Results 351 to 360 of about 512,940 (405)
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Opioid and non-opioid analgesics
Best Practice & Research Clinical Anaesthesiology, 2003Opioids are the most potent analgesics. Toxicity results either from effects mediated by variation in affinity and intrinsic efficacy at specific opioid receptors or, rarely, from a direct toxic effect of the drugs. For some adverse effects, opioids exhibit a 'dual pharmacology' whereby these effects are usually observed only in pain-free individuals ...
Gail Gillespie +2 more
openaire +3 more sources
Wide Variation and Overprescription of Opioids After Elective Surgery
Annals of Surgery, 2017Cornelius A Thiels +2 more
exaly +2 more sources
Opioid receptor polymorphismsand opioid abuse [PDF]
Pharmacogenomics, 2002 The sequencing of the human genome is only the first step. The next step is to determine the function of these genes and in particular, how alterations in specific genes lead to major human disorders. Many laboratories are now focusing on identifying and characterizing single nucleotide polymorphisms (SNPs), to determine which correlate in frequency ...
Andrew P. Smith, Nancy M. Lee
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Neuroimaging Clinics of North America, 2006
Many breakthrough scientific discoveries have been made using opioid imaging. Developments include the application of ever higher resolution whole-brain positron emission tomography (PET) scanners, the availability of several radioligands, the combination of PET with advanced structural imaging, advances in modeling macroparameters of PET ligand ...
Hammers, Alexander +1 more
openaire +4 more sources
Many breakthrough scientific discoveries have been made using opioid imaging. Developments include the application of ever higher resolution whole-brain positron emission tomography (PET) scanners, the availability of several radioligands, the combination of PET with advanced structural imaging, advances in modeling macroparameters of PET ligand ...
Hammers, Alexander +1 more
openaire +4 more sources
New England Journal of Medicine, 2011
To the Editor: We applaud the article by Okie (Nov. 18 issue)1 on the increasing number of overdose deaths, since we have seen far too many patients die prematurely of opioid overdoses. One topic was missing from this article: the usefulness of providing access to naloxone to be administered by laypersons to prevent death from an opioid overdose ...
Michelle McKenzie +2 more
openaire +7 more sources
To the Editor: We applaud the article by Okie (Nov. 18 issue)1 on the increasing number of overdose deaths, since we have seen far too many patients die prematurely of opioid overdoses. One topic was missing from this article: the usefulness of providing access to naloxone to be administered by laypersons to prevent death from an opioid overdose ...
Michelle McKenzie +2 more
openaire +7 more sources
Opioid and anti‐opioid peptides
Fundamental & Clinical Pharmacology, 1995Summary— The numerous endogenous opioid peptides (β‐endorphin, enkephalins, dynorphins…) and the exogenous opioids (such as morphine) exert their effects through the activation of receptors belonging to four main types: μ, Δ, k and ε. Opioidergic neurones and opioid receptors are largely distributed centrally and peripherally. It is thus not surprising
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Neurologic Clinics, 1993
The major clinical uses for opioids are to control pain, suppress cough, and to treat diarrhea. These drugs, however, have the potential for abuse. It is postulated that the significant mood-altering effects of opioids combined with their pharmacology, in which tolerance and physical and psychological dependence occur, account for their abuse liability.
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The major clinical uses for opioids are to control pain, suppress cough, and to treat diarrhea. These drugs, however, have the potential for abuse. It is postulated that the significant mood-altering effects of opioids combined with their pharmacology, in which tolerance and physical and psychological dependence occur, account for their abuse liability.
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Non-opioid actions of opioid peptides
Life Sciences, 2004Beside the well known actions of opioid peptides on mu-, delta- and kappa-opioid receptors, increasing amount of pharmacological and biochemical evidence has recently been published about non-opioid actions of various opioid peptides. These effects are not abolished by naloxone treatments.
Maria Wollemann, Sándor Benyhe
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1984
Publisher Summary Opioid peptides are endogenous or synthetic peptides characterized by a spectrum of pharmacological activity similar to that of morphine and other narcotic agonist drugs. This chapter describes the psychobiology of opiates by analyzing their neurochemical correlates at the brain level and the role of different receptor sites.
OLIVERIO, Alberto +2 more
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Publisher Summary Opioid peptides are endogenous or synthetic peptides characterized by a spectrum of pharmacological activity similar to that of morphine and other narcotic agonist drugs. This chapter describes the psychobiology of opiates by analyzing their neurochemical correlates at the brain level and the role of different receptor sites.
OLIVERIO, Alberto +2 more
openaire +4 more sources