite negative consequences. Several studies support that higher cognitive performance and educational attainment (EA) are associated with a reduced risk for SUD.
Judit Cabana‐Domínguez, Laura Vilar‐Ribó, María Soler Artigas, Silvia Alemany, Natalia Llonga, Pau Carabí‐Gassol, Uxue Zubizarreta‐Arruti, Valeria Macias‐Chimborazo, Lara Grau‐López, Constanza Daigre, Elena Ros‐Cucurull, Raúl Felipe Palma‐Alvarez, Germán Ortega‐Hernández, Noèlia Fernàndez‐Castillo, Bru Cormand, Josep Antoni Ramos‐Quiroga, Marta Ribasés   +16 more
wiley   +1 more source

Docking Simulations of G-Protein Coupled Receptors Uncover Crossover Binding Patterns of Diverse Ligands to Angiotensin, Alpha-Adrenergic and Opioid Receptors: Implications for Cardiovascular Disease and Addiction. [PDF]

Biomolecules
Ridgway H, Moore GJ, Gadanec LK, Matsoukas JM.   +3 more
europepmc   +1 more source

5‐Methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–severe AUD enrolled in a standard of care, 10‐week programme of relapse‐prevention oriented Cognitive ...
John Marsden, Michael Kelleher, Fiona Dunbar, Anna O. Ermakova, Luke Mitcheson, Claire Roberts, James J. Rucker, Gemma Scott, Ivan Saeger, Francesca Small, Mathieu Seynaeve   +10 more
wiley   +1 more source

Xylazine as an emerging new psychoactive substance; focuses on both 5-HT₇ and κ-opioid receptors' molecular interactions and isosteric replacement. [PDF]

Arch Pharm (Weinheim)
Floresta G, Granzotto A, Patamia V, Arillotta D, Papanti GD, Guirguis A, Corkery JM, Martinotti G, Sensi SL, Schifano F.   +9 more
europepmc   +1 more source