Results 301 to 310 of about 2,576,885 (397)

Impact of renal impairment on the pharmacokinetic profile of intravenous difelikefalin, a kappa opioid receptor agonist for the treatment of pruritus

Robert H. Spencer, Patrick K. Noonan, Thomas Marbury, Frédérique Menzaghi   +3 more
openalex   +1 more source

Factors Influencing Agonist Potency and Selectivity for the Opioid δ Receptor Are Revealed in Structure−Activity Relationship Studies of the 4-[(N-Substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides

, 2001
James B. Thomas, Xavier M. Herault, Richard B. Rothman, Robert N. Atkinson, Jason P. Burgess, S. Wayne Mascarella, Christina M. Dersch, Heng Xu, J.L. Flippen-Anderson, Clifford George, F. Ivy Carroll   +10 more
openalex   +1 more source

Implementation of geriatric clinical decision support in the emergency department for potentially inappropriate medications

Academic Emergency Medicine, EarlyView.
Abstract Objectives The use of potentially inappropriate medications (PIMs) in older adults in the emergency department (ED) is associated with increased risk of readmissions and adverse drug reactions. We sought to assess the impact of electronic health record (EHR)‐based geriatric clinical decision support (CDS) on adherence to geriatric ...
Gina A. Elder, Kevin King, Marc Willner, Matthew J. Campbell, Baruch S. Fertel, Saket Saxena, Stephen Meldon   +6 more
wiley   +1 more source

A systematic review of interventions for persons living with dementia: The Geriatric ED Guidelines 2.0

Academic Emergency Medicine, EarlyView.
Abstract Background The increasing prevalence of dementia poses significant challenges for emergency department (ED) care, as persons living with dementia (PLWD) more frequently experience adverse outcomes such as delirium, prolonged stays, and higher mortality rates.
Sangil Lee, Michelle Suh, Luna Ragsdale, Justine Seidenfeld, James D. van Oppen, Lauren Lapointe‐Shaw, Carolina Diniz Hooper, James Jaramillo, Annie B. Wescott, Alexander X. Lo, Kaiho Hirata, Maura Kennedy, Lauren Cameron Comasco, Christopher R. Carpenter, Teresita M. Hogan, Shan W. Liu, Geriatric ED Guidelines Dementia Writing Group, Scott Dresden, Angel Li, Cameron J. Gettel, R. Doreen Monks   +20 more
wiley   +1 more source

Xylazine as an emerging new psychoactive substance; focuses on both 5-HT₇ and κ-opioid receptors' molecular interactions and isosteric replacement. [PDF]

Arch Pharm (Weinheim)
Floresta G, Granzotto A, Patamia V, Arillotta D, Papanti GD, Guirguis A, Corkery JM, Martinotti G, Sensi SL, Schifano F.   +9 more
europepmc   +1 more source

The kappa-opioid receptor system : a role in ethanol withdrawal severity?

, 2004
Amy S. Beadles-Bohling
openalex   +1 more source

Severe Hyponatremia in the Emergency Department Incidence of Cerebral Edema and Risk of Osmotic Demyelination Syndrome

Academic Emergency Medicine, EarlyView.
ABSTRACT Study Objective Treatment strategies in severe hyponatremia aim at rapid sodium correction to prevent or treat cerebral edema but limit sodium rise to prevent osmotic demyelination syndrome (ODS). The true risk of edema or ODS in ED patients is unknown.
Volker Burst, Ramon Rabii, Julian Peto‐Madew, Thorsten Persigehl, Stefan Haneder, Matthias Johannes Hackl, Christoph Hüser, Moritz Trappe, Sadrija Cukoski, Kathrin Möllenhoff, Victor Suárez   +10 more
wiley   +1 more source

Editorial: Opioids and opioid receptors in pain, addiction, and mood disorders. [PDF]

Front Psychiatry
Qiu Y, Wang YJ.
europepmc   +1 more source

Cluster‐Randomized Trials in Emergency Care Research

Academic Emergency Medicine, EarlyView.
ABSTRACT Objective Cluster‐randomized trials (also called group‐randomized trials) are increasingly common in emergency care research. In such trials, groups of participants are allocated to different interventions based on naturally occurring “clusters,” such as clinics, hospitals, or emergency medical services agencies. In this methodological review,
Howard S. Kim, Jacob M. Schauer, Jody D. Ciolino   +2 more
wiley   +1 more source

Peripherally Restricted Activation of Opioid Receptors Influences Anxiety-Related Behaviour and Alters Brain Gene Expression in a Sex-Specific Manner. [PDF]

Int J Mol Sci
Parkar N, Young W, Olson T, Hurst C, Janssen P, Spencer NJ, McNabb WC, Dalziel JE.   +7 more
europepmc   +1 more source