Results 311 to 320 of about 2,447,948 (384)

Disruption of the kappa -opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa -agonist U-50,488H and attenuates morphine withdrawal

, 1998
Frédéric Simonin, Olga Valverde, Claire Smadja, Susan Slowe, Ian Kitchen, Andrée Dierich, Marianne Le Meur, Bernárd P. Roques, Rafael Maldonado, Brigitte L. Kieffer   +9 more
openalex   +1 more source

A learning health system model for addressing substance use: Denver Health Center for Addiction Medicine

Learning Health Systems, EarlyView.
Abstract Introduction Substance use disorders (SUDs) continue to place heavy burdens on patients, health systems, and communities. Rapidly evolving treatment for SUDs requires health systems that can efficiently and effectively assess data and integrate evidence to practice.
Emily Bacon, Laura J. Podewils, Brooke Bender, Joshua Blum, Christian Thurstone, Alia Al‐Tayyib, John Mills, Alexandra R. Tillman, Judith Shlay   +8 more
wiley   +1 more source

Cyclical medication management interventions in health care settings: A systematic review

Learning Health Systems, EarlyView.
Abstract Introduction It is estimated that one in 30 patients experiences at least one preventable medication‐related harm while receiving care. Cyclical medicine improvement interventions, where health systems continuously collect data, implement prescribing/dispensing interventions, review outcomes, and revise the intervention, have demonstrated ...
Isabelle Meulenbroeks, Crisostomo Mercado, Rachel Urwin, Karla Seaman, Anna Kelly, Osman Qadri, Johanna Westbrook I.   +6 more
wiley   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Restless Legs Syndrome and Impulsive Decision‐Making: Impact of Symptom Severity, Chronotype and Interoception

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Restless Legs Syndrome (RLS) is a neurological disorder reported to be associated with impulsivity and impairments in interoception and emotional regulation. However, limited research has explored the combined influence of RLS severity, psychological factors, and chronotype on impulsive decision‐making and risk‐taking behavior in ...
Giacomo Carollo, Riccardo Quinci, Gloria Pompea Mingolla, Angela Sandri, Michele Tinazzi, Elena Antelmi   +5 more
wiley   +1 more source

Expert Consensus on the Diagnosis and Treatment of Malignant Pericardial Mesothelioma

Med Research, EarlyView.
ABSTRACT Primary malignant pericardial mesothelioma (PMPM), a rare pericardium‐derived malignancy, urgently requires standardized diagnostic and therapeutic protocols. This consensus, established by the Chinese Alliance of Research for Mesothelioma (ChARM) through the integration of evidence‐based research and multicenter clinical expertise, addresses ...
Qing Ji, Chunwei Xu, Qian Wang, Wenxian Wang, Zhenying Guo, Ziming Li, Zhengbo Song, Aijun Liu, Jinpu Yu, Wenzhao Zhong, Zhijie Wang, Wenfeng Fang, Yongchang Zhang, Jingjing Liu, Shirong Zhang, Xiuyu Cai, Anwen Liu, Ping Zhan, Hongbing Liu, Tangfeng Lv, Liyun Miao, Lingfeng Min, Gen Lin, Long Huang, Chen Yu, Jingping Yuan, Zhansheng Jiang, Feng Wang, Xingxiang Pu, Chuangzhou Rao, Dongqing Lv, Yinghua Ji, Xianbin Liang, Zongyang Yu, Xiaoyan Li, Chuanhao Tang, Chengzhi Zhou, Junping Zhang, Xuelei Ma, Hui Guo, Qian Chu, Rui Meng, Jingxun Wu, Huaiqing Xiao, Jin Zhou, Zhengfei Zhu, Hongmei Zhang, Yingshi Piao, Xiaofeng Chen, Xuewen Liu, Enyong Dai, Yu Yao, Jian Zhang, Weiwei Pan, Fei Pang, Fan Wu, Zhiying Shao, Ling Xu, Liping Wang, Jianfei Tu, Yu Zhang, Xinqing Lin, Jing Cai, Jian Feng, Jisheng Li, Xiaodong Jiao, Kainan Li, Huijing Feng, Lin Wang, Yingying Du, Binbin Song, Xuefei Shi, Wenfeng Li, Xiaomin Niu, Jianhui Huang, Yina Wang, Yue Feng, Yinbin Zhang, Pingli Sun, Hong Wang, Dongmei Yuan, Yanwen Yao, Dong Wang, Mingxiang Ye, Zhaofeng Wang, Yue Hao, Jianan Jin, Zhen Wang, Bing Wan, Donglai Lv, Shengjie Yang, Lin Shi, Bihui Li, Zhang Zhang, Zhongwu Li, Zhefeng Liu, Nong Yang, Lin Wu, Miao Li, Xiaobing Li, Guansong Wang, Jiandong Wang, Yong Fang, Yuan Li, Yiping Zhang, Xixu Zhu, Yi Shen, Ke Wang, Shenglin Ma, Yong Song, Youcai Zhu, Yuanzhi Lu, Meiyu Fang   +112 more
wiley   +1 more source

Evidence of Involvement of the Calcitonin Gene‐Related Peptide in Restless Legs Syndrome

Movement Disorders, EarlyView.
Abstract Background Restless legs syndrome (RLS) is a common sensory‐motor disorder characterized by an urge to move the legs, often with unpleasant sensations, particularly during rest. Current treatments include iron supplementation, dopamine agonists, and opioids, but new therapeutic approaches are needed.
Maria P. Mogavero, Mojibola Fowowe, Akeem Sanni, Mona Goli, Giuseppe Lanza, Francesca L'Episcopo, Luigi Ferini‐Strambi, Yehia Mechref, Raffaele Ferri   +8 more
wiley   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, EarlyView.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Transurethral Fulguration of Hunner Lesion Was Effective for Primary Management of Pelvic Pain in Patients With Interstitial Cystitis: A Long‐Term Follow‐Up Study

Neurourology and Urodynamics, EarlyView.
ABSTRACT Objective This study aimed to analyze the outcomes of clinical management of patients with interstitial cystitis (IC). Patients and Methods We retrospectively analyzed the electronic medical records of patients with IC who visited outpatient clinics with pelvic pain between October 2005 and December 2019.
Hyun Ju Jeong, Yu Jin Kang, Min Soo Choo, Seong Jin Jeong, Seung‐June Oh   +4 more
wiley   +1 more source