Results 271 to 280 of about 714,581 (348)

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Health, Socioeconomic Status, and Opioid Use Disorder: Risk Factors Among Individuals With Nonmedical Opioid Use. [PDF]

Public Health Rep
Park K, Yang TC.
europepmc   +1 more source

Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro, Pietro Pola, Michela Argentieri, Alessia Frezza, Matilde Marini, Francesco De Logu, Valentina Albanese, Marie Soukupova, Davide Malfacini, Nurulain T. Zaveri, Romina Nassini, Dane D. Jensen, Pierangelo Geppetti, Girolamo Calò, Chiara Ruzza   +14 more
wiley   +1 more source

The role of emergency departments in opioid related harms: A qualitative study among emergency healthcare providers. [PDF]

PLoS One
Ten Pas C, Bahadoer V, Kramers C, Dahan A, Ellerbroek H, Holkenborg J, Sir O, Van Loon M, Schellekens A, Kraaijvanger N.   +9 more
europepmc   +1 more source

Association Between Congenital Heart Disease Complexity, Mental Health Conditions and Opioid Use Disorder. [PDF]

JACC Adv
Ho FY, Padiyath A, Nicolson SC, O'Byrne ML, Milas BL, Newcomb CW, Sutherland TN.   +6 more
europepmc   +1 more source

Development and evaluation of machine learning algorithms for the prediction of opioid-related deaths among UK patients with non-cancer pain. [PDF]

PLOS Digit Health
Benitez-Aurioles J, Raul Ramirez Medina C, Jenkins D, Peek N, Jani M.   +4 more
europepmc   +1 more source

Neurobiological mechanisms and treatment of empathic pain in nonsuicidal self-injury. [PDF]

Front Psychiatry
Xu SL, Wu D, Cai M, Li JW, Cui LB, Wu WJ.   +5 more
europepmc   +1 more source

Global burden and health inequalities of drug use disorders in adolescents and young adults from 1992 to 2021. [PDF]

Front Public Health
Bao R, Sun H, Zhang X, Zhao Z, Feng J, Jiang W.   +5 more
europepmc   +1 more source