Results 151 to 160 of about 45,788 (261)

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

British Journal of Pharmacology, EarlyView.
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton, Fraser Nunn, Erika Lace, Álvaro Lorente‐Macías, Rachel Toth, Asier Unciti‐Broceta, Tim G. Hales   +6 more
wiley   +1 more source

Umbilical Cord Methadone and Buprenorphine Levels and Neonatal Opioid Withdrawal Severity.

JAMA Netw Open
Townsel C, Turner M, Biroon F, Broni E, Willimas SAS, Burd I, Kelly J.   +6 more
europepmc   +1 more source

A comparison of dual vs. single diagnostic code approaches for neonatal opioid withdrawal syndrome surveillance in neonates ≥ 35 weeks gestational age. [PDF]

BMC Pediatr
Khan JY, Neuman HL, Groh JM, Feffer MG, Troeller PE, Christmon C, Dookeran KA.   +6 more
europepmc   +1 more source

GLP‐1 receptor activation attenuates chronic migraine‐like behaviour: Sex‐specific modulation of opioid‐ and endocannabinoid‐related pathways

British Journal of Pharmacology, EarlyView.
Background and Purpose Chronic migraine (CM) is a highly disabling condition that remains suboptimally treated. Metabolic disturbances may trigger migraine chronification, whereas impaired endogenous pain inhibition contributes to CM development. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), used for type 2 diabetes and obesity, show efficacy ...
Katarina Sićović, Katarina Nastić, Miroslav Dinić, Emilija Brdarić, Uroš Pecikoza, Maja Tomić, Ana Micov   +6 more
wiley   +1 more source

Early pharmacotherapy versus no pharmacotherapy: difference in skin conductance response to physical stimuli in infants with neonatal opioid withdrawal syndrome. [PDF]

BMC Pediatr
Mayo R, Edgar M, Sutton J, Holcomb L, Dickes L, Sherrill W, Charron E, Boyd J, Hudson J.   +8 more
europepmc   +1 more source

New anti‐inflammatory and remodelling drugs for unmet clinical needs in severe asthma and chronic obstructive pulmonary disease (COPD)

British Journal of Pharmacology, EarlyView.
There have been several step‐changes in asthma therapy, with the first being the use of inhaled short‐acting β2‐agonists as bronchodilators and the introduction of inhaled corticosteroids (ICS) to reduce airway inflammation. The next revolution was the advent of inhaled combinations of long‐acting bronchodilators together with inhaled corticosteroids ...
Ian M. Adcock
wiley   +1 more source

The efficacy and safety of short-acting, full agonist opioids for symptom management of opioid withdrawal. [PDF]

Addict Behav Rep
Azar P, Kim JJ, Wong J, Machado J, Budd G, Baldwin K, Siu JTP, Lau A.   +7 more
europepmc   +1 more source

Use of Weighted Blankets as Adjunct Therapy for Symptom Reduction Among Emergency Department Patients Receiving Buprenorphine for Opioid Withdrawal. [PDF]

Acad Emerg Med
LeSaint KT, Ager EE, Kaul P, Geier C, Smollin CG.   +4 more
europepmc   +1 more source

Machine Learning Model for Predicting Postoperative Pain in Cases of Irreversible Pulpitis

International Endodontic Journal, EarlyView.
ABSTRACT Aim Postoperative pain is a frequent clinical concern following endodontic treatment. This study aimed to develop and validate supervised machine learning models to predict the occurrence of postoperative pain in cases of irreversible pulpitis.
Pedro Felipe de Jesus Freitas, Ingrid Luiza Mendonça Cunha, Thalita de Paris Matos, Flares Baratto‐Filho, Bianca Marques de Mattos de Araujo, Manoel Damião Sousa‐Neto, Leandro de Moura Martins, Fernando José Herkrath, Emílio Carlos Sponchiado‐Júnior, Cristiano Miranda de Araujo   +9 more
wiley   +1 more source

The effects of vaped cannabis on the severity of naloxone-precipitated opioid withdrawal. [PDF]

Exp Clin Psychopharmacol
Jones JD, Martinez S, Arout C, Haney M, Castillo F, Manubay J, Perez F, Luba RR, Comer SD.   +8 more
europepmc   +1 more source