Results 81 to 90 of about 241,172 (309)

Morphine for the Treatment of Pain in Sickle Cell Disease

open access: yesThe Scientific World Journal, 2015
Pain is a hallmark of sickle cell disease (SCD) and its treatment remains challenging. Opioids are the major family of analgesics that are commonly used for treating severe pain.
Mihir Gupta   +3 more
doaj   +1 more source

The dark side of opioids in pain management: basic science explains clinical observation

open access: yesPAIN Reports, 2016
. Introduction:. In the past 2 decades, opioids have been used increasingly for the treatment of persistent pain, and doses have tended to creep up. As basic science elucidates mechanisms of pain and analgesia, the cross talk between central pain and ...
Cyril Rivat, Jane Ballantyne
doaj   +1 more source

Opioid Toxicity [PDF]

open access: yesAcademic Forensic Pathology, 2017
In recent years, there has been a substantial increase in opioid use and abuse, and in opioid-related fatal overdoses. The increase in opioid use has resulted at least in part from individuals transitioning from prescribed opioids to heroin and fentanyl, which can cause significant respiratory depression that can progress to apnea and death. Heroin and
openaire   +2 more sources

Editorial Commentary: Tobacco or Not—All Nicotine Products Negatively Impact Rotator Cuff Surgery

open access: yesArthroscopy, EarlyView.
Abstract Rotator cuff repair is one of the most common elective orthopaedic surgeries performed; however, failure rates have been reported to range from 10% to 94% depending on the tear characteristics and other patient risk factors. One of the most common risk factors for failure is tobacco use.
Justin J. Ernat
wiley   +1 more source

Status and Rationality of Opioid Use in Lung Cancer Patients: A Single Center Retrospective Study

open access: yesChinese Journal of Lung Cancer, 2020
Background and objective Cancer pain affect the physical activity, psychological state and quality of life seriously, and even shortened the survival time of patients.
Wenjuan SUN   +4 more
doaj   +1 more source

Qualitative identification of fentanyl and other synthetic opioids using ambient ionization high resolution time-of-flight mass spectrometry [PDF]

open access: yes, 2017
The Centers for Disease Control and Prevention deemed the increase in overdose fatalities, due to the use of opioids, an “opioid epidemic” in the United States. Heroin, fentanyl, and other synthetic opioids are commonly abused and are contributing to the
Moore, Amanda Marie
core  

Ethanol reversal of tolerance to the respiratory depressant effects of morphine [PDF]

open access: yes, 2015
Opioids are the most common drugs associated with unintentional drug overdose. Death results from respiratory depression. Prolonged use of opioids results in the development of tolerance but the degree of tolerance is thought to vary between different ...
A Fugelstad   +62 more
core   +5 more sources

Visual Hypersensitivity as a Transdiagnostic Marker of Surgical Pain Response in Arthritis and Chronic Pain Syndromes

open access: yesArthritis &Rheumatology, EarlyView.
Objective Nociplastic pain is pain primarily driven by the central nervous system and, unlike nociceptive pain conditions, is thought to be refractory to peripherally directed therapies. Nociplastic pain is also associated with hypersensitivity to painful and other sensory stimuli (such as visual stimuli). Nonpainful sensory measures have not been well
Noah Waller   +15 more
wiley   +1 more source

The biopsychology of maternal behavior in nonhuman mammals [PDF]

open access: yes, 1990
The term “maternal behavior,” when applied to nonhuman mammals, includes the behaviors exhibited in preparation for the arrival of newborn, in the care and protection of the newly arrived young, and in the weaning of those young, and represents a complex
Kristal, Dr. Mark B.
core  

OGFRL1 Deficiency Causes Chronic Recurrent Multifocal Osteomyelitis Via Pathologic Osteoclastogenesis, With Therapeutic Response to Tumor Necrosis Factor Inhibitor

open access: yesArthritis &Rheumatology, EarlyView.
Objective To verify the pathogenesis of the opioid growth factor receptor like‐1 (OGFRL1) loss‐of‐function variant (c.30del, p. F10Ffs*110) identified in a patient with chronic recurrent multifocal osteomyelitis (CRMO) and to investigate the underlying mechanism.
Wen Xiong   +9 more
wiley   +1 more source

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