Results 11 to 20 of about 181,981 (311)

Maternal Methadone Destabilizes Neonatal Breathing and Desensitizes Neonates to Opioid-Induced Respiratory Frequency Depression

Frontiers in Physiology, 2021
Pregnant women and developing infants are understudied populations in the opioid crisis, despite the rise in opioid use during pregnancy. Maternal opioid use results in diverse negative outcomes for the fetus/newborn, including death; however, the ...
Austin D. Hocker, Nina R. Morrison, Matthew L. Selby, Adrianne G. Huxtable   +3 more
doaj   +1 more source

Epidemiological trends in opioid-only and opioid/polysubstance-related death rates among American Indian/Alaska Native populations from 1999 to 2019: a retrospective longitudinal ecological study

BMJ Open, 2022
Objectives The rate of drug overdose deaths in the USA has more than tripled since the turn of the century, and rates are disproportionately high among the American Indian/Alaska Native (AI/AN) population.
Fares Qeadan, Erin F Madden, Nana A Mensah, Benjamin Tingey, Jalene Herron, Alexandra Hernandez-Vallant, Kamilla L Venner, Kevin English, Amruta Dixit   +8 more
doaj   +1 more source

Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway

Cell Reports, 2020
Summary: Normally, opioids function in a receptor-dependent manner. They bind to opioid receptors, activate or inhibit receptor activation, and subsequently modulate downstream signal transduction.
Lining Liang, Jinlong Chen, Yuan Li, Xiaowei Lai, Hao Sun, Changpeng Li, Mengdan Zhang, Tingting Yang, Fei Meng, Ping-Yee Law, Horace H. Loh, Hui Zheng   +11 more
doaj   +1 more source

Causal effects of opioids on postpartum depression: a bidirectional, two-sample Mendelian randomization study

Frontiers in Psychiatry, 2023
BackgroundPostpartum depression is the most common psychiatric disorder in pregnant women during the postpartum period and requires early detection and treatment.
Yage Jiang, Donglei Wei, Yubo Xie, Yubo Xie   +3 more
doaj   +1 more source

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid-Related Adverse Events Following Surgery for Breast Cancer. [PDF]

Clin Pharmacol Ther
Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Lai JH, Avanceña ALV, Cata JP, Barner JC, Giordano SH, Park C, Zhao H, Evoy KE, Lin JK, Spencer JC, Chavez-MacGregor M, Hunt KK, Wanis KN.   +12 more
europepmc   +2 more sources

The Opioid-Tolerant Patient: Opioid Optimization [PDF]

The Journal of Arthroplasty, 2020
Chronic opioid use and abuse continue to plague our country despite efforts to curtail their use. Patients on chronic opioids (opioids tolerant) who undergo total joint arthroplasty have been clearly shown to have higher rates of complications, infection, and early revision compared to the opioid-naïve patients.
Padma, Gulur, Amanda H, Nelli
openaire   +2 more sources

Safety of opioid patch initiation in Australian residential aged care [PDF]

, 2015
Explores opioid use by aged care facility residents before and after initiation of transdermal opioid patches. Abstract Objective: To explore opioid use by aged care facility residents before and after initiation of transdermal opioid patches. Design:
Lisa Pont, Svetla Gadzhanova, Elizabeth Roughead, Roughead, E.E., Pont, L.G., Gadzhanova, S.   +5 more
core   +1 more source

An integrative comparative study between ultrasound-guided regional anesthesia versus parenteral opioids alone for analgesia in emergency department patients with hip fractures: A systematic review and meta-analysis

Heliyon, 2022
Background: Emergency physicians play a major role in managing patients with hip fractures. The most commonly used pain management option is parenteral opioids. However, parenteral opioids are subjected to several adverse effects.
Hany A. Zaki, Haris Iftikhar, Nabil Shallik, Amr Elmoheen, Khalid Bashir, Eman E. Shaban, Aftab Mohammad Azad   +6 more
doaj   +1 more source

Examining prevalence and correlates of smoking opioids in British Columbia: opioids are more often smoked than injected

Substance Abuse Treatment, Prevention, and Policy, 2021
Background British Columbia (BC) is in the midst of an opioid overdose crisis. Since 2017, smoking illicit drugs has been the leading mode of drug administration causing overdose death.
Stephanie Parent, Kristi Papamihali, Brittany Graham, Jane A. Buxton   +3 more
doaj   +1 more source

A Nationwide Hospital Claims Database Analysis of Real-World Patterns of Laxative Use for Opioid-Induced Constipation in Japanese Patients with Cancer

Pain and Therapy, 2023
Introduction Opioid-induced constipation (OIC) is one of the most common side effects in patients with cancer treated with opioid analgesics. The actual use of laxatives for OIC in Japan remains unelucidated.
Takahiro Higashibata, Takaomi Kessoku, Yasuhide Morioka, Yuichi Koretaka, Hirokazu Mishima, Hidetoshi Shibahara, Yuriko Masuda, Yasushi Ichikawa, Atsushi Nakajima, Takayuki Hisanaga   +9 more
doaj   +1 more source