Results 341 to 350 of about 2,576,885 (397)
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Opioids, Receptors, and Immunity
1993The results achieved by those seeking to determine whether opioids and other drugs of abuse can affect immunity are quite astonishing given the short period of time that research has focused on this area. Despite the fact that there is no longer any question that opioids produce a variety of effects on the immune system, the extent and significance of ...
M W, Adler +4 more
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Oligomerization of opioid receptors
Methods, 2002Opioid receptors belong to the family of G-protein-coupled receptors characterized by their seven transmembrane domains. The activation of these receptors by agonists such as morphine and endogenous opioid peptides leads to the activation of inhibitory G-proteins followed by a decrease in the levels of intracellular cAMP.
Ivone, Gomes +3 more
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Current Protocols in Pharmacology, 1998
AbstractOpioid receptors mediate the pharmacologic actions of morphine‐like analgesics, a class of drugs that are important clinical agents which are also widely abused socially as a result of their euphorogenic and addictive properties. Cloning of the opioid receptors has confirmed the original postulate that there are only three classes of opioid ...
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AbstractOpioid receptors mediate the pharmacologic actions of morphine‐like analgesics, a class of drugs that are important clinical agents which are also widely abused socially as a result of their euphorogenic and addictive properties. Cloning of the opioid receptors has confirmed the original postulate that there are only three classes of opioid ...
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NeuroMolecular Medicine, 2004
Opioid receptors are regulated by multiple mechanisms, which are believed to contribute to the physiological plasticity of the endogenous opioid system in response to natural neuropeptides, as well as clinically relevant opiate drugs. Considerable progress has been made in elucidating molecular and cellular mechanisms of opioid receptor regulation. The
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Opioid receptors are regulated by multiple mechanisms, which are believed to contribute to the physiological plasticity of the endogenous opioid system in response to natural neuropeptides, as well as clinically relevant opiate drugs. Considerable progress has been made in elucidating molecular and cellular mechanisms of opioid receptor regulation. The
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Pharmaceutisch Weekblad Scientific Edition, 1990
A receptor site is considered to be a transducing factor for effect of the natural ligand. Endorphins and the drugs that mimic their effects (the opiates) are important for analgesia, and consequently the receptor sites involved in actions of opioid drugs are to be considered as relevant to the transmission of pain.
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A receptor site is considered to be a transducing factor for effect of the natural ligand. Endorphins and the drugs that mimic their effects (the opiates) are important for analgesia, and consequently the receptor sites involved in actions of opioid drugs are to be considered as relevant to the transmission of pain.
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Opioid receptors and opioid pharmacodynamics
2005Abstract Opioids have a long and rich pharmacology. They are widely used throughout medicine and have been invaluable. However, they come with problems, including side effects such as constipation, respiratory depression and sedation, as well as the potential of abuse.
Mellar P Davis, Gavril W Pasternak
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Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors
Nature Chemical Biology, 2020Jan Möller +11 more
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1990
Abstract Evidence for the heterogeneity of opioid receptor sites in the CNS has been provided by a variety of studies. At least three classes of binding sites have been identified and designated as μ (morphine), δ (enkephalin) and x (dynorphin).
Catherine D Demoliou-mason +1 more
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Abstract Evidence for the heterogeneity of opioid receptor sites in the CNS has been provided by a variety of studies. At least three classes of binding sites have been identified and designated as μ (morphine), δ (enkephalin) and x (dynorphin).
Catherine D Demoliou-mason +1 more
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2007
AbstractThere are four members of the opioid receptor family mu, delta, kappa and ORL-1. G protein linked receptors. Acute response to ligand binding differs from chronic response. Acute response includes dimerisation, endocytosis and inhibition of adenylyl cyclase, cAMP systems and hyperpolarization of the neuron.
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AbstractThere are four members of the opioid receptor family mu, delta, kappa and ORL-1. G protein linked receptors. Acute response to ligand binding differs from chronic response. Acute response includes dimerisation, endocytosis and inhibition of adenylyl cyclase, cAMP systems and hyperpolarization of the neuron.
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