Results 21 to 30 of about 186,280 (306)

Relation between opioid consumption and inclusion of opioids in 137 national essential medicines lists

BMJ Global Health, 2020
Introduction Opioids are deemed essential medicines by the World Health Organization (WHO). However, many countries have inadequate access to them.
Carl Heneghan, Jeffrey K Aronson, Kamal R Mahtani, Georgia C Richards, Nav Persaud, Constantinos Koshiaris   +5 more
doaj   +1 more source

Maternal Methadone Destabilizes Neonatal Breathing and Desensitizes Neonates to Opioid-Induced Respiratory Frequency Depression

Frontiers in Physiology, 2021
Pregnant women and developing infants are understudied populations in the opioid crisis, despite the rise in opioid use during pregnancy. Maternal opioid use results in diverse negative outcomes for the fetus/newborn, including death; however, the ...
Austin D. Hocker, Nina R. Morrison, Matthew L. Selby, Adrianne G. Huxtable   +3 more
doaj   +1 more source

Risk of respiratory depression with opioids and concomitant gabapentinoids [PDF]

, 2017
IntroductionThe combination of opioids and central nervous system depressants such as benzodiazepines and barbiturates has an additive effect on the frequency of oversedation and respiratory depression requiring naloxone use in hospitalized patients ...
Chih Hsu, Kelly Lee, Cassia Yi, Savelloni, Julie, Kyle Edmonds, Lee, Kelly C, Yi, Cassia, Heather Gunter, Timothy Furnish, Rabia Atayee, Gunter, Heather, Hsu, Chih, Atayee, Rabia S, Furnish, Timothy, Edmonds, Kyle P, Julie Savelloni, Savelloni J, Hsu C, Lee KC, Atayee RS, Edmonds KP, Yi C, Gunter H, Furnish T   +23 more
core   +2 more sources

Should we be routinely co-prescribing naloxone for patients on long term opioids?

, 2021
Community naloxone supply to prevent fatal overdose needs to consider patients using pharmaceutical ...
Nielsen, Suzanne, Prathivadi, Pallavi
core   +1 more source

Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway

Cell Reports, 2020
Summary: Normally, opioids function in a receptor-dependent manner. They bind to opioid receptors, activate or inhibit receptor activation, and subsequently modulate downstream signal transduction.
Lining Liang, Jinlong Chen, Yuan Li, Xiaowei Lai, Hao Sun, Changpeng Li, Mengdan Zhang, Tingting Yang, Fei Meng, Ping-Yee Law, Horace H. Loh, Hui Zheng   +11 more
doaj   +1 more source

Epidemiological trends in opioid-only and opioid/polysubstance-related death rates among American Indian/Alaska Native populations from 1999 to 2019: a retrospective longitudinal ecological study

BMJ Open, 2022
Objectives The rate of drug overdose deaths in the USA has more than tripled since the turn of the century, and rates are disproportionately high among the American Indian/Alaska Native (AI/AN) population.
Fares Qeadan, Erin F Madden, Nana A Mensah, Benjamin Tingey, Jalene Herron, Alexandra Hernandez-Vallant, Kamilla L Venner, Kevin English, Amruta Dixit   +8 more
doaj   +1 more source

Causal effects of opioids on postpartum depression: a bidirectional, two-sample Mendelian randomization study

Frontiers in Psychiatry, 2023
BackgroundPostpartum depression is the most common psychiatric disorder in pregnant women during the postpartum period and requires early detection and treatment.
Yage Jiang, Donglei Wei, Yubo Xie, Yubo Xie   +3 more
doaj   +1 more source

The Opioid-Tolerant Patient: Opioid Optimization [PDF]

The Journal of Arthroplasty, 2020
Chronic opioid use and abuse continue to plague our country despite efforts to curtail their use. Patients on chronic opioids (opioids tolerant) who undergo total joint arthroplasty have been clearly shown to have higher rates of complications, infection, and early revision compared to the opioid-naïve patients.
Padma, Gulur, Amanda H, Nelli
openaire   +2 more sources

Safety of opioid patch initiation in Australian residential aged care [PDF]

, 2015
Explores opioid use by aged care facility residents before and after initiation of transdermal opioid patches. Abstract Objective: To explore opioid use by aged care facility residents before and after initiation of transdermal opioid patches. Design:
Lisa Pont, Svetla Gadzhanova, Elizabeth Roughead, Roughead, E.E., Pont, L.G., Gadzhanova, S.   +5 more
core   +1 more source

An integrative comparative study between ultrasound-guided regional anesthesia versus parenteral opioids alone for analgesia in emergency department patients with hip fractures: A systematic review and meta-analysis

Heliyon, 2022
Background: Emergency physicians play a major role in managing patients with hip fractures. The most commonly used pain management option is parenteral opioids. However, parenteral opioids are subjected to several adverse effects.
Hany A. Zaki, Haris Iftikhar, Nabil Shallik, Amr Elmoheen, Khalid Bashir, Eman E. Shaban, Aftab Mohammad Azad   +6 more
doaj   +1 more source