Patterns of Routes of Administration and Drug Tampering for Nonmedical Opioid Consumption: Data Mining and Content Analysis of Reddit Discussions [PDF]
J Med Internet Res 2021;23(1):e21212, 2021 The complex unfolding of the US opioid epidemic in the last 20 years has been the subject of a large body of medical and pharmacological research, and it has sparked a multidisciplinary discussion on how to implement interventions and policies to effectively control its impact on public health.
arxiv +1 more source
The opioid receptor: emergence through millennia of pharmaceutical sciences
Frontiers in Pain Research, 2023 Throughout history humanity has searched for an optimal approach to the use of opioids that maximizes analgesia while minimizing side effects. This review reflects upon the conceptualization of the opioid receptor and the critical role that the ...
Carolyn A. Fairbanks +4 more
doaj +1 more source
Targeting multiple opioid receptors – improved analgesics with reduced side effects?
British Journal of Pharmacology, 2018 Classical opioid analgesics, including morphine, mediate all of their desired and undesired effects by specific activation of the μ‐opioid receptor (μ receptor).
T. Günther +7 more
semanticscholar +1 more source
A Biased View of μ-Opioid Receptors?
Molecular Pharmacology, 2019 The field of biased agonism has grown substantially in recent years and the μ-opioid receptor has been one of the most intensively studied receptor targets for developing biased agonists.
Alexandra E. Conibear, E. Kelly
semanticscholar +1 more source
Receptors for morphine and opioids
General Pharmacology: The Vascular System, 1976 Two points concerning enzymatic systems acting on disposal of morphine are discussed, namely the multiplicity of glucuronyltransferase and the effect of nalorphine on N-demethylation of morphine. Evidences of the presence of at least two different glucuronyltransferases in microsomes of rat liver, kidney and intestine are presented. These evidences are
Sánchez, Emílio +2 more
openaire +4 more sources
Allostery at opioid receptors: modulation with small molecule ligands
British Journal of Pharmacology, 2018 Opioid receptors are 7‐transmembrane domain receptors that couple to heterotrimeric G proteins. The endogenous ligands for opioid receptors are peptides which bind to the orthosteric site on the receptors.
Kathryn E. Livingston, J. Traynor
semanticscholar +1 more source
Activation profiles of opioid ligands in HEK cells expressing δ opioid receptors
BMC Neuroscience, 2002 Background The aim of the present study was to characterize the activation profiles of 15 opioid ligands in transfected human embryonic kidney cells expressing only δ opioid receptors.
Clark J +3 more
doaj +1 more source
The Use of Computational Approaches in the Discovery and Mechanism Study of Opioid Analgesics
Frontiers in Chemistry, 2020 Opioid receptors that belong to class A G protein-coupled receptors (GPCRs) are vital in pain control. In the past few years, published high-resolution crystal structures of opioid receptor laid a solid basis for both experimental and computational ...
Bangyi Zhao, Wei Li, Lijie Sun, Wei Fu
doaj +1 more source
Machine-learning Analysis of Opioid Use Disorder Informed by MOR, DOR, KOR, NOR and ZOR-Based Interactome Networks [PDF]
arXiv, 2023 Opioid use disorder (OUD) continuously poses major public health challenges and social implications worldwide with dramatic rise of opioid dependence leading to potential abuse. Despite that a few pharmacological agents have been approved for OUD treatment, the efficacy of said agents for OUD requires further improvement in order to provide safer and ...
arxiv